Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves

Üstün, Osman; Özçelık, Berrın; Akyön, Yakut; Abbasoğlu, Ufuk; Yeşilada, Erdem

doi:10.1016/j.jep.2006.06.001

Cited by 77 publications

(41 citation statements)

References 22 publications

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“…Cistus species have widespread utilization in Turkish folk medicine to cure some ailments like rheumatism, stomachache, hemorrhoids, sterility, urinary inflammations, peptic ulcer and diabetes mellitus [4,5]. Pharmacological activities including cytotoxic [6,7], antinociceptive, hepatoprotective [8,9] anti-microbial [10,11], anti-viral [12,13], anti-inflammatory [9,14,15], antioxidant [16,17], analgesic [9,18,19], spasmolytic [20][21][22], anti-ulcerogenic, gastro protective [23][24][25], and antihyperglycemic [26] activities of Cistus species have been reported. Labdane type diterpenes [7,27,28], flavonoids [9,29] flavanols and proanthocyanidins [30][31][32] were isolated from different Cistus species as active compounds.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Gürbüz¹,

Koşar²,

Güvenalp³

et al. 2018

jrp

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ABSTRACT:A rapid and simple high-performance liquid chromatography method with a Photo Diode Array (PDA) detector is developed for the simultaneous analysis of seven kaempferol, quercetin and myricetin derivatives along with an acylated flavonoid glycoside; trans-tiliroside from different Cistus species. In this study, the qualitative and quantitative analysis of the methanolic extracts of three Cistus species (C. creticus L., C. laurifolius L. and C. salviifolius L.) growing in Anatolia in terms of characterization of flavonoid compounds were performed by RP-HPLC for the first time. Trans-tiliroside, a mono-coumaroyl kaempferol glucoside was found to be the most abundant flavonoid in C. salviifolius (0.276±0.003 g/100 gextract) and C. creticus (0.253±0.001 g/100 gextract) while hyperin (0.149±0.004 g/100 gextract) and myricetin 3-O-β-galactopyranoside (0.139±0.006 g/100 gextract) were found to be the most intense flavonoids in C. laurifolius samples. The described HPLC method appears suitable for the determination of the Cistus flavonols and their glycosides and can be considered as an effective and alternative procedure for the identification and quantification of this important class of biologically active compounds.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Gürbüz¹,

Koşar²,

Güvenalp³

et al. 2018

jrp

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“…Vegetal polyphenols containing fl avonoids have antibacterial activity, as has been demonstrated in vitro by using crude plant preparations from Origanum vulgare and Cistus laurifolius. [10][11][12] However, few in vivo studies using pure fl avonoids have been published.…”

Section: Introductionmentioning

confidence: 99%

Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig

et al. 2008

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“…Previous related studies have evaluated anti-helicobacter activity of baicalein and baicalin. 11,19 We investigated the anti-H. pylori activity of chrysin, oroxylin A, wogonin including baicalein and baicalin. As reported previously, baicalin and baicalein showed bactericidal activity against H. pylori (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Evaluation of the Anti-Helicobacter pylori Activity of Scutellariae Radix

et al. 2017

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− The aim of this study was to evaluate the anti-Helicobacter pylori activity of fractions and major aglycon compounds (baicalein, chrysin, oroxylin A, wogonin) of Scutellariae Radix. Minimum inhibitory concentration (MIC) measurement, DPPH radical-scavenging assay, DNA protection assay, and urease inhibition analysis were performed. The ethyl acetate (EtOAc) fraction showed the potent anti-Helicobacter activity, and therefore, compounds in the EtOAc fraction were subjected to further assay. The MICs of chrysin, oroxylin A, and wogonin against Helicobacter pylori 26695 were 6.25, 12.5 and 25 µg/mL, respectively. Baicalein exhibited the most effective DPPH radical-scavenging activity. DNA protection using Fenton reaction, chrysin, oroxylin A, and wogonin showed effective DNA protective effect. This result was also confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). Regarding Jack bean urease (0.5 mg/mL, 50 unit/mg) inhibition, 20 mM ofbaicalein and chrysin inhibited urease activity by 88.2% and 72.5%, respectively.

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Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves

Cited by 77 publications

References 22 publications

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig

Comprehensive Evaluation of the Anti-Helicobacter pylori Activity of Scutellariae Radix

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