The three-dimensional (3D) magnetohydrodynamic (MHD) equilibrium solver HINT is improved as a new HINT code, 'HINT2' having various useful features by introducing modern computing techniques. By using the algorithm inherent to HINT2, the treatment of the peripheral plasma corresponding to the experimental results is addressed in the Large Helical Device (LHD).

OVERVIEW OF THE LARGE HELICAL DEVICE PROJECT. The Large Helical Device (LHD) has successfully started running plasma confinement experiments after a long construction period of eight years. During the construction and machine commissioning phases, a variety of milestones were attained in fusion engineering which successfully led to the first operation, and the first plasma was ignited on 31 March 1998. Two experimental campaigns are planned in 1998. In the first campaign, the magnetic flux mapping clearly demonstrated a nested structure of magnetic surfaces. The first plasma experiments were conducted with second harmonic 84 and 82.6 GHz ECH at a heating power input of 0.35 MW. The magnetic field was set at 1.5 T in these campaigns so as to accumulate operational experience with the superconducting coils. In the second campaign, auxiliary heating with NBI at 3 MW has been carried out. Averaged electron densities of up to 6 × 10 19 m-3 , central temperatures ranging from 1.4 IAEA-F1-CN-69/OV1/4 2 to 1.5 keV and stored energies of up to 0.22 MJ have been attained despite the fact that the impurity level has not yet been minimized. The obtained scarling of energy confinement time has been found to be consistent with the ISS95 scaling law with some enhancement.

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Laboratory data and clinical features demonstrated that the patients have a mild form of ECHS1 deficiency harbouring defective valine catabolic and β-oxidation pathways. N-Acetyl-S-(2-carboxypropyl) cysteine level was markedly high in the urine of the patients, and therefore, N-acetyl-S-(2-carboxypropyl)cysteine was regarded as a candidate metabolite for the diagnosis of ECHS1 deficiency. This metabolite is not part of current routine metabolic screening protocols, and its inclusion, therefore, holds immense potential in accurate diagnosis.

Optimization studies have been done for the helical axis heliotron configuration. One purpose is to find a configuration suitable for experimental studies of the basic properties of a helical axis heliotron. In the present study, the role of the bumpy field component (toroidal mirror ratio) in MHD stability and neoclassical confinement for this type of configuration is examined. The physical mechanism of the improvement of the neoclassical transport through control of the bumpy field component is clarified. The physics design and current status of the new helical axis heliotron device, Heliotron J, are also described.

A series of lanostane-type triterpene acids, including eleven lucidenic acids (3, 4, 9, 10, 13-19) and six ganoderic acids (20-22, 24, 26, 27), as well as six sterols (28-33), all isolated from the fruiting bodies of the fungus Ganoderma lucidum, were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, a known primary screening test for anti-tumor promoters. All of the compounds tested, except for ganolactone (27) and three sterols (29-31), showed potent inhibitory effects on EBV-EA induction, with IC(50) values of 235-370 mol ratio/32 pmol TPA. In addition, nine lucidenic acids (1, 2, 5-8, 11, 12, 18) and four ganoderic acids (20, 23-25) were found to inhibit TPA-induced inflammation (1 microg/ear) in mice, with ID(50) values of 0.07-0.39 mg per ear. Further, 20-hydroxylucidenic acid N (18) exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter.

The structures of six new lanostane-type triterpene acids isolated from the epidermis of the sclerotia of Poria cocos were established to be 15alpha-hydroxydehydrotumulosic acid (5), 16alpha,25-dihydroxydehydroeburicoic acid (9), 5alpha,8alpha-peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid H (11), 16-deoxyporicoic acid B (12), and poricoic acid CM (16) on the basis of spectroscopic methods. On evaluation of these six and 11 other known triterpene acids isolated from the sclerotium, 1-4, 6-8, 13-15, and 17, against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds except for 1, 3, 4, and 8 exhibited inhibitory effects with IC50 values of 195-340 mol ratio/32 pmol TPA. Compound 12 and poricoic acid C (13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

The dynamics of the magnetic island structure in the plasma are investigated in plasmas with a wide range of beta and collisionality. The perturbed magnetic field is diagnosed by a toroidal array of flux loops installed in the vacuum vessel on the Large Helical Device (LHD). It is found that the magnetic island grows with beta at relatively low beta values. In contrast, when the beta exceeds a critical value, the sign of the perturbed magnetic field suddenly reverses and its strength saturates to the magnetic field perturbation required to cancel the external perturbation. This suggests spontaneous healing of the magnetic island.