Fluoroquinolones as sensitizers of lanthanide fluorescence: application to the liquid chromatographic determination of ciprofloxacin using terbium

Rieutord, André; Vázquez, Leonardo; Soursac, M.; Prognon, Patrice; Blais, J.; Bourget, P.; Mahuzier, G.

doi:10.1016/0003-2670(94)80058-8

Cited by 84 publications

(66 citation statements)

References 35 publications

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“…The literature informs that C. sylvestris extract has two main points of absorption, the 235nm related the casearins and the 269nm related to phenols [5]. However the 269nm wavelength is also related to ciprofloxacin that has its maximum of absorption at 270nm [10]. Because of this, in this study, to avoid errors and over estimation of data, the quantifier methods were made by using the 235nm as the one related to the extract casearins and the 320nm wavelength as the one related to the ciprofloxacin.…”

Section: Resultsmentioning

confidence: 99%

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Bolognesi¹,

Borges²,

Cinman³

et al. 2015

ACSJ

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In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis, the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and Bolognesi et al.; ACSj, 5(1): 17-25, 2015; Article no. ACSj.2015.003 18 wound healing effects due to its casearins and the antibiotic ciprofloxacin which is considered as one of the main drugs used for open wounds in the skin. The study occurred at State São Paulo University in Assis (UNESP-FCL), Brazil. The substances were mixed and a film was made by casting at ambient temperature creating circular films with 5cm of diameter. After that the film was placed in 1 liter of water to start the release study. The release behavior was analyzed by UV-VIS spectrophotometry being the casearins related to the wavelength of 235nm and the ciprofloxacin of 320nm. The film supported the release of compounds, releasing 93.73% of the extract and 56.53% of the drug, along 29 hours. In addition, the incorporation was proven by Scanning Electron Microscopy (SEM), which showed the morphology of pure and incorporated films and also by Fourier Transform Infrared Spectroscopy (FTIR) which has shown that no chemical change occurred during the process. Thereby, according to results, the material has a possible approach to biomedical application. Original Research Article

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Section: Resultsmentioning

confidence: 99%

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Bolognesi¹,

Borges²,

Cinman³

et al. 2015

ACSJ

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“…Both UFX and Tb(III)-UFX have two main excitation peaks: one locates at 273 nm, the other locates at about 340 nm. In the earlier reports about Tb(III) sensitized fluorescence, in order to avoid direct excitation of Tb(III), 23 the disturbance of the scattered excitation light and the inner filtering effect, 24 273 nm was not used as the incident wavelength, although it would bring higher sensitivity. As shown in Fig.…”

Section: Spectra Characteristicsmentioning

confidence: 99%

“…Although FQs have the same nucleus, structural variations, especially the N1 substituents, can affect their abilities to chelate with Tb(III) ion and the energy transfer efficiencies. 23 The introduction of substituents with different donor properties results in the electron density redistribution over pyridine ring and affects the charge of the oxygen atoms. 25 Take norfloxacin (NFLX), ofloxacin (OFLX) (Scheme 2) and UFX as examples.…”

Section: The Luminescence Property Of Tb(iii)-fq By Comparing Ufx Witmentioning

confidence: 99%

“…For ofloxacin, the benzoxazine group appears as an efficient electron-attracting system acting as a quencher of the fluorescence process. 23 For NFLX and UFX, the ethyl group and the thioceto group on the N1 position act as 1375 ANALYTICAL SCIENCES DECEMBER 2007, VOL. 23 Recovery ± RSD, % (n = 5)…”

