“…Meanwhile, fluvoxamine decreased the total peripheral resistance, leading to the hypotensive action. Although in vitro vasodilator effect of fluvoxamine has not been reported, the hypotensive action has been observed in patients (de Wilde et al, 1983;de Wilde and Doogon, 1982;Granfors et al, 2004;Guelfi et al, 1983;Rodriguez de la Torre et al, 2001), which was not detected in dogs, cats (Roos, 1983) or healthy human volunteers (Robinson and Doogan, 1982). Importantly, fluvoxamine increased the LVEDP in a dose-related manner; however, the maximum value was 13 ± 1 mmHg at 10 min after the high dose, which still remained within a physiological range.…”