Fluid manipulation on the micro‐scale: Basics of fluid behavior in microfluidics

Novotný, Jakub; Foret, František

doi:10.1002/jssc.201600905

Cited by 34 publications

(35 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to traditional batch encapsulation techniques (Khadka et al 2014;Niu et al 2017), the rising technology of microfluidics enables to control fluid flow at the microscopic scale (Squires 2005). Downscaling processes with a microfluidic device offer many advantages including the low cost and faster parallel analysis for formulation development using many various conditions in a single chip (Novotný and Foret 2017;Valencia et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Controlled and tunable polymer particles’ production using a single microfluidic device

Amoyav

Benny

2018

Appl Nanosci

View full text Add to dashboard Cite

Microfluidics technology offers a new platform to control liquids under flow in small volumes. The advantage of using smallscale reactions for droplet generation along with the capacity to control the preparation parameters, making microfluidic chips an attractive technology for optimizing encapsulation formulations. However, one of the drawback in this methodology is the ability to obtain a wide range of droplet sizes, from sub-micron to microns using a single chip design. In fact, typically, droplet chips are used for micron-dimension particles, while nanoparticles' synthesis requires complex chips design (i.e., microreactors and staggered herringbone micromixer). Here, we introduce the development of a highly tunable and controlled encapsulation technique, using two polymer compositions, for generating particles ranging from microns to nano-size using the same simple single microfluidic chip design. Poly(lactic-co-glycolic acid) (PLGA 50:50) or PLGA/polyethylene glycol polymeric particles were prepared with focused-flow chip, yielding monodisperse particle batches. We show that by varying flow rate, solvent, surfactant and polymer composition, we were able to optimize particles' size and decrease polydispersity index, using simple chip designs with no further related adjustments or costs. Utilizing this platform, which offers tight tuning of particle properties, could offer an important tool for formulation development and can potentially pave the way towards a better precision nanomedicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Controlled and tunable polymer particles’ production using a single microfluidic device

Amoyav

Benny

2018

Appl Nanosci

View full text Add to dashboard Cite

show abstract

“…In addition, the flowrate in microfluidic devices that particularly handle microparticles is very low with Reynolds number as defined in Eq. (2) being less than unity ,

true R e = ρ D_{h} u_{f} / η

…”

Section: Fundamentals Of Microfluidic and Magnetismmentioning

confidence: 99%

Microfluidics Based Magnetophoresis: A Review

Alnaimat¹,

Dagher²,

Mathew³

et al. 2018

The Chemical Record

117

View full text Add to dashboard Cite

Magnetophoresis, the manipulation of trajectory of micro-scale entities using magnetic forces, as employed in microfluidic devices is reviewed at length in this article. Magnetophoresis has recently garnered significant interest due to its simplicity, in terms of implementation, as well as cost-effectiveness while being efficient and biocompatible. Theory associated with magnetophoresis is illustrated in this review along with different sources for creating magnetic field gradient commonly employed in microfluidic devices. Additionally, this article reviews the state-of-the-art of magnetophoresis based microfluidic devices, where positive- and negative-magnetophoresis are utilized for manipulation of micro-scale entities (cells and microparticles), employed for operations such as trapping, focusing, separation, and switching of microparticles and cells. The article concludes with a brief outlook of the field of magnetophoresis.

show abstract

“…Since the flow inside the microfluidic channels is laminar and diffusion is relatively slow, on‐chip introduced reagents are not uniformly presented across the channel width . Thus, in most cases, implementation of mixers is required.…”

Section: In‐solution Strategymentioning

confidence: 99%

Recent strategies toward microfluidic‐based surface‐enhanced Raman spectroscopy

2017

View full text Add to dashboard Cite

Surface-enhanced Raman spectroscopy (SERS) is an extremely powerful analytical tool, which not only yields information about the molecular structure of the analyte in the form of characteristic vibrational spectrum but also gives sensitivities approaching those in fluorescence spectroscopy. The SERS measurement on the microfluidic platform provides possibility to manufacture the device with design perfectly fulfilling the needs of the application with minimal sample consumption. This review aims at describing basic strategies for SERS measurement in microfluidic devices published in the last decade and covers current trends in microfluidics with SERS detection in the field of bioanalysis and approaches toward on-line coupling of liquid-based separation techniques with SERS detection.

show abstract

Fluid manipulation on the micro‐scale: Basics of fluid behavior in microfluidics

Cited by 34 publications

References 92 publications

Controlled and tunable polymer particles’ production using a single microfluidic device

Controlled and tunable polymer particles’ production using a single microfluidic device

Microfluidics Based Magnetophoresis: A Review

Recent strategies toward microfluidic‐based surface‐enhanced Raman spectroscopy

Contact Info

Product

Resources

About