Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease

Ogborn, Malcolm R.; Nitschmann, Evan; Weiler, Hope A.; Leswick, David A.; Bankovic-Calic, Neda

doi:10.1046/j.1523-1755.1999.00287.x

Cited by 59 publications

(65 citation statements)

References 34 publications

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“…Flaxseed-supplemented diets as well as flax oil, markedly lowered the UA level in healthy rats and in the condition of renal toxicity 33,34 . Additionally, flaxseed oil or flaxseed diets have lowered the serum and kidney creatinine levels in several pathological and experimental conditions 31,32,35,36 . Flaxseed oil has been shown to inhibit the renin mRNA levels in SHR 37 .…”

Section: Discussionmentioning

confidence: 99%

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Bishri

2013

J. Oleo Sci.

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Section: Discussionmentioning

confidence: 99%

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Bishri

2013

J. Oleo Sci.

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“…Fibrosis was measured as previously described by Ogborn et al [13]. Briefly, sections were stained using aniline blue alone in an adaptation of Masson’s trichrome stain [14].…”

Section: Methodsmentioning

confidence: 99%

Increased Renal Fibrosis and Expression of Renal Phosphatidylinositol 4-Kinase-β and Phospholipase C<sub>γ1</sub> Proteins in Piglets Exposed to Ochratoxin-A

Aukema¹,

House²,

Bankovic-Calic³

et al. 2004

Nephron Physiol

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Endemic nephropathy has been linked to exposure of ochratoxin-A (OA) in grains and animal products. The underlying events surrounding this form of renal injury are not well known, partly due to the lack of a suitable animal model of the disease. Therefore, in this study, a pig model of OA-induced renal injury was established and used to examine whether elements of the phosphoinositide signalling pathway are altered in this disease. Weanling piglets were fed diets containing 0, 2, and 4 ppm OA for 6 weeks. Serum creatinine and urea and renal fibrosis were monitored biweekly using serial blood samples and renal biopsies. At termination, the protein levels of renal phosphatidylinositol 4-kinase-β (PtdIns4Kβ) and phospholipase C_γ1 (PLC_γ1) were determined using immunoblotting and scanning densitometry. Serum creatinine was elevated by 2 weeks and renal fibrosis was elevated by 4 weeks at both levels of inclusion of OA. At the end of the experimental period, kidney size and water content were elevated, as were the protein levels of renal PtdIns4Kβ and PLC_γ1 in OA-exposed animals. Therefore, serial biopsies can be used to track changes in renal pathology in the OA-exposed piglet. We conclude that this is a useful model for OA-induced renal injury in which the underlying molecular events associated with this form of renal injury can be studied.

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“…Linseed kidney protective activity is exerted through three mechanisms: moderation of associated interstitial nephritis, alteration of renal content of polyunsaturated fatty acids and less formation of inflammatory classes of renal prostanoides (Ogborn et al, 1999; BankovicCalic et al, 2002). It was concluded from the studies of Ghule et al (2011Ghule et al ( , 2012) that renal protective activity of ethanolic extract of flaxseed may result from its action on rennin-angiotensin system and inhibition of renal artery occlusion.…”

Section: Histological Analysesmentioning

confidence: 99%

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Beroual¹,

Almasi‐Hashiani²,

Bachtarzi³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: The therapeutic safety of herbal medicine is a major concern for consumers and users. After studying the effects of linseed on hair growth in rabbits, the turn is to evaluate its safety by the observation of some clinical, biological and anatomo-pathological aspects. Materials and Methods: A study was conducted during a period of three months on two groups of rabbits (control and test). Test group daily received feed supplemented with 3g of ground linseed while the control animals received the same feed without any additives. Weekly, rabbits were weighed and monthly blood samples were taken. By the end of the trial, liver and kidneys biopsies were analyzed for histological and cytological lesions. Results: There was no significant improvement in weight gain in the test group rabbits, in which biochemical parameters had differentially evolved with a decrease in their Glycemia and cholesterolemia. There were also no modifications in their serum hepatic and renal marker enzymes and their liver and kidneys exhibited noticeably normal histology without any anatomically detectable anomalies. Conclusion: These findings confirm that prolonged linseed ingestion in rabbits is safe.

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Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease

Abstract: Flaxseed ameliorates Han:SPRD-cy rat polycystic kidney disease through moderation of the associated chronic interstitial nephritis. The diet alters renal content of polyunsaturated fatty acids in a manner that may promote the formation of less inflammatory classes of renal prostanoids.

Cited by 59 publications

References 34 publications

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Increased Renal Fibrosis and Expression of Renal Phosphatidylinositol 4-Kinase-β and Phospholipase C<sub>γ1</sub> Proteins in Piglets Exposed to Ochratoxin-A

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

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