Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

Abstract

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Thus, latex biomembrane (LBM), a biocompatible material, derived from the latex of the rubber tree (Hevea brasiliensis) appears to create tendencies as an angiogenic-inducing tissue healing agent and as biomaterial, resulting from its structural qualities and its low cost when compared to conventional treatments. Therefore, this work aims at summarizing the results, experiments, and scientific findings that certify or recommend the use of LBM as a new technique to be applied effectively in the treatment of wounds. An integrative review was held in the BIREME, LILACS, Burns, MEDLINE, PubMed, and SciELO databases, from 2000 to 2016, using the following descriptors: “healing,” “diabetes mellitus,” “wounds,” and “latex membrane.” As a result, 600 experiments (out of 612) presented satisfactory results; however, 33% of the cases received explicit recommendations, 11% required more studies on the subjects, and 1% was denied. On the other hand, half of the studies did not expressly endorse its use, despite presenting satisfactory results. The LBM was characterized as a good therapeutic alternative in cases of wounds, including chronic diseases, such as diabetes mellitus and PU, due to its relevant potential for wound healing stimulation, acceleration of cell tissue mending and revascularization, or the reestablishment of angiogenic functions (creation of new blood vessels). The LBM was also confirmed to be safe as a biocompatible material whose structural qualities (elasticity, adaptability, impermeability, and possibility of suture), devoid of toxicity, allowed interaction between tissues and presented no hypersensitivity inducer and no antimicrobial effect.

Multicolored Nanocolloidal Hydrogel Inks

“…From the practical standpoint, aqueous latex NP dispersions can be used for the preparation of films and coatings from both hydrophilic and hydrophobic polymers, [20][21][22][23] with applications as paints, [24] films for biometrics and optical data storage, [25][26][27][28] self-healing coatings, [29] and membranes. [30] Importantly, in such systems, high molecular weight polymers can be used without increase in dispersion viscosity. [31] Despite the fact that the thixotropy of latex dispersions has been known for a long time and even used in inkjet printing, [32] nanocolloidal hydrogel inks formed solely from attractive percolating latex NPs have not been reported for 3D printing of functional materials.…”

Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion, and immunomodulation

“…Müll.Arg.) (Rosa et al, 2019), non‐starch soluble polysaccharides are hydrophilic and do not mix with oils, but dissolve readily in water. The common species that yield these soluble polysaccharides also have a rich history of use in anti‐ageing, dermal wound healing, and gastric/diabetic health, such as A. vera (Surjushe, Vasani, & Saple, 2008; Van Wyk, 2011), Bulbine frutescens (Van Wyk, 2011), Amorphophallus konjac (Chua, Baldwin, Hocking, & Chan, 2010), and Trigonella foenum‐graecum (Bahmani, Shizad, Mirhosseini, Mesripour, & Rafieian‐Kopaei, 2016).…”

Concentration‐dependent effects of latex F1‐protein fraction incorporated into deproteinized bovine bone and biphasic calcium phosphate on the repair of critical‐size bone defects

“…A biomembrane prepared from the natural rubber tree, Hevea brasiliensis showed good biocompatibility (Mrue et al, 2004), as well as an ability to stimulate wound healing through mechanism involving a marked increase in vascularization (Andrade et al, 2011; Mendonça & Maurício, 2010). Subsequently, many clinical evidences of stimulation of wound healing, acceleration of revascularization, and reestablishment of angiogenic functions of chronic wounds in diabetes mellitus and pressure ulcers treated with biomembrane of latex were reported (Rosa et al, 2019): According to Frade et al (Frade, Assis, Coutinho‐Netto, Andrade, & Foss, 2012; Frade, Valverde, de Assis, Coutinho‐Netto, & Foss, 2001), the presence of growth factors in latex allowed improved local vascularization through its capacity to induce angiogenesis and accelerate the repair of diabetic and phlebopathic ulcers, consequently leading to re‐epithelialization.…”