Suppression of Oxidative Stress as a Mechanism of Reduction of Hypercholesterolemic Atherosclerosis by Cyclooxygenase Inhibitors

Lee, Paul; Prasad, Kailash

doi:10.1007/s00547-003-0976-4

Cited by 15 publications

(12 citation statements)

References 41 publications

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“…Aortic-CL levels in group II were similar to those in group I. Aortic-CL in rabbits decreases with 0.25% cholesterol 25,35 and 0.5% cholesterol diets, 5,22 and increases with a 1% cholesterol diet. 4 No change in aortic-CL in the present study could be due to the 1% cholesterol diet for 1 week in the fourth week of the protocol.…”

Section: Discussionsupporting

confidence: 60%

“…Arterial blood collected in ethylenediamine tetraacetic acid-containing tubes was used to measure WBC counts using a Technicon H6000 System (Technicon Instruments Corp, Terrytown, NY), and the WBC-CL was measured using a previously described method. 1,22 Briefly, 0.05 mL of blood was added to a tube containing Hank's balanced salt solution (HBSS), and luminol at a final concentration of 10 -4 mol/L. Samples were placed in a luminometer (AutoLumat LB953) at 37 C and phagocytosis was initiated by adding 0.1 mL (10 mg/mL stock solution) of opsonized zymosan, prepared as described previously.…”

Section: Chemiluminescent Activity Of White Blood Cellsmentioning

confidence: 99%

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Vitamin E Does Not Regress Hypercholesterolemic Atherosclerosis

Prasad

2009

J Cardiovasc Pharmacol Ther

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Section: Discussionsupporting

confidence: 60%

Section: Chemiluminescent Activity Of White Blood Cellsmentioning

confidence: 99%

Vitamin E Does Not Regress Hypercholesterolemic Atherosclerosis

Prasad

2009

J Cardiovasc Pharmacol Ther

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“…[1][2][3][4][5] Antioxidants and suppressants of sources of ROS are effective in the suppression of the development of atherosclerosis. [1][2][3][4]6,7 Flax lignan complex contains secoisolariciresinol diglucoside (SDG; 34% to 38%), cinnamic acid glucoside (15% to 21%), and hydroxymethylglutaric acid (9.6% to 11.0%). 8 SDG 9,10 and cinnamic acid 11 are antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Flax Lignan Complex Slows Down the Progression of Atherosclerosis in Hyperlipidemic Rabbits

Prasad

2009

J Cardiovasc Pharmacol Ther

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Flax lignan complex suppresses the development of hypercholesterolemic atherosclerosis. However, it is not known whether flax lignan complex would slow down the progression of hypercholesterolemic atherosclerosis. This study was carried out to determine whether flax lignan complex slows down the progression of already developed atherosclerosis, and whether this effect is associated with reductions in serum lipids and oxidative stress. The studies were conducted in 4 groups of rabbits: group I, regular diet (2 months); group II, 0.25% cholesterol diet (2 months); group III, 0.25% cholesterol diet (4 months); group IV, 0.25% cholesterol diet (2 months) followed by 0.25% cholesterol diet plus flax lignan complex (2 months). Serum lipids and oxidative stress parameters (malondialdehyde, antioxidant reserve, white blood cell chemiluminescence) were measured before and at monthly intervals thereafter on their respective diets. Aortas were removed at the end of the protocol for assessment of atherosclerosis and oxidative stress. Atherosclerosis in group II was associated with hyperlipidemia and increased oxidative stress. Significant areas of the aortic intimal surfaces from group II (37.76% + 7.96%), group III (76.6% + 9.04%), and group IV (52.95% + 10.29%) were covered with atherosclerotic plaques. Group IV rabbits had 40% more atherosclerotic lesions than group II but 31% fewer lesions than group III. The flax lignan complex-induced reduction in the progression of atherosclerosis was associated with reductions in oxidative stress. In conclusion, flax lignan complex was effective in slowing down the progression of atherosclerosis by 31%, and this effect was associated with a reduction in oxidative stress.

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“…Hypercholesterolemia induces oxidative stress, since it increases the formation of reactive oxygen species from membrane phospholipids during prostaglandin synthesis. Thus antioxidants and hypolipidemic agents suppress the development of hypercholesterolemic atherosclerosis and induce regression of atherosclerosis (Paul and Kailash, 2003). Therefore suppression of atherosclerosis is associated with decrease in oxidative stress and serum lipids (Kabiri et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic and antithrombotic evaluation of Myrtus communis L. in cholesterol-fed rabbits

Khan¹,

Feroz²,

Jamil³

et al. 2014

Afr. J. Pharm. Pharmacol.

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Herbs have been a great source of natural substances used to prevent many cardiovascular diseases (CVD). Blood lipid levels and coagulation parameters are probably the major determinant for producing CVDs. The present study was undertaken to evaluate the hypo-lipidemic and anti-thrombotic activities of aqueous extract of Myrtus communis L. fruit (AEM) in cholesterol-fed rabbits. Hyperlipidemia was induced following administration of cholesterol for 45 days. Animals of treated group were administered AEM daily for 30 and 45 days at dose of 50 mg/kg. Biochemical tests were performed at the end of dosing that is, on 31st day and again on 46th day. The administration of AEM (50 mg/kg/day) revealed reduction in serum triglycerides and low density lipoprotein; there was also an increase in thrombin and fibrinogen time. Results of present study indicate that the extract exhibited hypolipidemic effects and has also an effect on blood coagulation parameters which may be of value in CVDs. However, further studies are necessary to explore the precise mechanism of action of these effects.

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Suppression of Oxidative Stress as a Mechanism of Reduction of Hypercholesterolemic Atherosclerosis by Cyclooxygenase Inhibitors

Abstract: Hypercholesterolemia increases the formation of arachidonic acid from membrane phospholipids. Reactive oxgyen species (ROS) are generated during the synthesis of prostaglandins (PGs) from arachidonic acid. ROS have been implicated in the development of hypercholesterolemic atherosclerosis.

Cited by 15 publications

References 41 publications

Vitamin E Does Not Regress Hypercholesterolemic Atherosclerosis

Vitamin E Does Not Regress Hypercholesterolemic Atherosclerosis

Flax Lignan Complex Slows Down the Progression of Atherosclerosis in Hyperlipidemic Rabbits

Hypolipidemic and antithrombotic evaluation of Myrtus communis L. in cholesterol-fed rabbits

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