Fluid dynamics during embryo transfer

Grygoruk, Cezary; Kolodziejczyk, M; Gagan, Jerzy; Modliński, Jacek A.; Gajda, B.; Pietrewicz, Piotr; Mrugacz, Grzegorz

doi:10.1016/j.fertnstert.2011.05.034

Cited by 10 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the ET at the early stages of embryo development seems to be more favorable to the embryo viability than its later counterpart, unless the pressure-based catheters are used. The results of the present and the previous experiments demonstrated that the physical conditions created during ET are able to injure vital cell structures (2)(3)(4)11). The application of the microsyringe with a relatively small plunger diameter allowed us to reduce the pressure generated during ET (Fig.…”

Section: Figuresupporting

confidence: 62%

See 1 more Smart Citation

Influence of embryo transfer on embryo preimplantation development

Grygoruk¹,

Pietrewicz²,

Modliński

et al. 2012

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Section: Figuresupporting

confidence: 62%

“…Furthermore, the computer simulations revealed a significant shear stress, velocity difference, and pressure acting on embryos inside the catheter during the ejection phase of ET (3). At present, experiments have demonstrated that ET has been able to trigger morphological changes and apoptosis in the mouse blastocysts (4).…”

mentioning

confidence: 91%

Influence of embryo transfer on embryo preimplantation development

Grygoruk¹,

Pietrewicz²,

Modliński

et al. 2012

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

“…A large retrospective study showed that no movement of the air bubble occurs in more than 90% of cases when the catheter is loaded with a low amount of culture medium [18]. In the present study, a low fluid amount (20 μl) was used to load the catheter and a moderate injection speed was used, as recommended to avoid embryo displacement [17,19]: indeed we observed a slight movement of the air bubble (a few mm, for 30–60 seconds) in less than 10% of cases, confirming that the site of embryo release can be estimated by US air bubble detection with high reliability.…”

Section: Discussionmentioning

confidence: 86%

IVF outcome is optimized when embryos are replaced between 5 and 15 mm from the fundal endometrial surface: a prospective analysis on 1184 IVF cycles

Rovei¹,

Dalmasso²,

Gennarelli³

et al. 2013

Reprod Biol Endocrinol

View full text Add to dashboard Cite

BackgroundSome data suggest that the results of human in vitro fertilization (IVF) may be affected by the site of the uterine cavity where embryos are released. It is not yet clear if there is an optimal range of embryo-fundus distance (EFD) within which embryos should be transferred to optimize IVF outcome.MethodsThe present study included 1184 patients undergoing a blind, clinical-touch ET of 1–2 fresh embryos loaded in a soft catheter with a low amount of culture medium. We measured the EFD using transvaginal US performed immediately after ET, with the aim to assess (a) if EFD affects pregnancy and implantation rates, and (b) if an optimal EFD range can be identified.ResultsDespite comparable patients’ clinical characteristics, embryo morphological quality, and endometrial thickness, an EFD between 5 and 15 mm allowed to obtain significantly higher pregnancy and implantation rates than an EFD above 15 mm. The abortion rate was much higher (although not significantly) when EFD was below 5 mm than when it was between 5 and 15 mm. Combined together, these results produced an overall higher ongoing pregnancy rate in the group of patients whose embryos were released between 5 and 15 mm from the fundal endometrial surface.ConclusionsThe site at which embryos are released affects IVF outcome and an optimal EFD range exists; this observations suggest that US-guided ET could be advantageous vs. clinical-touch ET, as it allows to be more accurate in releasing embryos within the optimal EFD range.

show abstract

“…Local pressure changes during ET are considered as a possible factor creating favorable conditions for expulsion of the embryos from the uterine cavity while impairing embryo viability. 52,53 It is recommended that ET should be performed with a minimum ejection speed to protect the embryo(s) from the pressure gradient changes and to prevent embryo expulsion.…”

Section: Embryo Expulsionmentioning

confidence: 99%

Practice of Embryo Transfer: Recommendations During and After

Tıraş

Cenksoy

2014

Semin Reprod Med

View full text Add to dashboard Cite

Many patient and embryo factors influence the outcome of assisted reproductive technology (ART) treatment. The predictors for a successful ART cycle include female age, ovarian reserve, embryo quality, endometrial receptivity, and embryo transfer (ET) technique. ET, the final step of ART, has recently been noted as a crucial step affecting ART success. Variables affecting pregnancy rates following ET include ultrasound guidance, ease of ET transfer, catheter type, transfer and catheter-loading technique, blood or mucus effects, retained embryos, trial transfer, the physician's experience, and catheter tip placement. Despite the lack of consensus regarding the optimal ET technique, it is generally recommended that during ET, the disruption of the endometrium and the induction of uterine contractions should be avoided. The exposure of embryos to the ambient conditions should be minimized, and the embryo(s) should be placed at an optimal position within the fundal region of the uterine cavity.

show abstract

Fluid dynamics during embryo transfer

Cited by 10 publications

References 8 publications

Influence of embryo transfer on embryo preimplantation development

Influence of embryo transfer on embryo preimplantation development

IVF outcome is optimized when embryos are replaced between 5 and 15 mm from the fundal endometrial surface: a prospective analysis on 1184 IVF cycles

Practice of Embryo Transfer: Recommendations During and After

Contact Info

Product

Resources

About