A wide variety of low‐dimensional nanomaterials with excellent properties can meet almost all the requirements of functional materials for information sensing, processing, and feedback devices. Low‐dimensional nanomaterials are becoming the star of hope on the road to pursuing human–machine–thing natural interactions, benefiting from the breakthroughs in precise preparation, performance regulation, structural design, and device construction in recent years. This review summarizes several types of low‐dimensional nanomaterials commonly used in human–machine–thing natural interactions and outlines the differences in properties and application areas of different materials. According to the sequence of information flow in the human–machine–thing interaction process, the representative research progress of low‐dimensional nanomaterials‐based information sensing, processing, and feedback devices is reviewed and the key roles played by low‐dimensional nanomaterials are discussed. Finally, the development trends and existing challenges of low‐dimensional nanomaterials in the field of human–machine–thing natural interaction technology are discussed.