Practice of Embryo Transfer: Recommendations During and After

Tıraş, Bülent; Cenksoy, Pinar Ozcan

doi:10.1055/s-0034-1375181

Cited by 18 publications

(5 citation statements)

References 70 publications

(68 reference statements)

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“… 16 Other causes include traumatic contact with the cervix or the endometrium, resulting in bleeding. 17 Our findings supported the results of prior studies. 16 , 18 , 19 Thus, it is recommended to perform embryo transfer under atraumatic conditions without the presence of blood or mucus to increase the likelihood of implantation.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have shown that mucus can significantly impact the outcome of assisted reproductive technology (ART) by causing mechanical obstruction of the catheter opening, resulting in embryo retention. 17,[23][24][25] In our study, however, the linear regression model showed that there was no significant association between the presence of mucus during embryo transfer and the success of IVF-ET. This observation aligns with what other studies have found.…”

Section: Discussioncontrasting

confidence: 84%

See 1 more Smart Citation

Factors Affecting the Outcomes of First in vitro Fertilization and Embryo Transfer: A Retrospective Investigation

Muhaidat,

Karam,

Nabhan

et al. 2023

IJWH

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Background The outcome of embryo transfer (ET) is multifactorial. A variety of patient-related, procedural-related, and operator-related factors are known to play a role. This study aims to evaluate the outcomes of ET and determine the factors that affect the outcome. Methods The study involved a retrospective design involving 300 first in vitro fertilization and embryo transfer (IVF-ET) cycles between 2011 and 2021. The outcome included 155 unsuccessful cycles and 145 successful IVF-ET leading to pregnancy. The outcomes were examined for different variables, including age, weight, height, body mass index, cause of infertility, number of embryos fertilized during the cycle, day of ET, whether the embryo was frozen, presence of blood or mucus during the procedure, the use of a stylet, tenaculum, uterine sound/dilator, and catheter type. Logistic regression was used to analyze factors affecting the outcomes of ET. Results The mean age was 27.84 ± 3.77 years. Patients who had blood during the procedure (32.9% vs 17.2%, p = 0.002), mucus (31% vs 20.7%, p = 0.049), or used the tenaculum (16.8% vs 6.9%, p = 0.012) were more likely to have unsuccessful IVF-ET. Logistic regression to adjust for related factors revealed that the presence of blood (AOR = 2.21, 95% CI 1.04 to 4.66, p = 0.038) during the ET had a higher likelihood of an unsuccessful outcome. Conclusion This study showed that the presence of blood during the ET cycle influenced clinical pregnancy. This highlights the importance of performing the procedure under atraumatic conditions. Level of Evidence Level III; retrospective comparative study.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 84%

Factors Affecting the Outcomes of First in vitro Fertilization and Embryo Transfer: A Retrospective Investigation

Muhaidat,

Karam,

Nabhan

et al. 2023

IJWH

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“…It has been hypothesized that blastocyst stage ET would permit the identification of embryos that could maintain their developmental process and, thus, allow the recruitment of good quality embryos with enhanced developmental ability. Therefore, it has been suggested that the blastocyst transfer at day 5 would succeed the highest pregnancy rates with the least number of embryos ( 5 , 6 , 7 ) . It is well known that growth and blastocysts at the 8-cell stage need a more complex environment, but the recent formulation of highly specialized media has permitted the preservation of blastocysts in vitro ( 8 , 9 , 10 ) .…”

Section: Introductionmentioning

confidence: 99%

Day 3 embryo transfer versus day 5 blastocyst transfers: A prospective randomized controlled trial

Hatırnaz¹,

2017

tjod

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Objective:This study aimed to show whether transferring day 5 embryos resulted in higher implantation and pregnancy rates than transferring day 3 embryos in Turkish women undergoing an intracytoplasmic sperm injection (ICSI) cycle.Materials and Methods:A total of 190 women who had ICSI after retrieval of more than four oocytes on the day of fertilization check were randomly assigned to undergo embryo transfer either on day 3 or day 5.Results:Day 3 and day 5 transfers were statistically similar with respect to the age of woman (p=0.107), duration of infertility (p=0.528), cause of infertility (p=0.850), number of collected oocytes (p=0.119), number of metaphase II oocytes (p=0.178), number of fertilized oocytes (p=0.092), and number of transferred embryos (p=0.556). The number of grade 1 embryos was significantly higher in day 5 transfers than in day 3 transfers (p=0.001). Day 3 and day 5 embryo transfers had statistically similar implantation, clinical pregnancy, twinning, and live birth rates (p=0.779, p=0.771, p=0.183, and p=0.649, respectively). The live birth rates in singleton pregnancies conceived after day 3 and day 5 embryo transfers were statistically similar (p=0.594).Conclusion:The efficacy of blastocyst transfer is not inferior to that of embryo transfer on cleavage stage. Performing blastocyst transfer may have benefits because it is associated with acceptable pregnancy rates and morphologic assessment on day 3 has limited predictive value for subsequent embryonic development.

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“…However, a successfully implanted embryo can be found in a different area than expected for different reasons. According to Tiras & Cenksoy (2014), there is a movement of the air bubbles soon after the placement of the embryos in the uterine cavity that can influence the rates of implantation and pregnancy. The movement of the embryos towards the cervical canal may be associated with lower clinical pregnancy rates, whereas movement towards the uterine fundus may be associated with higher pregnancy rates.…”

Section: Discussionmentioning

confidence: 99%

Embryo placement in IVF and reproductive outcomes: a cohort analysis and review

Santos¹,

Silva²,

Barbosa³

et al. 2019

JBRA Assisted Reproduction

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Objective: The objective of the present study was to determine the influence of the embryo placement depth on the endometrial cavity in relation to the reproductive outcomes, after frozen-thawed embryo transfer performed under transabdominal ultrasound guidance. Methods: Retrospective cohort study that evaluated the influence of the embryo placement depth in the endometrial cavity in relation to the reproductive outcomes of patients submitted to cryotransfer cycles at a private assisted reproduction clinic, from 2012 to 2017. The patients were classified according to three variables: <10mm, 10 to 15mm and >15mm. The primary outcome was clinical pregnancy, and the secondary outcomes were miscarriage, ongoing pregnancy and live birth. The data was summarized as relative risk, with a 95%CI. Results: Clinical and ongoing pregnancy rates were higher in the 10-15mm and >15mm Groups, when compared to the <10mm Group; there was no statistical difference between the groups in terms of miscarriage and live birth rates. We performed a subsequent analysis, using the same sample of patients, comparing only the <10mm and ≥10mm variables. The ≥10mm Group had better reproductive outcomes, with higher clinical and ongoing pregnancy rates. Conclusion: Pregnancy rates are influenced by embryo transfer site, and better results can be achieved when the tip of the catheter is placed in the central area of the endometrial cavity, especially when the distance from the endometrial fundus is >10mm.

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Practice of Embryo Transfer: Recommendations During and After

Cited by 18 publications

References 70 publications

Factors Affecting the Outcomes of First in vitro Fertilization and Embryo Transfer: A Retrospective Investigation

Factors Affecting the Outcomes of First in vitro Fertilization and Embryo Transfer: A Retrospective Investigation

Day 3 embryo transfer versus day 5 blastocyst transfers: A prospective randomized controlled trial

Embryo placement in IVF and reproductive outcomes: a cohort analysis and review

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