Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Abstract

In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis, the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and Bolognesi et al.; ACSj, 5(1): 17-25, 2015; Article no. ACSj.2015.003 18 wound healing effects due to its casearins and the antibiotic ciprofloxacin which is considered as one of the main drugs used for open wounds in the skin. The study occurred at State São Paulo University in Assis (UNESP-FCL), Brazil. The substances were mixed and a film was made by casting at ambient temperature creating circular films with 5cm of diameter. After that the film was placed in 1 liter of water to start the release study. The release behavior was analyzed by UV-VIS spectrophotometry being the casearins related to the wavelength of 235nm and the ciprofloxacin of 320nm. The film supported the release of compounds, releasing 93.73% of the extract and 56.53% of the drug, along 29 hours. In addition, the incorporation was proven by Scanning Electron Microscopy (SEM), which showed the morphology of pure and incorporated films and also by Fourier Transform Infrared Spectroscopy (FTIR) which has shown that no chemical change occurred during the process. Thereby, according to results, the material has a possible approach to biomedical application. Original Research Article

Study of thermal and mechanical properties of a biocomposite based on natural rubber and 45S5 Bioglass® particles

“…The mass loss in the temperature range 300-450°C (the most intense peak shown in Fig. 3b) is due to the structural decomposition of NR chains and corresponds to approximately 88, 74, 56, and 41% for the NR, 90/10, 70/30, and 50/50 samples, respectively [38,39]. For the NR, the maximum rate of mass loss occurs at 365°C, as exhibited by the most intense peak in Fig.…”

Latex and natural rubber: recent advances for biomedical applications

“…Extract of Casearia sylvestris Sw. and ciprofloxacin was incorporated into NR films preserving the properties of the substances since no chemical interaction between materials was observed [40] . The release rate of the extract was higher (~94%) than that of ciprofloxacin (~54%), both substances being adhered to the surface of porous NR films.…”

Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

“…Latex is extracted from the rubber tree Hevea brasiliensis , and it is both a healing substance and defense mechanism for this organism [ 17 ]. Numerous research which used natural latex as an implant on different tissues have presented satisfactory results, which motivate the development of new works in the area [ 13 , 17 – 20 ]. Regarding this scope, personalized insoles made with natural latex have been used as an important tool for the reduction of plantar pressure in the treatment of patients with a diabetic foot [ 12 , 17 ].…”

“…The research of Duff A. C. indicates that one in four of young diabetics (age 11-24) has increased plantar pressure and/or plantar blister (lump, tissue thickening—lat. plantar callus) [ 13 , 20 , 21 ]. The impacted areas are high-risk areas for development of some variety of foot conditions in adulthood.…”