Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Bishri, Widad M. Al

doi:10.5650/jos.62.709

Cited by 22 publications

(12 citation statements)

References 32 publications

(25 reference statements)

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“…43,74.29 and 71.43,respectively (Table 6). This result exhibited a harmony with those reported by Al-Bishri (2013), who demonstrated the first time the favorable effects of a flax seed-supplemented standard diet in improving liver and kidney functions in the hypertensive condition. These effects are likely to be mediated by the alpha-linolenic acid (ALA) and linoleic acid (LA) contents of flax seed oil due to its demonstrated ability to lower the blood pressure.…”

Section: Comparison Of Treatments With Genome Template Stability (Gts)supporting

confidence: 87%

Genetical Studies of Flax Seed Effect on Liver and Spleen of Rats With Nephropathy.

Zedan

Rehan²,

Mahmoud

2015

Journal of Agricultural Chemistry and Biotechnology

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The flax seed is rich with lignans and α-linolenic acid plus antioxidant effects. The purpose of this study was to estimate the effect of flax seed on recovery of acute renal failure in rats. Twenty four rats were divided into four groups (each group has six individuals). One group was used as negative control (n=6), whereas the other three groups (n=18) injected with glycerol to induce acute renal failure. One of three groups fed on basal diet as positive control (C+), while the second and third groups (FS1 and FS2) was fed on 5 and 7% flax seeds for 28 days. In acute renal failure by glycerol in rats, kidneys, liver and heart weight was significantly increased when compared with negative control. RAPD amplifies the target genomic DNA with five primers generated a total of 116, 142 DNA fragments in liver and spleen, respectively. In liver, fifteen band of thirty eight (39.47 %) were polymorphic, whereas twenty three bands were monomorphic for all treatments. The highest level of polymorphism (55.56 %) was observed in primer 5 and the lowest level of polymorphism was 16.7% in primer 1. In spleen, total of bands resulted from five random primer was forty two bands, the polymorphic bands were sixteen (38.1 %) and the monomorphic band were twenty six bands (61.9 %).

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Section: Comparison Of Treatments With Genome Template Stability (Gts)supporting

confidence: 87%

Genetical Studies of Flax Seed Effect on Liver and Spleen of Rats With Nephropathy.

Zedan

Rehan²,

Mahmoud

2015

Journal of Agricultural Chemistry and Biotechnology

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“…The normal ALT values in the STZ-N3 group could be the result of the beneficial influence of a higher content of n3 fatty acids, mainly linolenic acid, originating from the linseed oil present in the experimental feed. Indeed, the beneficial effect of n3 fatty acids on liver and kidney function measured by ALT was previously reported by AL-BISHRI (2013). This result implies that treatment with n3 FA could ameliorate the hepatocyte damage caused by the administration of STZ.…”

Section: Discussionsupporting

confidence: 67%

Corticosterone values and blood biochemistry in a model of streptozotocin-induced diabetes: the influence of dietary n6/n3 ratio

et al. 2019

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A. DOVČ, S. ŽUŽUL, M. BENIĆ, T. MAŠEK, K. STARČEVIĆ: Corticosterone values and blood biochemistry in a model of streptozotocin-induced diabetes: the influence of dietary n6/n3 ratio. Vet. arhiv 89, 885-894, 2019. ABSTRACTThe study was carried out to investigate the influence of dietary n6/n3 ratio in streptozotocin (STZ) induced diabetes on serum biochemistry and corticosterone values in blood in 15 Wistar male rats assigned into three experimental groups, two diabetic and a control group (STZ-N3, STZ-N6, CON) fed with different diets (n6/n3 ratio: ≈ 1, n6/n3 ratio: ≈60, CON n6/n3 ratio: ≈7). Significantly higher values of alkaline phosphatase (AP) and beta-hydroxybutyrate (BHB) and lower levels for triglyceride and albumin were noticed in both STZ treated groups compared to the control. The values for blood urea nitrogen (BUN) were increased in only the STZ-N3 group compared to the control (P<0.05). The values for the total bilirubin (P<0.05) and alanine aminotransferase (ALT) (P<0.05) were higher in only the STZ-N6 group compared to the control. In addition, Vet. arhiv 89 (6), 885-894, 2019 G. Gregurić Gračner et al.: Corticosterone values and blood biochemistry in a model of streptozotocin-induced diabetes: the influence of dietary n6/n3 ratio the STZ-N3 group had lower albumin values compared to the STZ-N6 group (P < 0.001). Corticosterone values did not significantly differ among all three experimental groups indicating similar levels of stress. In conclusion, the n6/n3 ratio significantly influences blood biochemical parameters in STZ-treated rats. Nevertheless, neither the n6/n3 ratio nor blood sampling and handling influences corticosterone values, which proved the validity of the STZ-induced rodent model of diabetes mellitus in the experimental conditions described.

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“…Due to its composition, studies have related the ingestion of flaxseed with a reduction in cardiovascular risks such as lipid profile improvement, blood pressure reduction and decreased formation of atheroma plaque …”

Section: Introductionmentioning

confidence: 99%

“…As described in the literature, the difference between flaxseed flour and flaxseed oil is mainly in the amount of omega-3 present, the concentration of ALA in the oil being around 57/100 g and in the flour 23.07/100 g. In addition, flaxseed flour also includes in its composition the main lignan found in flaxseed: secoisolariciresinol diglucoside (SDG). 9 Due to its composition, studies have related the ingestion of flaxseed with a reduction in cardiovascular risks such as lipid profile improvement, 10 blood pressure reduction 11 and decreased formation of atheroma plaque. 12 In addition, studies have concluded that the administration of flaxseed during lactation improves the lipid profile of offspring in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams

et al. 2015

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Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats

Cited by 22 publications

References 32 publications

Genetical Studies of Flax Seed Effect on Liver and Spleen of Rats With Nephropathy.

Genetical Studies of Flax Seed Effect on Liver and Spleen of Rats With Nephropathy.

Corticosterone values and blood biochemistry in a model of streptozotocin-induced diabetes: the influence of dietary n6/n3 ratio

Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams

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