Preparation of an Injectable Macroporous α-TCP Cement

Niño, Andrés Felipe Vásquez; Santos, Luís Alberto Loureiro dos

doi:10.1590/1980-5373-mr-2016-0229

Cited by 10 publications

(3 citation statements)

References 20 publications

(17 reference statements)

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“…XRD of CPC preincubation shows the main diffraction peaks of α-TCP. 21 XRD of the different CPC-porogen formulations after 7 days of incubation shows similar patterns for all formulations, with the main diffraction peaks of hydroxyapatite (HA), 22 indicating the transition of α-TCP to HA after 7 days of incubation for all formulations.…”

Section: Characterization Of Cpc Formulations Sem Images (Supporting mentioning

confidence: 95%

Multimodal porogen platforms for calcium phosphate cement degradation

Lodoso‐Torrecilla

Grosfeld

Marra

et al. 2019

J Biomedical Materials Res

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Calcium phosphate cements (CPCs) represent excellent bone substitute materials due to their biocompatibility and injectability. However, their poor degradability and lack of macroporosity limits bone regeneration. The addition of poly( d,l ‐lactic‐co‐glycolic acid) (PLGA) particles improves macroporosity and therefore late stage material degradation. CPC degradation and hence, bone formation at an early stage remains challenging, due to the delayed onset of PLGA degradation (i.e., after 2–3 weeks). Consequently, we here explored multimodal porogen platforms based on sucrose porogens (for early pore formation) and PLGA porogens (for late pore formation) to enhance CPC degradation and analyzed mechanical properties, dynamic in vitro degradation and in vivo performance in a rat femoral bone defect model. Porogen addition to CPC showed to decrease compressive strength of all CPC formulations; transition of the crystal phase upon in vitro incubation increased compressive strength. Although dynamic in vitro degradation showed rapid sucrose dissolution within 1 week, no additional effects on CPC degradation or bone formation were observed upon in vivo implantation. © 2019 The Authors. journal Of Biomedical Materials Research Part A Published By Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1713–1722, 2019.

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Section: Characterization Of Cpc Formulations Sem Images (Supporting mentioning

confidence: 95%

Multimodal porogen platforms for calcium phosphate cement degradation

Lodoso‐Torrecilla

Grosfeld

Marra

et al. 2019

J Biomedical Materials Res

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“…Several approaches have been described in the literature to obtain macroporosities in phosphate-based cements. For CPCs, macropores were obtained by foaming [18][19][20], using porogens such as mannitol [21,22], frozen sodium phosphate solutions [23], tri-calcium phosphate granules [24] and sucrose fatty acid esters [14]. Despite these efforts, none of the commercially available CPCs offers the possibility of macropore formation [17], suggesting the need to develop more effective strategies to prepare these systems in a more feasible way.…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

Alendronate-loaded gelatin microparticles as templating agents for macroporous magnesium phosphate-based bone cements

et al. 2022

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Magnesium phosphate-based cements (MPCs) have recently attracted great attention as materials for bone repair. However, the lack of macroporosity, fundamental for cells permeation and bone ingrowth, is one of the main limitations hampering MPCs full exploitation. In this work gelatin microparticles are exploited as templating agents for the creation of macroporosities in MPCs. In addition, gelatin particles were loaded with a well-recognized drug for the treatment of osteoporosis, alendronate, to locally release the therapeutic agent. Gelatin microparticles of different size were prepared with a simple water-in-oil emulsion method and included in MPCs at various concentrations. The properties of both the MPCs and the final material were characterized by assessing the composite in terms of injectability, setting time, infrared spectroscopy, scanning electron microscopy and confocal Raman microscopy. The MPC-gelatin composites were then incubated in water at physiological temperature, to promote the dissolution of the gelatin, obtain a macroporous cement, and release gelatin and alendronate. The obtained results show that gelatin microparticles have a twofold action as they allow for the formation of MPC with an interconnected and hundreds of µm-sized porosity and the local release of alendronate, resulting in a material with ideal features for bone repair. Graphical abstract

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“…Since many years, the use of functional materials has been intensively investigated for biomaterial applications. The use of osteoinductive materials 13 and functionalization techniques, such as surface coating using bioactive materials 14 or chemical surface modifications 15 have been developed.…”

Section: Introductionmentioning

confidence: 99%

Dimensional evaluation of patient-specific 3D printing using calcium phosphate cement for craniofacial bone reconstruction

2016

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The 3D printing process is highlighted nowadays as a possibility to generate individual parts with complex geometries. Moreover, the development of 3D printing hardware, software and parameters permits the manufacture of parts that can be not only used as prototypes, but are also made from materials that are suitable for implantation. In this way, this study investigates the process involved in the production of patient-specific craniofacial implants using calcium phosphate cement, and its dimensional accuracy. The implants were previously generated in a computer-aided design environment based on the patient's tomographic data. The fabrication of the implants was carried out in a commercial 3D powder printing system using alfa-tricalcium phosphate powder and an aqueous solution of NaHPO as a binder. The fit of the 3D printed implants was measured by three-dimensional laser scanning and by checking the right adjustment to the patient's anatomical biomodel. The printed parts presented a good degree of fitting and accuracy.

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Preparation of an Injectable Macroporous α-TCP Cement

Cited by 10 publications

References 20 publications

Multimodal porogen platforms for calcium phosphate cement degradation

Multimodal porogen platforms for calcium phosphate cement degradation

Alendronate-loaded gelatin microparticles as templating agents for macroporous magnesium phosphate-based bone cements

Dimensional evaluation of patient-specific 3D printing using calcium phosphate cement for craniofacial bone reconstruction

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