Flavonoids ofCrataegus Microphylla

Melikoğlu, Gülay; Bitiş, Leyla; Meriçli, Ali H.

doi:10.1080/14786410310001620673

Cited by 32 publications

(31 citation statements)

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“…Crataegus extracts were extensively tested in the last 50 years for their composition and cardiotonic activity in vitro (Ammon, 1981), especially the fruits but also the leaves (Celebi-Kocyildiz et al, 2006). More than 20 species included in the genus Crataegus from Turkey were characterized and data about their fruit composition were reported (Meriçli and Ergezen, 1994, Melikoglu et al, 1999, 2000Dönmez, 2004). Few data about the composition of leaves were reported, e.g.…”

Section: Introductionmentioning

confidence: 99%

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of Cornus mas and Crataegus monogyna, in Relation to Their Cardiotonic Potential

Badalica-Petrescu

Drăgan

Ranga

et al. 2014

Not Bot Hort Agrobot Cluj

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Our study aimed to compare the phenolic and flavonoid composition of two medicinal plants from the wild flora of Romania, traditionally known to be efficient in preventing cardiotoxicity: Cornus mas and Crataegus monogyna. As most previous studies have focused on fruits, our investigations aimed to fingerprint and quantify the two classes of compounds in aqueous leaf extracts, based on HPLC-DAD-ESI(+)MS analysis. The specific HPLC-DAD fingerprint was coupled with UV spectra at 280 and 340 nm to discriminate between three subclasses of compounds: two hydroxycinnamic acids and a flavonoid glycoside. While the C. monogyna extract contained more than 98% vitexin isomers (2'-and 4'-O-rhamnoside), the C. mas extract was very complex, containing a mixture of phenolic derivatives and flavonoid glycosides. The spectral patterns of C. mas, combined with the molecular mass and specific fragmentations allowed the identification of epi-catechin, coumaric and caffeic acids and quercetin derivatives. Based on LC-MS peak area and parallel calibrations with gallic acid and rutin, the mean concentration for flavonoids in C. mas was 13 mg/100 ml, while aprox. 65 mg/100 ml in C. monogyna extracts. Using the Folin method, the total phenol content was 105 mg/100 ml in C. mas and around three times less in the C. monogyna extract, while the antioxidant activity was increased only 1.5-1.7 times in C. mas extract compared to C. monogyna. These findings suggest a higher stability and potential of flavonoids to act as antioxidants in hydrophilic environment.

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Section: Introductionmentioning

confidence: 99%

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of Cornus mas and Crataegus monogyna, in Relation to Their Cardiotonic Potential

Badalica-Petrescu

Drăgan

Ranga

et al. 2014

Not Bot Hort Agrobot Cluj

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“…The leaves of some Turkish Crataegus species are rich in flavonoids [4,7], but the leaves of C.davisii are quiet poor and considering the results of the study, it is not probable that C. davisii can be recommended for medicinal use.…”

Section: Resultsmentioning

confidence: 99%

“…In continuation of our investigations on Turkish Crataegus species [4][5][6][7][8][9] we now investigated the constituents from the leaves of C. davisii.…”

Section: Introductionmentioning

confidence: 99%

Constituents from the leaves of Crataegus davisii Browicz

Sözer

2006

Sci Pharm

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“…The leaves of C. pinnatifida is used as a foodstuff to improve digestion, remove retention of food, promote blood circulation, and resolve blood stasis in China for a long period [1]. Several polyphenols such as chlorogenic acid, vitexin-4″-O-glucoside, vitexin-2″-Orhamnoside, vitexin, rutin, hyperoside, isoquercitrin, and quercetin have previously been isolated from leaves of C. pinnatifida [2][3][4][5]; their pharmacologic activities such as cardiac function improvement [6] and antihypertensive action [7] and their anti-inflammatory, gastroprotective, free radical scavenging, and antimicrobial activities [8] were also reported.…”

Section: Introductionmentioning

confidence: 99%

Prevention Effect in Selenite-Induced Cataract in Vivo and Antioxidative Effects in Vitro of Crataegus pinnatifida Leaves

Wang

Zhang

Zhao³

et al. 2010

Biol Trace Elem Res

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Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The present study was undertaken to evaluate the anticataract potential of Crataegus pinnatifida (hawthorn tree) leaves extract in selenite-induced cataract in vivo and antioxidant effects in vitro. In vitro antioxidant assay of C. pinnatifida leaves extract on NO production inhibition, aldose reductase inhibition, and O(2)(-) radical scavenging activities gave the IC(50) of 98.3, 89.7, and 5.98 μg/mL, respectively. To characterize some major compounds in C. pinnatifida leaves extract, nine flavonoids were identified via LC-MS/MS qualitative analysis. Based on in vitro screening results, C. pinnatifida leaves extract eye drops in 0.1% hydroxypropyl methyl cellulose solution were prepared to evaluate the anticataract potential in vivo. Administration of C. pinnatifida leaves extract eye drops alternately three times a day in rat pups with selenite-induced oxidative stress significantly increased serum SOD and CAT activities, and tended to reduce MDA level compared with control group. The antioxidant enzyme SOD, CAT, and GSH activities in lens showed a significant increase. These results may be applied in the future for the prevention and treatment of cataracts.

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Flavonoids ofCrataegus Microphylla

Cited by 32 publications

References 1 publication

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of <i>Cornus mas<i> and <i>Crataegus monogyna</i>, in Relation to Their Cardiotonic Potential

Comparative HPLC-DAD-ESI(+)MS Fingerprint and Quantification of Phenolic and Flavonoid Composition of Aqueous Leaf Extracts of <i>Cornus mas<i> and <i>Crataegus monogyna</i>, in Relation to Their Cardiotonic Potential

Constituents from the leaves of Crataegus davisii Browicz

Prevention Effect in Selenite-Induced Cataract in Vivo and Antioxidative Effects in Vitro of Crataegus pinnatifida Leaves

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