Flexible and self-healing electrochemical hydrogel sensor with high efficiency toward glucose monitoring

Liang, Zhen; Zhang, Jieyu; Wu, Can; Hu, Xuefeng; Lu, Yuhui; Wang, Guangfeng; Yu, Fei; Zhang, Xiaojun; Wang, Yunbing

doi:10.1016/j.bios.2020.112105

Cited by 82 publications

(61 citation statements)

References 29 publications

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“…This review aims to investigate, how hydrogels contribute to improving these parameters. [23] (PEG methacrylate) Dye, protein, Oligonucleotide Fluorescence Covalent, Diels-Alder cycloaddition [50,51] Chitosan Enzymes Chromogenic (indigo) Covalent, amide bond [54] Chitosan, dextran Glucose Electrochemical Electrostatic [76] Responsive Hydrogels Acrylic acid and dimethylaminoethyl methacrylate Urea Piezoresistive pressure sensor Encapsulation [90] Shape-memory DNA film pH, Ag + /cysteine Photonic crystal Hybridization [93] Poly(methyl methacrylate-co-methacrylic acid)…”

Section: Biosensingmentioning

confidence: 99%

“…The flexible nature with additional self-healing properties yielded an excellent system for potential application as a continuous glucose monitoring system. [76] The embedding of larger objects in a hydrogel was also performed with silver nanoclusters and a DNA hydrogel for the detection of hydroxyl radicals. Silver nanoclusters were synthesized in situ and stabilized inside a DNA hydrogel, whereby cysteinerich sequences interacted with silver ions which were then reduced to fluorescent nanoclusters.…”

Section: Encapsulation Matrixmentioning

confidence: 99%

Section: Encapsulation Matrixmentioning

confidence: 99%

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Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

170

132

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Hydrogels play an important role in the field of biomedical research and diagnostic medicine. They are emerging as a powerful tool in the context of bioanalytical assays and biosensing. In this context, this review gives an overview of different hydrogels and the role they adopt in a range of applications. Not only are hydrogels beneficial for the immobilization and embedding of biomolecules, but they are also used as responsive material, as wearable devices, or as functional material. In particular, the scientific and technical progress during the last decade is discussed. The newest hydrogel types, their synthesis, and many applications are presented. Advantages and performance improvements are described, along with their limitations.

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Section: Biosensingmentioning

confidence: 99%

Section: Encapsulation Matrixmentioning

confidence: 99%

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Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

170

132

View full text Add to dashboard Cite

show abstract

“…The majority of self-monitoring systems of blood glucose provides only point measurements without providing essential information such as glucose trend and daily peaks [77]. Because of this the demand for smart continuous glucose sensors has increased very much in the last years and interesting solutions involving hydrogelbased sensors have been proposed [78].…”

Section: Physicochemical Sensormentioning

confidence: 99%

Progress in hydrogels for sensing applications: a review

Pinelli

Magagnin

Rossi

2020

Materials Today Chemistry

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There are several developments taking place in the field of sensors driven by the world today requirements. One of the most important novelties of the last two decades in the field is represented by the hydrogel-based sensors which constitute a wide family of innovative smart sensing devices relevant for many different applications. Hydrogels in fact are hydrophilic, biocompatible and highly water swellable polymer networks able to convert chemical energy into mechanical energy, with the great peculiarity to be able to respond to external stimuli. These characteristics have ensured them considerable recognition as valuable tool for smart sensing and diagnostics. The aim of this review is to focus on the advances obtained in the field in the last ten years.

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“…Apart from flexibility, self-healing ability of materials is interesting to integrate with soft or modern electrochemical sensors [96,116]. An example of a wearable potentiometric pH sensor was proposed in form of cables which can easily be knitted into textile ( Figure 5D) [115].…”

Section: Developing Electrolyte Sensorsmentioning

confidence: 99%

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

2020

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Personal biosensors and bioelectronics have been demonstrated for use in out-of-clinic biomedical devices. Such modern devices have the potential to transform traditional clinical analysis into a new approach, allowing patients or users to screen their own health or warning of diseases. Researchers aim to explore the opportunities of easy-to-wear and easy-to-carry sensors that would empower users to detect biomarkers, electrolytes, or pathogens at home in a rapid and easy way. This mobility would open the door for early diagnosis and personalized healthcare management to a wide audience. In this review, we focus on the recent progress made in modern electrochemical sensors, which holds promising potential to support point-of-care technologies. Key original research articles covered in this review are mainly experimental reports published from 2018 to 2020. Strategies for the detection of metabolites, ions, and viruses are updated in this article. The relevant challenges and opportunities of applying nanomaterials to support the fabrication of new electrochemical biosensors are also discussed. Finally, perspectives regarding potential benefits and current challenges of the technology are included. The growing area of personal biosensors is expected to push their application closer to a new phase of biomedical advancement.

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Flexible and self-healing electrochemical hydrogel sensor with high efficiency toward glucose monitoring

Cited by 82 publications

References 29 publications

Hydrogels and Their Role in Biosensing Applications

Hydrogels and Their Role in Biosensing Applications

Progress in hydrogels for sensing applications: a review

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

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