Flow injection analysis of doxycycline or chlortetracycline in pharmaceutical formulations with pulsed amperometric detection

Charoenraks, Thiraporn; Palaharn, Sanit; Grudpan, Kate; Siangproh, Weena; Chailapakul, Orawon

doi:10.1016/j.talanta.2004.04.036

Cited by 42 publications

(16 citation statements)

References 32 publications

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“…Previous works have shown that pulsed potential cleaning, as carried out in PAD technique, is an effective method for electropolishing in analysis of tetracycline [35], doxycycline and chlortetracycline [36]. Some authors have reported use of the PAD technique for BDD and GC electrodes [35,37].…”

Section: Electropolishing By Pad and Waveform Optimizationmentioning

confidence: 99%

Pulsed Amperometry for Anti-fouling of Boron-doped Diamond in Electroanalysis of β-Agonists: Application to Flow Injection for Pharmaceutical Analysis

Karuwan

Mantim

Chaisuwan

et al. 2006

Sensors

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This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixedpotential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 µM, 1.0-100 µM and 0.5-50 µM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

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Section: Electropolishing By Pad and Waveform Optimizationmentioning

confidence: 99%

Pulsed Amperometry for Anti-fouling of Boron-doped Diamond in Electroanalysis of β-Agonists: Application to Flow Injection for Pharmaceutical Analysis

Karuwan

Mantim

Chaisuwan

et al. 2006

Sensors

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“…Glassy carbon (Palomeque andOrtíz 2007, Pfaffen et al 2013), paraffinated graphite (Perantoni et al 2011), carbon paste (Dejmkova et al 2013), boron-doped diamond (Wangfuengkanagul et al 2004) and, particularly, gold (Palaharm et al 2003, Charoenraks et al 2004, Codognoto et al 2010) and screen-printed gold (Masawat and Slater 2007) were reported electrode materials. Electrode modification with metalloporphyrin (Gong et al 2003), cyclodextrin (Lomillo et al 2005), carbon nanotubes ), among others (Won et al 2013), have been reported.…”

Section: Amperometric Methodsmentioning

confidence: 99%

Voltammetric/amperometric screening of compounds of pharmacological interest

Doménech‐Carbó

Carvalho

Martini

et al. 2014

Reviews in Analytical Chemistry

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Voltammetric and amperometric methods for screening compounds of pharmacological interest are reviewed on the basis of the types of electrodes and analytical strategies. The scope of conventional voltammetric and amperometric methods has been considerably expanded in the last years due to the development of a plethora of modified electrodes, in particular, those involving nanocomposites. The application of solid state voltammetric techniques for pharmacological screening has been also reviewed.

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“…All three steps of PAD require the following: (a) the oxidation of analyte during the detection step; (b) the oxidative desorption of adsorbed detection products or solution impurities during the cleaning step; and (c) the cathodically dissolution of inert oxide product during reactivation step. Pulsed amperometric detection has been used for the sensitive detection of numerous compounds such as tetracycline [13] and chlortetracycline [14]. …”

Section: Flow-based Electrochemical Detectionmentioning

confidence: 99%