Fluorometric Histamine Determination in Canine Plasma under Normal Conditions, following Application of Exogenous Histamine, and during Histamine Release by Haemaccel

Lorenz, W.; Barth, H.; Thermann, M.; Schmal, A.; Dormann, P.; Niemeyer, Ilka

doi:10.1515/bchm2.1974.355.2.1097

Cited by 50 publications

(75 citation statements)

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“…None of these drugs caused significant histamine release which might have lowered gastric histamine concentration . Only the substances described by Lorenz et al (1972aLorenz et al ( , 1974a were used, as reagents in order to exclude impurities interfering with the assay. Twice-distilled water was prepared in a quartz still (K6ttermann Ltd.).…”

Section: Gastric Ulcer Patientsmentioning

confidence: 99%

“…After elution of histamine from the columns, condensation with 0.1% o-phthaldialdehyde was carried out to lower the reagent blanks and to increase the sensitivity of the assay ). Thanks to a new photomultiplier used (Lorenz et al, 1974a), very small slide widths could be applied on the Zeiss fluorometer. Histamine was expressed as pg histamine dihydrochloride/g.…”

Section: Fluorometric Assay Of Histamine In Biopsy Specimensmentioning

confidence: 99%

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Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

et al. 1976

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Section: Gastric Ulcer Patientsmentioning

confidence: 99%

Section: Fluorometric Assay Of Histamine In Biopsy Specimensmentioning

confidence: 99%

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

et al. 1976

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“…6 in Lorenz et at. [22]) which in human subjects caused life-threatening anaphylactoid reactions, too [12]. The premedication by H1 +Ha-receptor antagonists did not change significantly the extent of histamine release elicited by "classical" polygeline (Table 11).…”

Section: Trial 2: Systemic Anaphytactoid Reactionmentioning

confidence: 99%

Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: Synopsis of three randomized controlled trials

Schöning

Lorenz

Doenicke³

1982

Klin Wochenschr

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Summary.To demonstrate the efficacy of a premedication with H a--}-H2-receptor antagonists against histamine-release responses in anaesthesia and surgery 3 randomized controlled trials were conducted in patients, volunteers and experimental animals (dogs). Cutaneous anaphylactoid reactions following infusion of polygeline (Haemaccel ®) in orthopedic patients were successfully abolished by premedication with 0.1 mg/kg dimethpyrindene (Fenistil) and 5 mg/kg cimetidine (Tagamet). Chlorpheniramine (Piriton) was also useful, but dimethpyrindene was more effective in the doses recommended and used. Side-effects of the premedication were not observed when the 2 drugs were slowly administered (2 min each).Systemic anaphylactoid reactions following infusion of polygeline were completely prevented in volunteers by the same premedication (0.1 mg/kg dimethpyrindene and 10 mg/kg cimetidine). Life-threatening reactions could not be tested in human subjects, but were elicited in experimental animals (dogs). In this species which resembles man in its sensitivity against histamine, in plasma histamine levels and in response to polygeline life-threatening reactions were prevented or in especially severe cases diminished to such an extent by the premedication with H 1-+ H2-blockers that this premedication was finally judged to be very effective against histamine-release responses of any grade of severity.To confirm this clinically very important hypothesis more clinical trims in patients at risk for anaphylactoid reactions to drugs are urgently needed.

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“…The determination of histamine concentrations in plasnia has important applications [14,20,21.27,30.43 54]; because of the short halflife time of histamine (c. 2 min.) [55,56] this is especially important in the field of controlled studies, in which it is possible to collect blood samples at regular times. However, in a meta-analysis evaluation about the role of histamine as a mediator in septic/endotoxic shock, threequarters of the relevant studies are quoted as being an unreliable assay for measuring histamine in human 349 [ [47,56], plasma and the authors conclude 'it is irrational to develop theories about any pathomechanism of histamine release before this error has been carefully excluded" [51].…”

Section: Introductionmentioning

confidence: 99%

“…[55,56] this is especially important in the field of controlled studies, in which it is possible to collect blood samples at regular times. However, in a meta-analysis evaluation about the role of histamine as a mediator in septic/endotoxic shock, threequarters of the relevant studies are quoted as being an unreliable assay for measuring histamine in human 349 [ [47,56], plasma and the authors conclude 'it is irrational to develop theories about any pathomechanism of histamine release before this error has been carefully excluded" [51]. Also the discrepancy between recently reported reference values for histamine in human plasma (Table 1: [1980][1981][1982][1983][1984][1985][1986][1987][1988][1989]; n = 25: CV = 67%) suggests that besides possible sample collection problems [40] and biorhythmic differences [12], inaccuracy and imprecision may exist, leading to unreliable reports.…”

Section: Introductionmentioning

confidence: 99%

Determination of histamine in human plasma: the European external quality control study 1988

Oosting¹,

Neugebauer

Keyzer

et al. 1990

Clin Experimental Allergy

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SummaryThere is an increasing interest in measuring human plasma histamine levels in various clinical conditions. A variety of 'old' and newly developed techniques are applied to meet this demand. However, the discrepancy between reported reference values for histamine in human plasma measured using this variety of techniques, suggests the existence of a certain degree of inaccuracy and imprecision. We therefore organized an external quality control study on the reliability of current histamine determinations in European laboratories. Three lyophilized plasma quality control samples, in duplicate, covering the normal and pathological range of histamine concentrations {0-45 nmol/l), two different aqueous histamine standard samples and one solvent sample were sent to 10 laboratories for the analysis of their histamine content. The following methods were used: gas chromatography-mass spectrometry (« = 2), enzymatic single isotopic assay («= 1), fiuorometric-fluoroenzymatic assay (« = 3). radioimmunoassay (« = 3) and high performance liquid chromatography {n = 2). The study was performed and evaluated according to the approved recommendations (1983) ofthe International Federation of Clinical Chemistry (IFCC). The target values ±s.d. ofthe three plasma samples were: 39-5±4-6 nmol/l (CV=ll-6%), 2 3 + 2-2 nmo!/l (CV-96%) and 8-9+1-5 nmol/l (CV=17%), respectively. The target values +s.d. ofthe two aqueous samples were: 0-9± 1-1 nmol/l (CV= 120%; true value: 0 00 nmol/l) and 10 2±0-5nmol/l(CV=5 3%; true value: 10 Onmol/l), respectively. A Youden plot oftwo unrelated plasma samples in the pathological range defined 7/11 results as accurate and precise. The Youden plot of the two unrelated aqueous samples only defined 6/11 results as accurate and precise. In general, estimating histamine concentrations within the normal range seemed to be the most difficult part of measuring histamine in human plasma samples. It is suggested to define reference standards, methods and laboratories for plasma histamine determinations.

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Fluorometric Histamine Determination in Canine Plasma under Normal Conditions, following Application of Exogenous Histamine, and during Histamine Release by Haemaccel

Cited by 50 publications

References 1 publication

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: Synopsis of three randomized controlled trials

Determination of histamine in human plasma: the European external quality control study 1988

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