Flaxseed and Prevention of Experimental Hypercholesterolemic Atherosclerosis

Prasad, Kailash; Thompson, Lilian U.; Cunnane, S. C.

doi:10.1201/9781439831915.ch13

Cited by 23 publications

(43 citation statements)

References 43 publications

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“…WBC counts were made using a STKS (Beckman Coulter) Automated Analyzer. WBC-CL was measured as previously described [1,32]. In short, 0.05 ml of blood was added to a tube containing Hank's balanced salt solution (HBSS) and luminol at a final concentration of 10 )4 M. Samples were placed in a luminometer (Auto Lumat LB953) for 10 min at 37°C and phagocytosis was initiated by addition of 0.1 ml (10 mg/ml) of opsonized zymosan.…”

Section: Chemiluminescent Activity Of Wbc (Wbc-cl)mentioning

confidence: 99%

Suppression of Oxidative Stress as a Mechanism of Reduction of Hypercholesterolemic Atherosclerosis by Cyclooxygenase Inhibitors

Lee

Prasad

2011

Int J Angiol

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Section: Chemiluminescent Activity Of Wbc (Wbc-cl)mentioning

confidence: 99%

Suppression of Oxidative Stress as a Mechanism of Reduction of Hypercholesterolemic Atherosclerosis by Cyclooxygenase Inhibitors

Lee

Prasad

2011

Int J Angiol

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Section: Discussionmentioning

confidence: 99%

“…20,21 SDG is implicated in the suppression of antioxidant conditions of ROS, such as hydroxyl radical, hydrogen peroxide superoxide anion, etc., in the chronic diseased body. 14,20,21 There are number of reports on radical scavenging potentials of SDG as measured by in vitro models. 6,22 However, no reports are available on their ability at in vivo conditions as number of factors decide the fate of these principal compounds in living systems.…”

Section: Discussionmentioning

confidence: 99%

Hepato-protective Potential of Hull Fraction from Indian Flaxseed Cultivar

et al. 2011

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Objective: Secoisolariciresinol diglucoside (SDG) isolated from hull fraction of Indian flaxseed cultivar was studied for its hepatoprotective potential by measuring the level of hepatic enzymes such as catalase, peroxidase and superoxide desmutase (SOD) upon feeding to albino rats. Material & Methods:The animals were grouped into five groups (n=5): The first group served as normal and received normal diet without treatment of toxin and hull fraction of flaxseed. The second group was named the control and received a regular commercial diet. The third, fourth and fifth groups were fed with normal diet and supplemented with hull fraction of flaxseed (150 and 250 μg/kg) and standard SDG (150 μg/kg), that was mixed with olive oil for 14 days.Results: Pretreatment of rats with 150 µg/kg b.w hull fraction of flaxseed followed by CCl4 treatment caused restoration of catalase, SOD and peroxidase by 37.70%, 108.22% and 23.89% respectively as compared to control. The group treated with 250 µg/kg b.w hull fraction of flaxseed showed the restoration of 67.30%, 152.82% and 39.88% of catalase, SOD and peroxidase, respectively. Conclusion:In conclusion, SDG fed in the form of flaxseed hull is responsible for its hepatoprotective properties. Further, it can be used as a potential source of nutraceutical agent and studies are required in this field to examine its use in large scale for food and feed industries.

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“…The antioxidant property of the SDG lignan present in flaxseed has been demonstrated [26,27]. The SDG lignan exhibits its antioxidant activity by decreasing the free oxygen radicals [28].…”

Section: Declaration Of Interestmentioning

confidence: 99%