Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration

Montúfar, Edgar B.; Traykova, T.; Gil, Carmen J.; Harr, I.; Almirall, Amisel; Aguirre, Aitor; Engel, Elisabeth; Planell, Josep A.; Ginebra, Maria‐Pau

doi:10.1016/j.actbio.2009.10.018

Cited by 86 publications

(67 citation statements)

References 39 publications

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“…To prepare the macroporous scaffolds, the powder phase consisting of 98wt% α-TCP and 2 wt% of precipitated hydroxyapatite (PHA) was mixed with an aqueous solution of 1 wt% Polysorbate 80 (Sigma-Aldrich, St. Louis, USA) as foaming agent [43]. Both phases were foamed with a domestic food mixer for 30 s at 7000 rpm and then transferred to 6x12 mm PTFE cylindrical moulds where they were left to set in water at 37°C for 10 days.…”

Section: Preparation Of Biomimetic Foamsmentioning

confidence: 99%

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In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Preparation Of Biomimetic Foamsmentioning

confidence: 99%

“…We took advantage of the possibility offered by the fabrication of hydroxyapatite scaffolds using biomimetic routes, i.e., by low temperature dissolutionprecipitation reactions, to systematically introduce controlled levels of porosity at the nano, micro, and macroscale, as well as to modify the specific surface area [41][42][43].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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“…One phase of the CaP ceramic is hydroxyapatite (HAp). Having a chemical formula (Ca 10 (PO 4 ) 6 (OH) 2 ), stoichiometric HAp has a structure very similar to that of natural bone [24,26,34,[43][44][45]. For this reason, synthetic CaP materials including HAp are FDA-approved and were among the most investigated materials for scaffold composition for over three decades [46][47][48][49][50][51].…”

Section: Bioceramics For Sbd Repairmentioning

confidence: 99%

“…Figure 1 illustrates a critical size defect in which the orthopedic surgeon placed bone cement and all the necessary hardware to hold it in place. The implantation of these tissue-engineered biological constructs, also known as scaffolds, has been a major advancement in the field of orthopedics [22,[29][30][31][32][33][34][35][36]. Before understanding what the ideal bone scaffold requirements are, it is first necessary to determine the material and biological properties of these constructs.…”

Section: Bone Tissue-engineered Scaffolds For the Treatment Ofmentioning

confidence: 99%

Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

Pilia¹,

Guda²,

Appleford³

2013

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The need for a suitable tissue-engineered scaffold that can be used to heal load-bearing segmental bone defects (SBDs) is both immediate and increasing. During the past 30 years, various ceramic and polymer scaffolds have been investigated for this application. More recently, while composite scaffolds built using a combination of ceramics and polymeric materials are being investigated in a greater number, very few products have progressed from laboratory benchtop studies to preclinical testing in animals. This review is based on an exhaustive literature search of various composite scaffolds designed to serve as bone regenerative therapies. We analyzed the benefits and drawbacks of different composite scaffold manufacturing techniques, the properties of commonly used ceramics and polymers, and the properties of currently investigated synthetic composite grafts. To follow, a comprehensive review of in vivo models used to test composite scaffolds in SBDs is detailed to serve as a guide to design appropriate translational studies and to identify the challenges that need to be overcome in scaffold design for successful translation. This includes selecting the animal type, determining the anatomical location within the animals, choosing the correct study duration, and finally, an overview of scaffold performance assessment.

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“…These procedures are usually the same used to obtain cellular ceramics. Among these techniques replica methods 11 , porogenic agents sacrifice 12 , rapid prototyping 13 and direct foaming 14 are predominant. Among the advantages of the latter are the simplicity of the process and the induction of macroporosity before setting, which allows injectability of the foamed paste.…”

Section: Introductionmentioning

confidence: 99%

Preparation of an Injectable Macroporous α-TCP Cement

Niño

Santos

2016

Mat. Res.

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One of the most important characteristics of calcium phosphate cements is their resorbability when implanted in the body. However, the in vivo resorption rate is slow due to the lack of intrinsic open porosity. In this study, macroporous structures were obtained by mixing alpha-tricalcium phosphate (α-TCP) cement with a foamed liquid phase containing different concentrations of sodium hydrogen phosphate and non-ionic (Lutensol) or anionic (Sodium Lauryl Sulfate) surfactant. The cement paste was prepared by hand mixing in a system of two syringes connected by a polyvinyl chloride (PVC) valve, an environmentally friendly method. Solutions with Lutensol (L110) showed greater foamability than solutions with Sodium Lauryl Sulfate (SLS). Scanning Electron Microscopy characterization helped verify that the prepared samples showed a macroporous interconnected structure, and X-ray diffraction analysis evidenced the transformation of α-TCP into calcium deficient hydroxyapatite (CDHA). This study suggests that the calcium phosphate cement samples foamed with Lutensol may be further evaluated as suitable materials for bone filling.

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Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration

Cited by 86 publications

References 39 publications

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

Preparation of an Injectable Macroporous α-TCP Cement

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