Section: The Luminescence Property Of Tb(iii)-fq By Comparing Ufx Witmentioning

confidence: 99%

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Determination of Ulifloxacin by Terbium-sensitized Fluorescence with Second-order Scattering and Its Applications

et al. 2007

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IntroductionAs broad-spectrum antibiotics, fluoroquinolones (FQs) have gained increasing use and have become popular in clinical application thanks to their high bacteriologic and clinical cure rates and good pharmacokinetic profile. 1 Prulifloxacin (PUFX, Scheme 1), 6-fluoro-1-methyl-7-(4-[5-methyl-2-oxo-1,3-dioxolen-4-yl]-methyl-1-piprazinyl)-4-oxo-4H-(1,3)thiaceto(3,2-α)quinolone-3-carboxylic acid, is a new oral fluoroquinolone antibiotics. It is active against both gram-positive and gram-negative bacteria and several anaerobic and atypical bacteria associated with chronic bronchitis and urinary infections. 2After PUFX is administrated, it is immediately and quantitatively transformed to the active metabolite ulifloxacin (UFX, Scheme 1) which actually has antibacterial activity. Prulifloxacin is not detectable in the systemic circulation. 3 That is to say, PUFX is the prodrug of UFX. The oxodioxolenylmethyl group in the 7-piperazine ring helps PUFX to have an advantage over UFX on oral absorption.3 Thus, the main form existing in biological fluids, such as serum and urine, is UFX. It is thus necessary to develop rapid, selective and sensitive analytical methods for the determination and pharmacokinetic study of UFX.Analytical literature about the determination of UFX is seldom seen. There are a few papers that describe HPLC methods. 4-6The HPLC methods allow the separation and generally require expensive equipment and complicated procedures. The main advantages of fluorometry are simplicity and rapidity. Luminescence sensitization of lanthanide ions (especially Tb(III) and Eu(III)) allows their application as the luminescence probes. Lanthanide-sensitized luminescence provides a selective and sensitive approach that shows a large stokes shift, narrow emission bands and a long luminescence lifetime. The carboxylate and the keto oxygen atoms of FQs provide the chelated sites for Tb(III) or Eu(III) ion to form Ln(III)-FQ complex. When Tb(III)-FQ complex is excited, it gives rise to the characteristic luminescence of Tb(III) ion with maximum emission at 545 nm via intramolecular energy transfer. This terbium-sensitized method has been used in the determination of FQs. 7-11In recent years, the light scattering technique has been increasingly applied to analytical chemistry, the most common method used is resonance light scattering (RLS). In studying RLS, the strong scattering of light at double the wavelength of the incident light (λem = 2λex) is found, which is named as "second-order scattering (SOS)". 12 As it may interfere with fluorometric measurements, SOS is always minimized and if possible eliminated as a harmful phenomenon in the fluorometric determinations. 13 Since Liu et al. first studied SOS as an analytical technique and applied it in the determination of metal ions in 1995, 14,15 however, it has been used as a new analytical technique with sensitive application prospects. 16,17 We have reported some flow-injection lanthanide-sensitized chemiluminescence (CL) [18][19][20] and electrochemiluminescence ...

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“…In order to avoid direct excitation of Tb(III), 21 the disturbance of the scattered excitation light and the inner filtering effect, 22 we selected 330 nm (lower excitation band) rather than 251 nm as the excitation wavelength (λex). The most intense band located at 545 nm is the 5 D4→ 7 F5 transition, so 545 nm was selected for the emission wavelength (λem).…”

Section: +mentioning

confidence: 99%

Terbium-Sensitized Fluorescence Method for the Determination of Pazufloxacin Mesilate and Its Application

Chen

Zhao

et al. 2004

ANAL. SCI.

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A simple, rapid and highly sensitive fluorometric method for the determination of pazufloxacin mesilate (PZFX) is described. It is based on the formation of the complex [Tb(PZFX)2] 3+ , which shows the intensive characteristic bands of Tb 3+ . Optimum conditions for the determination were investigated. Under the optimum experimental condition, the fluorescence intensity responds linearly to the PZFX concentration in the range of 2.0 × 10 -8 -5.0 × 10 -6 mol/l with a detection limit of 6.2 × 10 -9 mol/l. The method has been successfully applied to the determination of PZFX in urine and serum samples.

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Fluoroquinolones as sensitizers of lanthanide fluorescence: application to the liquid chromatographic determination of ciprofloxacin using terbium

Cited by 84 publications

References 35 publications

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Determination of Ulifloxacin by Terbium-sensitized Fluorescence with Second-order Scattering and Its Applications

Terbium-Sensitized Fluorescence Method for the Determination of Pazufloxacin Mesilate and Its Application

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