Flexible Hybrid Electronics for Digital Healthcare

Ma, Yinji; Zhang, Yingchao; Cai, Shisheng; Han, Zhiyuan; Liu, Xin; Wang, Fengle; Cao, Yu; Wang, Zhouheng; Li, Hangfei; Chen, Yi-Hao; Feng, Xue

doi:10.1002/adma.201902062

Cited by 408 publications

(241 citation statements)

References 208 publications

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“…107 Aiming to balance the invasiveness and high selectivity, researchers have kept optimizing the bio-electrodes for PNS from traditional intraneural electrodes such as Michigan and Utah electrodes, to extraneural electrodes such as cuff electrodes, PI-based electrodes. [108][109][110][111] Figure 3i shows a very recently developed 3D twining electrode, 112 which can self-climb onto the peripheral nerve from a two-dimension state with the aid of the shape memory effect. More importantly, the 3D twining electrode can form a flexible and conformal neural interface, which can reduce the inflammation of the nerve tissue without compromising the recording SNR, and it has showed potential in clinical application.…”

Section: Bioelectrical Signals Monitoringmentioning

confidence: 99%

Flexible inorganic bioelectronics

Chen¹,

et al. 2020

Self Cite

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Flexible inorganic bioelectronics represent a newly emerging and rapid developing research area. With its great power in enhancing the acquisition, management and utilization of health information, it is expected that these flexible and stretchable devices could underlie the new solutions to human health problems. Recent advances in this area including materials, devices, integrated systems and their biomedical applications indicate that through conformal and seamless contact with human body, the measurement becomes continuous and convenient with yields of higher quality data. This review covers recent progresses in flexible inorganic bio-electronics for human physiological parameters' monitoring in a wearable and continuous way. Strategies including materials, structures and device design are introduced with highlights toward the ability to solve remaining challenges in the measurement process. Advances in measuring bioelectrical signals, i.e., the electrophysiological signals (including EEG, ECoG, ECG, and EMG), biophysical signals (including body temperature, strain, pressure, and acoustic signals) and biochemical signals (including sweat, glucose, and interstitial fluid) have been summarized. In the end, given the application property of this topic, the future research directions are outlooked.

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Section: Bioelectrical Signals Monitoringmentioning

confidence: 99%

Flexible inorganic bioelectronics

Chen¹,

et al. 2020

Self Cite

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“…Especially in the last 2 years, it has received great attention. According to different detection methods and analysis principles, these biomedical applications can be divided into four categories: (1) cell analysis based on Coulter's counting principle and cell imaging technology for analysis of red cells, white cells, and tumor cells [10][11][12][13][14][15][16]; (2) biochemical analysis based on various enzyme reactions for analysis of blood glucose, electrolytes, and other nutrients in the human body [17][18][19][20];…”

Section: Introductionmentioning

confidence: 99%

The review of Lab‐on‐PCB for biomedical application

et al. 2020

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Prevention of infectious diseases, diagnosis of diseases, and determination of treatment options all rely on biosensors to detect and analyze biomarkers, which are usually divided into four parts: cell analysis, biochemical analysis, immunoassay, and molecular diagnosis. However, traditional biosensing devices are expensive, bulky, and require a lot of time to detect, which also limited its application in resource‐limited areas. In recent years, Lab‐on‐PCB, which combines biosensing technology and PCB technology, has been widely used in biomedical applications due to its high integration, personalized design, and easy mass production. Among these Lab‐on‐PCB sensing devices, the PCB circuit plays an important role. It can be directly used as a resistance sensor to count cells, and also used as a control device to automatically control the detection device. Flexible PCBs can be used to make wearable medical biosensors. In addition, due to the high degree of integration of the PCB circuit, Lab‐on‐PCB can perform multiple inspections on the same platform, which reduces the inspection time equivalently. Therefore, in this review paper, we discuss the application of Lab‐on‐PCB in four analysis methods of cell analysis, biochemical analysis, immunoassay, and molecular diagnosis, and give some suggestions for improvement and future development trends at the end.

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“…One effective strategy to overcome this mismatch is to integrate the functional inorganic electronic material in a stretchable format [6][7][8][9][10][11][12] at strategic locations on a soft polymer substrate by advanced transfer printing techniques [13][14][15][16]. Due to the unique mechanical properties of FIEDs, they can have conformal contacts with biological tissues under complex deformations, which enable the real-time monitoring of human vital signs for early diagnosis [17]. In the past decade, researchers have demonstrated several flexible real-time health monitoring devices to measure human vital signs including body temperature [4,18], blood glucose [19][20][21], blood oxygen [22], skin hydration [3], blood flow [2], brain electrophysiological signal [23,24], electrocardiography (ECG) [25], etc.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Thermal Management of Flexible Inorganic Electronics

Chen

Zhao³

et al. 2020

Micromachines

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Flexible inorganic electronic devices (FIEDs) consisting of functional inorganic components on a soft polymer substrate have enabled many novel applications such as epidermal electronics and wearable electronics, which cannot be realized through conventional rigid electronics. The low thermal dissipation capacity of the soft polymer substrate of FIEDs demands proper thermal management to reduce the undesired thermal influences. The biointegrated applications of FIEDs pose even more stringent requirements on thermal management due to the sensitive nature of biological tissues to temperature. In this review, we take microscale inorganic light-emitting diodes (μ-ILEDs) as an example of functional components to summarize the recent advances on thermal management of FIEDs including thermal analysis, thermo-mechanical analysis and thermal designs of FIEDs with and without biological tissues. These results are very helpful to understand the underlying heat transfer mechanism and provide design guidelines to optimize FIEDs in practical applications.

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Flexible Hybrid Electronics for Digital Healthcare

Cited by 408 publications

References 208 publications

Flexible inorganic bioelectronics

Flexible inorganic bioelectronics

The review of Lab‐on‐PCB for biomedical application

Recent Advances on Thermal Management of Flexible Inorganic Electronics

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