Fluoroquinolone antibiotic determination in bovine milk using capillary liquid chromatography with diode array and mass spectrometry detection

Ruiz-Viceo, J.A.; Rosales-Conrado, Noelia; Guillén-Casla, Vanesa; Pérez-Arribas, L.V.; León-González, María Eugenia; Polo-Díez, L.M.

doi:10.1016/j.jfca.2012.08.003

Cited by 22 publications

(3 citation statements)

References 17 publications

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“…According to previous papers, a variety of analytical methods for the racemic determination of flumequine in animal productions (including milk, honey, egg, fish, shrimp, chicken, pork, and beef) have been published using capillary electrophoresis (CE), 6,7 CE tandem mass spectrometry (CE-MS/MS), 8,9 liquid chromatographyultraviolet detection (LC-UV), [10][11][12][13][14][15] and liquid chromatography tandem mass spectrometry (LC-MS/MS). [16][17][18][19][20][21] LC-UV and LC-MS have been widely utilized for quantification analysis of flumequine.…”

Section: Abbreviationsmentioning

confidence: 99%

Enantioseparation and determination of flumequine enantiomers in multiple food matrices with chiral liquid chromatography coupled with tandem mass spectrometry

Liu

Xue

et al. 2019

Chirality

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The present work firstly described the enantioseparation and determination of flumequine enantiomers in milk, yogurt, chicken, beef, egg, and honey samples by chiral liquid chromatography‐tandem mass spectrometry. The enantioseparation was performed under reversed‐phase conditions on a Chiralpak IC column at 20°C. The effects of chiral stationary phase, mobile phase components, and column temperature on the separation of flumequine enantiomers have been studied in detail. Target compounds were extracted from six different matrices with individual extraction procedure followed by cleanup using Cleanert C18 solid phase extraction cartridge. Good linearity (R2>0.9913) was obtained over the concentration range of 0.125 to 12.5 ng g‐1 for each enantiomer in matrix‐matched standard calibration curves. The limits of detection and limits of quantification of two flumequine enantiomers were 0.015‐0.024 and 0.045‐0.063 ng g‐1, respectively. The average recoveries of the targeted compounds varied from 82.3 to 110.5%, with relative standard deviation less than 11.7%. The method was successfully applied to the determination of flumequine enantiomers in multiple food matrices, providing a reliable method for evaluating the potential risk in animal productions.

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Section: Abbreviationsmentioning

confidence: 99%

Enantioseparation and determination of flumequine enantiomers in multiple food matrices with chiral liquid chromatography coupled with tandem mass spectrometry

Liu

Xue

et al. 2019

Chirality

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“…The health risks associated with antibiotic accumulation have raised concerns worldwide. Many governments, such as those of the United States, the European Union, and China, have successively established strict regulations and measures to control antibiotic residues in fish products [9][10][11]. However, there are challenges and issues associated with monitoring and regulating antibiotics in fish products.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Health Risk Assessment of Sulfonamide Antibiotics in Different Freshwater Fish in Northeast China

Shen,

Yu,

et al. 2023

Toxics

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This study aimed to investigate the levels of 12 sulfonamide antibiotics in freshwater fish species obtained from three cities in northeastern China (Harbin, Changchun, and Shenyang). The analysis was conducted using HPLC–MS/MS to accurately quantify the antibiotic concentrations in the fish samples. The results showed that the average levels of sulfonamide antibiotics in fish samples from Harbin, Changchun, and Shenyang were 1.83 ng/g ww, 0.98 ng/g ww, and 1.60 ng/g ww, respectively. Sulfamethoxazole displayed the highest levels and detection rates in all three cities, whereas sulphapyridine exhibited the lowest concentrations in all the fish samples. The levels of sulfonamide antibiotic residues in the different fish species varied widely among the cities, and the highest level of antibiotic residues was found in the muscle of carnivorous fish. The results from a health risk evaluation on the consumption of these fish indicated that the risk from long-term antibiotic exposure to local residents from the intake of the sampled fish was small and not sufficient to pose a significant health risk to consumers.

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“…Fluoroquinolones are a class of synthetic antibiotics that are primarily used to treat and prevent bacterial infections [ 3 , 10 , 11 ]. Given the safety concerns posed by these antibiotics, many of them are prohibited as veterinary drugs for livestock production by several countries including USA, Australia, China, EU member countries, UK, and Canada [ 12 , 13 , 14 ]. However, to safeguard the public health and minimize the potential exposure to antibiotic residues from food products, maximum residue limits (MRLs) have been established by the USA Food and Drug Administration [ 15 ] and European Union (Commission Decision 37/2010/CE [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Detection and quantification of multiclass antibiotic residues in poultry products using solid-phase extraction and high-performance liquid chromatography with diode array detection

Oyedeji

Msagati

Williams

et al. 2021

Heliyon

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This article describes the initial study on the simultaneous determination of multiclass antibiotic residues in imported and local frozen poultry specimens, including turkey gizzard and muscle tissues, and chicken muscle tissues, commonly consumed in Ogun State, Nigeria. Minced tissues were treated with phosphate buffer adjusted to pH 7 that was cleaned using C18 SPE-column (Supelclean™) cartridge. For the determination of six antibiotic residues including fluoroquinolones, sulfonamides, and macrolides, a solid-phase extraction method was used, followed by extract analysis using high-performance liquid chromatography–diode array detection (HPLC–DAD). The coefficient of determination (R 2 ) for the external standards for all the analytes ranged between 0.963 and 0.999. The limit of detection (LOD) and quantification (LOQ) ranged between 5.37 – 55.4 μg/kg, and 17.9–185 μg/kg, respectively. Enrofloxacin, sulfadimethoxine, sulfamerazine, and tylosin showed high concentration levels in the frozen poultry beyond acceptable maximum residue limits (MRLs). The six drugs considered in this study were present at higher concentrations in domestic chicken tissues than the permissible level. This suggests that farmers do not observe the cessation period before poultry birds previously treated with antibiotics are sold to consumers thus exposing them to potentially hazardous antibiotic residues.

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Fluoroquinolone antibiotic determination in bovine milk using capillary liquid chromatography with diode array and mass spectrometry detection

Cited by 22 publications

References 17 publications

Enantioseparation and determination of flumequine enantiomers in multiple food matrices with chiral liquid chromatography coupled with tandem mass spectrometry

Enantioseparation and determination of flumequine enantiomers in multiple food matrices with chiral liquid chromatography coupled with tandem mass spectrometry

Occurrence and Health Risk Assessment of Sulfonamide Antibiotics in Different Freshwater Fish in Northeast China

Detection and quantification of multiclass antibiotic residues in poultry products using solid-phase extraction and high-performance liquid chromatography with diode array detection

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