Focal cerebral involvement by neurobrucellosis: pathological and MRI findings

Martı́nez-Chamorro, Elena; Muñoz, Alberto; Esparza, J.; Muñoz, Marı́a Jesús; Giangaspro, E.

doi:10.1016/s0720-048x(01)00390-4

Cited by 32 publications

(22 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kronikleşmeye eği-limli olan nörobruselloz genellikle menenjit ve meningoensefalit şeklinde prezante olur (25). Çocuklarda prevelansı %0.8-1 olarak bildirilmiştir (26). Bu çalışmada da 1 (%1.1) olguda Brusellar meningoensefalit tanısı konulmuştur.…”

Section: Discussionunclassified

Bruselloz Tanılı 94 Çocuk Hastanın Retrospektif Olarak Değerlendirilmesi

Kara¹,

Aslan²,

Volkan³

et al. 2016

Kocatepe Tıp Dergisi

View full text Add to dashboard Cite

ÖZAmaç: Bu çalışmada hastanemizde bruselloz tanısı konulan çocuk hastaların sosyodemografik, klinik ve laboratuvar özelliklerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem:Çalışmada Eylül 2009-Aralık 2014 tarihleri arasında, üçüncü basamak sağlık merkezi olan hastanemizde bruselloz tanısı konulan 16 yaş altındaki hastalar retrospektif olarak incelenmiştir. Bulgular: Çalışma süresi boyunca dosya verileri yeterli bulunan 94 çocuk çalışmaya dahil edilmiştir. Hastaların yaş ortalaması 8.85±3.69 yıldır ve %46.8'si erkek, kalan %53.2'si kızdır. Hastaların %75.5'i kırsal kesimde yaşamak-ta, %87.2'inin pastörize edilmemiş süt-peynir tüketimi, %69.1'inin ailesinde hayvancılıkla uğraşma, %30.8'inin ailesinde bruselloz geçirme öyküsü bulunmaktadır. Hastaların doktora ilk başvurusu, semptomları başladıktan ortanca 16 (aralık, 7-45) gün sonra olmuştur. Hastaların en sık başvuru yakınmaları; ateş (%88.2), artralji (%85.1) ve halsizlik (%80.8) iken; en sık fizik inceleme bulguları ateş yüksekliği (%44.6), artrit (%12.7) ve hepatomegali (%8.5) olmuştur. Tanı konulan artritler monoartiküler özellik-te ve en sık diz eklemi tutulumu mevcut idi. Başvuruda hastaların lökosit, C-reaktif protein, eritrosit sedimantasyon hızı ve transaminaz düzeyleri normal sınırlardaydı. Hastaların %13.5'inde en az bir seride sitopeni saptandı. Rose Bengal testi hastaların %91.5'inde, Brusella standart tüp aglütinasyon testi %88.2'sinde, Brusella Coombs aglütinasyon testiyse %94.6'sında pozitifti. Hastaların %7.1'inde kan kültüründe Brucella spp. üremesi oldu. İki hastada hepatit ve 1 hastada meningoensefalit saptandı. Yedi hastada bir yıl içerisinde relaps veya reenfeksiyon gelişirken çalışmada mortalite gözlenmedi. Results: During the study period, 94 children with adequate data were included. The mean age of patients was 8.85±3.69 years and 46.8% was male. Of all, 75.5% were living in rural area, 87.2% had consumption of unpasteurized milk-cheese, 69.1% had animal husbandry, and 30.8% had family brucellosis history. Median admission time after the symptoms was 16 (range, 7-45) days. The most frequent admission symptoms were fever (88.2%), arthralgia (85.1%), and malaise (80.8%), while physical examination findings were fever (44.6%), arthritis (12.7%), and hepatomegaly (8.5%). All of the cases of arthritis were monoarticular and mostly knee was involved. Leukocyte count, C-reactive protein, erythrocyte sedimentation rate, and transaminases were within normal limits. At least one type of cytopenia was observed in 13.5% of patients. Rose Bengal test was positive in 91.5%, Brucellar standard tube agglutination test was positive in 88.2%, Brucellar Coombs agglutination test was positive in 94.6% and Brucella spp. grew in blood culture %7.1 of patients. Two patients had hepatitis and 1 patient had meningoencephalitis. In one year, 7 patients had relapse/ reinfection. No mortality was observed in the study. Conclusion:Brucellosis is a frequent disease in Eastern Anatolian Region and it should always be kept in mind in especially endemic countries ...

