Flow-induced corrosion of absorbable magnesium alloy: In-situ and real-time electrochemical study

Wang, Juan; Jang, Yong-Seok; Wan, Guojiang; Giridharan, Venkataraman; Song, Guang‐Ling; Xu, Zhigang; Koo, Youngmi; Qi, Pengkai; Sankar, Jagannathan; Huang, Nan; Yun, Yeoheung

doi:10.1016/j.corsci.2015.12.020

Cited by 86 publications

(33 citation statements)

References 56 publications

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“…Three time constants can be assigned for the EIS plots of all the samples. For Zn and Mg, they consist of two capacitive loops at high and medium frequencies and one inductive loop at low frequencies [42,43], while for Fe, two capacitive loops at high and low frequencies can only be identified, probably because the scanning frequency range does not suffice to cover the slower steps. Therefore, two types of equivalent circuits models (embedded in each Nyquist plot) were applied to decode their components.…”

Section: Transient Electrochemical Corrosion Behaviormentioning

confidence: 98%

Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

et al. 2016

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Section: Transient Electrochemical Corrosion Behaviormentioning

confidence: 98%

Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

et al. 2016

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“…In an in-situ experiment, the corrosion of an Mg alloy was electrochemically monitored (real time) in a vascular bioreactor. It was observed that the flow-induced shear stress caused faster mass and electron transfer of the alloy during corrosion [39]. These two examples suggest that certain in-vivo conditions affect the corrosion behavior of absorbable metals and indicate the importance of correlating the results obtained by in-vitro experiments with those of in-vivo tests.…”

Section: Introductionmentioning

confidence: 93%

“…Over the past five years, several systems have been developed to study the behavior of absorbable metals during corrosion in realtime. By developing a set-up composed of a vascular bioreactor (with circulation of simulated body fluid to simulate the dynamic in-vivo condition) and an electrochemical cell (attached to a potentiostat), (Figure 6b) Wang et al [39] investigated the corrosion of a Mg alloy in-situ. Another electrochemical-based system was developed to monitor the real-time corrosion of Mg, namely the corrosion characterization system [67].…”

Section: Electrochemical-based Monitoring Systemmentioning

confidence: 99%

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.

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“…Additionally, there is always a steep concentration gradient around the degradation interface, that is, alkaline pH is rapidly refreshed by circulating medium. The fresh metal surface and medium replacement promoted degradation [32]. Because of the fast degradation, the part of the Mg that exposed to the lumen fractured at the 3rd day (Fig.…”

Section: Resultsmentioning

confidence: 99%

Ex vivo blood vessel bioreactor for analysis of the biodegradation of magnesium stent models with and without vessel wall integration

Wang

Liu

et al. 2017

Acta Biomaterialia

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Current in vitro models fail in predicting the degradation rate and mode of magnesium (Mg) stents in vivo. To overcome this, the microenvironment of the stent is simulated here in an ex vivo bioreactor with porcine aorta and circulating medium, and compared with standard static in vitro immersion and with in vivo rat aorta models. In ex vivo and in vivo conditions, pure Mg wires were exposed to the aortic lumen and inserted into the aortic wall to mimic early- and long-term implantation, respectively. Results showed that: 1) Degradation rates of Mg were similar for all the fluid diffusion conditions (in vitro static, aortic wall ex vivo and in vivo); however, Mg degradation under flow condition (i.e. in the lumen) in vivo was slower than ex vivo; 2) The corrosion mode in the samples can be mainly described as localized (in vitro), mixed localized and uniform (ex vivo), and uniform (in vivo); 3) Abundant degradation products (MgO/Mg(OH)2 and Ca/P) with gas bubbles accumulated around the localized degradation regions ex vivo, but a uniform and thin degradation product layer was found in vivo. It is concluded that the ex vivo vascular bioreactor provides an improved test setting for magnesium degradation between static immersion and animal experiments and highlights its promising role in bridging degradation behavior and biological response for vascular stent research.

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Flow-induced corrosion of absorbable magnesium alloy: In-situ and real-time electrochemical study

Cited by 86 publications

References 56 publications

Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

Ex vivo blood vessel bioreactor for analysis of the biodegradation of magnesium stent models with and without vessel wall integration

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