Fluorescence ‘off–on–off’ signaling with zinc ensemble: a new array of investigating prevalence of ATP in liver cancer cells

Abstract

2-Hydroxy naphthaldehyde–picolylamine conjugate (NPAC) ensemble with Zn2+ (NPAC–Zn2+) has been synthesized for the selective recognition and estimation of ATP in human liver cancer cells.

An overview on the development of different optical sensing platforms for adenosine triphosphate (ATP) recognition

“…Furthermore, when ATP was added to this 68-Zn 2+ complex, the fluorescence was quenched significantly (68-Zn 2+ -ATP) due to the better binding affinity of ATP towards Zn 2+ . 102 It was found that sensors with dual sensing properties are able to detect ATP ions followed by the complexation with…”

“…Furthermore, when ATP was added to this 68-Zn 2+ complex, the fluorescence was quenched significantly ( 68-Zn 2+ -ATP ) due to the better binding affinity of ATP towards Zn 2+ . 102 It was found that sensors with dual sensing properties are able to detect ATP ions followed by the complexation with certain metal ions. It was reported that the red emission of a carbon dots–quercetin (CDs-QCT) system exhibited a dual-sensing property towards Zn 2+ and ATP ions.…”

Solvent-regulated fluorescence off–on signaling of Ni(ii) and Zn(ii) with the formation of two mononuclear complexes with an ATP detection ability by Zn(ii) assembly

“…[48][49][50] It is found that several Zn complexes based on thiocarbazole, pyrene, and naphthaldehyde have ATP detection efficacy. 51,52 However, no report of a simple Schiff-base Zn(II) complex being used as an effective ATP sensor has been found (Scheme 1).…”

Design and development of imidazo[4,5-f] [1,10] phenanthroline-Zn(ii) based fluorescent probes for specific recognition of ATP with tunable optical responses and probing the enzymatic hydrolysis of ATP by alkaline phosphatase

“…27 A higher or lower level of ATP causes symptoms such as hypoxia, hypoglycaemia, and Parkinson's disease, 28,29 whereas an elevated level of ATP is associated with various malignant tumors. 30 Several analytical methods, such as electrochemistry, 31 electrochemiluminescence, 32 surface-enhanced Raman scattering, 33 colorimetry, 34,35 and fluorimetry, [36][37][38] have been developed for ATP recognition. [39][40][41][42] Most of these ATP biosensors relied on the use of a specific aptamer, which can scarcely discriminate ATP from adenosine monophosphate (AMP).…”