Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

Chen, Yingqi; Zhang, Wentai; Maitz, Manfred F.; Chen, Meiyun; Zhang, Heng; Mao, Jinlong; Zhao, Yuancong; Huang, Nan; Wan, Guojiang

doi:10.1016/j.corsci.2016.05.039

Cited by 115 publications

(64 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In consistent with the elevation of the pH values, Mg ions in the D1 leaching solutions were increased several 10 folds compared to those in extract medium (Table ), demonstrating that 1 day immersion caused a massive degradation of the Mg‐materials. Again, the prolonging extraction did not further elevate the Mg ions so much, apparently due to the formation of the protective corrosive deposit layer . Additionally, the AZ31 appeared to alkalize extract medium stronger but release less Mg ions than the pure Mg materials did (Table ).…”

Section: Resultsmentioning

confidence: 96%

Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype

et al. 2018

Self Cite

View full text Add to dashboard Cite

Phenotype switching is a characteristic response of vascular smooth muscle cells (vSMCs) to the dynamic microenvironment and contributes to all stages of atherosclerotic plaque. Here, we immersed pure magnesium and AZ31 alloy in the completed medium under cell culture condition, applied the resultant leaching extracts to the isolated contractile rat aortic vSMCs and investigated how vSMCs phenotypically responded to the degradation of the magnesium-based stent materials. vSMCs became more proliferative and migratory but underwent more apoptosis when exposed to the degradation products of pure magnesium; while the AZ31 extracts caused less cell division but more apoptosis, thus slowing cell moving and growing. Noticeably, both leaching extracts dramatically downregulated the contractile phenotypic genes at mRNA and protein levels while significantly induced the inflammatory adhesive molecules and cytokines. Exogenously added Mg ions excited similar transformations of vSMCs. With the liberation or supplementation of Mg 2+ , the expression patterns of the pro-contractile transactivator myocardin and the pro-inflammatory transcriptional factor kruppel-like factor 4 (KLF4) were reversed. Overall, the degradation of the Mg-based materials would evoke a shift of the contractile vSMCs to an inflammatory phenotype via releasing Mg ions to induce a transition from the phenotypic control of vSMCs by the myocardin to that by the KLF4.How to cite this article: Zhou Y, Liu X, Huang N, Chen Y. 2019. Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype. J Biomed Mater Res Part B 2019:107B:988-1001.

show abstract

Section: Resultsmentioning

confidence: 96%

Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chen et al [15] compared the corrosion behavior of Zn, Fe and Mg in a long-term course in vitro. They observed that by increasing immersion time the corrosion rate of Zn developed faster than Fe and Mg, which is justified by the occurrence of localized corrosion in the surface of Zn samples.…”

Section: Disadvantages Of Zn and Its Alloysmentioning

confidence: 99%

“…In addition to the structural role of Mg, Fe, Zn, and their alloys as an implant device, they play important roles in many metabolic reactions and biological mechanisms of the body and consequently reduce the healing duration [15]. That is the reason they are named nutrient metals (NMs) [14,16].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

View full text Add to dashboard Cite

Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

show abstract

“…There is no hydrogen produced during the whole corrosion process. The reaction equations are as follows [30,31] :…”

Section: Corrosion Behaviormentioning

confidence: 99%

“…The chemical properties of zinc are more stable than magnesium but more active than iron. The degradation rate of zinc will not be too fast or too slow, so it is a better candidate for a medical biomaterial [19,20] . Besides, zinc is also one of the essential trace elements and plays a very important role in the human body [21] .…”

mentioning

confidence: 99%

Preparation and properties of open-cell zinc foams as human bone substitute material

Zhang

Huang

et al. 2019

China Foundry

View full text Add to dashboard Cite

M edical metal materials have good mechanical properties and biocompatibility, and have been widely used as human hard tissue repair and replacement materials [1-3]. However, clinical studies have found that many medical metal materials do not match the elastic modulus of human bones, which will produce "stress shielding" phenomenon when implanted in the human body, resulting in loose or broken implants [4-6]. To solve the above problems, scholars have proposed a method of introducing pores into the medical metal materials [7,8]. The density, strength, and modulus of elasticity of porous metal materials can be adjusted by pore size and porosity, thus "stress shielding" can be alleviated or eliminated [9,10]. Porous structure and rough surface are conducive to the adhesion, proliferation, and differentiation of osteocytes, and promote the growth of new osteocytes into the pore [11,12]. Because the pore structure of foam metals is three-dimensionally connected, the body fluids and nutrients can be circulated, promoting tissue regeneration and reconstruction, and quickening the healing process [13,14]. At present, titanium foam and tantalum foam are often used to replace bone tissue. It should be pointed

show abstract

Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline

Cited by 115 publications

References 55 publications

Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype

Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Preparation and properties of open-cell zinc foams as human bone substitute material

Contact Info

Product

Resources

About