show abstract

Section: Discussionunclassified

Bruselloz Tanılı 94 Çocuk Hastanın Retrospektif Olarak Değerlendirilmesi

Kara¹,

Aslan²,

Volkan³

et al. 2016

Kocatepe Tıp Dergisi

View full text Add to dashboard Cite

show abstract

“…Although granulomatous formation results from infl ammation that is relevant to infection, it is a rare manifestation in neurobrucellosis. 23 This disease does not show predilection of size or location of vascular structure. Arterial and/or venous structures may be affected.…”

Section: Neurobrucellosismentioning

confidence: 93%

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Ceran¹,

Türkoğlu²,

Erdem³

et al. 2011

Braz J Infect Dis

View full text Add to dashboard Cite

Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinical manifestations consist of pseudotumor cerebri in one case, white matter lesions and demyelinating syndrome in three cases, intracranial granuloma in one case, transverse myelitis in two cases, sagittal sinus thrombosis in one case, spinal arachnoiditis in one case, intracranial vasculitis in one case, in addition to meningitis in all cases. Eleven patients were male and seven were female. The most prevalent symptoms were headache (83%) and fever (44%). All patients were treated with rifampicin, doxycycline plus trimethoprim-sulfamethoxazole or ceftriaxone. Duration of treatment (varied 3-12 months) was determined on basis of the CSF response. In four patients presented with left mild sequelae including aphasia, hearing loss, hemiparesis. In conclusion, although mortality is rare in neurobrucellosis, its sequelae are signifi cant. In neurobrucellosis various clinical and neuroradiologic signs and symptoms can be confused with other neurologic diseases. In inhabitants or visitors of endemic areas, neurobrucellosis should be kept in mind in cases that have unusual neurological manifestations.

show abstract

“…Basiller hastal›¤›n hematojen yay›l›m› s›ras›nda SSS'ne girer, meninkslere yerleflir ve latent kal›p daha sonra komflu sinir yap›lar›na yay›larak klinik tablo geliflimine yol açabilir (5). Bruselloz'da nörolojik tutulum iki majör grupta incelenebilir (6):…”

Section: Tart›flmaunclassified

“…Nörobrusellozun klinik bulgular›; akut, subakut veya kronik menenjit, meningoensefalit, poliradikülonevrit, myelit veya vaskülit fleklinde görülebilir (5,7,8). Dismyelinizasyon, meningovasküler tutulum, serebral apse ve serebral venöz tromboz oluflumu hastal›¤a ba¤l› geliflen di¤er komplikasyonlard›r ve genellikle meningeal tutulumla birlikte görülürler (9).…”

Section: Tart›flmaunclassified

Brusella Vasküliti: Olgu Sunumu

Gençer¹,

Türkoğlu²,

Yıldırım³

et al. 2011

npa

View full text Add to dashboard Cite

Brucellosis is still common in developing countries. Central nervous system involvement in brucellosis has been reported to be 3-13%. Acute, subacute or chronic meningitis, meningoencephalitis, polyradiculoneuritis, myelitis and vasculitis are the most common features of neurobrucellosis. The aim of this report is to present a case of neurobrucellosis. A 20-year-old male had a stroke (left-sided hemiparesis) due to vasculitic involvement of penetrating cerebral vessels and left abducens palsy related to basal meningeal involvement. Examination of cerebrospinal fluid (CSF) revealed lymphocytic pleocytosis and increased protein as well as raised antibody titers for brucella were detected in the blood and CSF. Neurobrucellosis should be considered in the differential diagnosis of stroke and related disorders because of its endemic nature in our country. (Archives of Neuropsychiatry 2010; 47: 348-50) Resim 1. FLAIR sekansta sa¤ lentiform ve kaudat nükleusta iskemi ile uyumlu hiperintens lezyon Resim 3. Dijital substraksiyon anjiografi incelemesinde sa¤ orta serebral arter M1 segmentinde stenoz Resim 2. T1

show abstract

Focal cerebral involvement by neurobrucellosis: pathological and MRI findings

Cited by 32 publications

References 6 publications

Bruselloz Tanılı 94 Çocuk Hastanın Retrospektif Olarak Değerlendirilmesi

Bruselloz Tanılı 94 Çocuk Hastanın Retrospektif Olarak Değerlendirilmesi

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region

Brusella Vasküliti: Olgu Sunumu

Contact Info

Product

Resources

About