Flaxseed and Vitamin E Exert Synergic Antioxidant Action on Diabetic Nephropathy in Experimental Diabetes

Through this research, our main focus was: to investigate the biochemical brain metabolites (NAA-N-acetylaspartate, GABA-Gama-Aminobutyric Acid, Asp-Aspartate, CR-Creatine, Gln-Glutamine, GPC-Glicerophosphocholine, PC-Phosphocholine, PCr-Phosphocreatine, Tau-Taurine, N-MDA-N-Metyl-D-Aspartate, Serine, Glicine, Cho-Choline); the neuroimagistic, the brain biochemical and metabolic abnormalities in children and adolescents with epilepsy before and after treatment; to review the main antiepileptic medication administered to these patients; and to make some correlations with the results obtained through Magnetic Resonance (MR) Spectroscopy, for further proper early detection and intervention in children and adolescents with epilepsy. Our research was performed between 2010-2017, involving 45 children and adolescents with epilepsy. Also, the patients were evaluated through MR Spectroscopy at baseline and after pharmacotherapy. Through the MR Spectroscopy, we investigated key aspects of the brain function and metabolism. The antiepileptic medication was chosen according to the guides and the type of epileptic seizures. The efficacy of the chosen therapy was evaluated through the change of the relevant MR spectroscopy biochemical brain metabolites. Our results, showed statistically significant modified values and concentrations of the biochemical cerebral metabolites. Our research was a proof, which the evaluation of the biochemical brain metabolites through MR Spectroscopy is of high clinical utility in prevention, early detection and intervention in epilepsy in children and adolescents.

Section: Results Of the Metabolic Abnormalities Investigationsmentioning

confidence: 99%

Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment

Nussbaum¹,

Hogea²,

Folescu³

et al. 2018

“…These findings suggest that by reducing stress and psychological distress and through improving social support, it may be possible to enhance the quality of life of these patients [35][36][37][38][39][40][41][42][43].…”

Section: Resultsmentioning

confidence: 99%

Comparative Study Using Progesterone and Gynipral - Hexoprenaline Sulphate, with Effects in Postpone Preterm Birth

Hogea¹,

Sas²,

Poroch³

et al. 2018

The prevalence of preterm delivery is rising over time. Preterm delivery is a major cause of mortality in infants. In this study, we aimed to compare the frequency of psychological disorders among women with preterm delivery versus term delivery. In this study, psychological disorders in 25 women, who experienced preterm delivery (gestational age of less than 37 weeks) and in 25 women who had term delivery were examined, using Profile of Affective Distress (PAD) and Symptom Checklist-90 questionnaire (SCL-90). Women, who experienced preterm delivery were treated with progesterone from gestational age 24 and Gynipral - Hexoprenaline Sulphate (C22H30N2O10S), 48 hours before birth. The mean age of the participants was 26.26 for women with term delivery and 28.96 in preterm-delivery. The mean (PAD questionnaire) of the participants in the preterm delivery group being higher than that of the term delivery group, indicating a relevant tendency for the women in the first group to experience a strong affective disorder. The mean score of Symptom checklist-90 questionnaire (SCL-90) in women with term delivery was 49.16 (AS = 12.19) and 92.32 (AS = 29.71) in women with preterm delivery (p [ 0.001). The results reveal statistically significant differences in the short-term emotional reactions between the two groups of participants. Psychological disorders were higher in women with preterm delivery compared to those with term delivery.

“…It is important to monitor the level of magnesium in the child's body because once the deficiency become chronic, it can contribute to the development of conditions such as diabetes [24][25][26], insulin resistance, cardiovascular disease and ADHD [27].…”

Section: Resultsmentioning

confidence: 99%

Study of the Total Serum Concentration of Serrum Ionized Magnesium in Children and Adolescents from Sibiu Area

Antonescu¹,

Boţa²,

Serb³

et al. 2019

Magnesium is an essential nutrient for the living organisms and plays an important part in the prevention and treatment of many diseases. It is an enzymatic cofactor for more than 300 reactions. Magnesium is essential for regulating blood pressure, muscle contraction, cardiac excitability, insulin metabolism, vasomotor tonus. Studying the way in which serum magnesium concentration varies in children and adolescents in the Sibiu area according to the reference intervals we especially set for this area. The study is a retrospective one, using approximately 4900 data from the archives of the Medical Analysis Laboratory within the Sibiu Pediatric Clinical Hospital. Serum magnesium was dosed using the Konelab Prime 30i analyser. The data from the literature was used to compare the results. The reference ranges obtained in the current study were similar to the literature studied. The percentage of patients with magnesium concentration outside the reference ranges was roughly equal for all age groups. The difference was between 1 month and 2 year-old children with very few deviations from the reference range. The results of our study reflect more accurately the real reference range for the population in the Sibiu area, helping clinicians to establish a diagnosis as quickly and accurate as possible. These results were not significantly different from the literature studied.