An overview on the development of different optical sensing platforms for adenosine triphosphate (ATP) recognition

Abstract

Adenosine triphosphate (ATP), one of the biological anions plays crucial roles in several biological processes including energy transduction, cellular respiration, enzyme catalysis and signaling. ATP is a bioactive phosphate molecule,...

Chemiluminescence‐driven photoelectrochemical sensor: A mini review

“…necrosis, or apoptosis. To monitor and assess cell status and vitality, various ATP detection methods have been developed [93][94]. The utilization of split aptamers has emerged as a notable strategy for detecting ATP [95][96].…”

Water‐Soluble Triazolium Covalent Cages for ATP Sensing

“…However, due to the structural resemblance of ATP to other nucleotides, developing fluorophores for the selective detection of ATP is challenging. [3][4][5][6][7][8] Many ATP fluorescent sensors have relied on a direct binding assay by monitoring emission maxima and intensity changes through the direct interaction of ATP with the fluorescent probe. [9][10][11] However, this sensing mechanism is often limited in water due to the aggregation-caused quenching (ACQ) effect, [12] along with the competitive hydrogen bonding of the solvent and involvement of the hydroxyl groups of the sugar moiety.…”

Metal Ion-Regulated Fluorescent Sensor Array Based on Gold Nanoclusters for Physiological Phosphate Sensing

“…Up to now, great efforts have been devoted to developing sensors of physiological phosphates, especially for ATP and pyrophosphates (PPi). − However, most of the reported methods require sophisticated instrumentation or time-consuming detection processes. , Moreover, these PP sensors are mostly designed based on the “lock-and-key” strategy for detecting specific analytes, and it still remains a challenge to develop a chemosensor with sufficient specificity for one given phosphate because other structurally similar PPs may interfere with the detection. , To overcome these drawbacks, high-throughput sensor arrays have been considered as a feasible and promising approach. − Sensor arrays contain multiple channel-sensing elements and specialize in distinguishing subtle changes caused by multiple analytes with similar structures in a complex environment. − Sensing materials such as fluorescent dyes, quantum dots, and metal–organic frameworks have been employed to construct sensor arrays for PPs recently, ,− but these reported approaches still face several challenges. First, most reported arrays focus on the discrimination of ATP and its hydrolysates, , and few fluorescent sensors are capable of discriminating different PPs, especially nucleoside triphosphates (such as GTP, CTP, and UTP). , Second, the established arrays mostly rely on the assistance of statistical analysis, which limits rapid and on-site discrimination of phosphates. , Third, the practical quantitative detection ability of reported methods, especially in complicated biofluids, remains limited due to the severe interference from complex fluids. , To this end, it is highly desirable to develop new sensing strategies to achieve the on-site identification and quantitative detection of PPs.…”