Fluorometric Determination of Amphetamines with 3-Carboxy-7-hydroxycoumarin

Stewart, James T.; Lotti, D.M.

doi:10.1002/jps.2600600327

Cited by 14 publications

(2 citation statements)

References 4 publications

(1 reference statement)

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“…A fairly good cor- fluorescence intensity and the hallucinogenic potency in a series of amphetamines (23). One sensitive method for amphetamines is based on condensation of the amine group with acetylacetone and formaldehyde, yielding the familiar intensely fluorescent 1,4-dihydrolutidine derivative (668); another method uses 3-carboxy-7-hydroxycoumarin to form a highly fluorescent amine-carboxylate salt (900).…”

Section: Organic and Biologicalmentioning

confidence: 99%

Fluorometric analysis

White¹,

Weissler²

1972

Anal. Chem.

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Section: Organic and Biologicalmentioning

confidence: 99%

Fluorometric analysis

White¹,

Weissler²

1972

Anal. Chem.

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“…In addition, 3-carboxy-7-hydroxycoumarin has been used for the determination of amphetamines [18]. To the best of our knowledge, 7-hydroxycoumarin has not been used before for the determination of drugs.…”

Section: Introductionmentioning

confidence: 99%

Novel Spectrofluorimetric Method for the Determination of Perindopril Erbumine Based on Charge Transfer Reaction with 7-Hydroxycoumarin

Fael

Sakur

2015

J Fluoresc

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A novel, simple, selective and sensitive spectrofluorimetric method was developed and validated for the determination of perindopril erbumine using 7-hydroxycoumarin. Perindopril erbumine was found to react with 7-hydroxycoumarin in acetonitrile resulting in a new fluorescent product with about 58 nm blue shifted emission. The fluorescence of the complex was measured at 440 nm after excitation at 350 nm in acetonitrile. Under the optimum conditions, the fluorescence intensity was linear over a concentration range of 2.0-16.0 μg/mL (R(2) = 1) with a detection limit of 0.054 μg/mL. The proposed method was fully validated and successfully applied to the analysis of perindopril erbumine in pure form and tablets. Statistical comparison of the results obtained by the proposed and reference method revealed no significant differences in the performance of the two methods regarding the accuracy and precision respectively. The method was shown to be highly specific in the presence of indapamide, a diuretic that is commonly combined with perindopril erbumine. A proposal for the reaction pathway with 7-hydroxycoumarin was postulated.

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7‐Hydroxycoumarin‐3‐carboxylic acid (Umbelliferone‐3‐carboxylic acid)

Sabnis¹

2015

Handbook of Fluorescent Dyes and Probes

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Fluorometric Determination of Amphetamines with 3-Carboxy-7-hydroxycoumarin

Cited by 14 publications

References 4 publications

Fluorometric analysis

Fluorometric analysis

Novel Spectrofluorimetric Method for the Determination of Perindopril Erbumine Based on Charge Transfer Reaction with 7-Hydroxycoumarin

7‐Hydroxycoumarin‐3‐carboxylic acid (Umbelliferone‐3‐carboxylic acid)

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