Flavonoids of<i>Artocarpus heterophyllus</i>Lam. heartwood inhibit the innate immune responses of human phagocytes

Septama, Abdi Wira; Jantan, Ibrahim; Panichayupakaranant, Pharkphoom

doi:10.1111/jphp.12952

Cited by 22 publications

(9 citation statements)

References 42 publications

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“…In India, it is also called “Panasa”, “Atibruhatphala”, “Kantaphal”, and “Kanthal” due to its physical characteristics. The AH tree is also considered to be a source of flavonoids, sterols, volatile acids, carotenoids, and tannins, which vary depending on the stage of maturity [ 6 , 7 , 8 , 9 , 10 ]. Moreover, it also has a unique combination of iron, vitamin C, vitamin B complex (especially vitamin B 6 , niacin, folic acid, and riboflavin), and minerals (mainly calcium and potassium) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Gupta

Rather

Jha

et al. 2020

Plants

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Artocarpus heterophyllus Lam. (AH) and Artocarpus lakoocha Roxb. (AL) are two endemic plants that grow on the Asian continent. To date, their applications have been aimed at using their fruit as a food source or for some of their therapeutic virtues. In this study, attention was given to the flowers of AH and AL. Initially, the cytotoxicity of the phytoextracts was assessed, and the content of minerals, phenols, and flavonoids was determined. Furthermore, some antioxidant components were identified by HPLC. Furthermore, the ability of AH and AL extracts to modulate the gene expression of some targets involved in the antioxidant response was studied. The results obtained highlighted the nutritional and antioxidant value of the AH and AL flower extracts. This study will contribute to enhancing the use of AH and AL flowers as potential supplements in human nutrition.

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Section: Introductionmentioning

confidence: 99%

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Gupta

Rather

Jha

et al. 2020

Plants

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“…20 Phagocytosis is a fundamental function of immune cells to eliminate foreign materials including pathogens. 21 In order to know correlation between NO secretion and phagocytosis, then we also observed the phagocytosis activity of treated RAW 264.7 cells using phagocytosis assay. The results showed that some of RAW 264.7 cells with LPS, β glucan and seaweed extracts treatment performed suspected-giant cells formation as a results of phagocytosis activity.…”

Section: Discussionmentioning

confidence: 99%

In vitro Immunomodulatory Effect from Edible Green Seaweed of Caulerpa lentillifera Extracts on Nitric Oxide Production and Phagocytosis Activity of RAW 264.7 Murine Macrophage Cells

Fajriah¹,

Handayani²,

Sinurat³

et al. 2020

JYP

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“…Multiagent treatment of osteosarcoma is associated with acute long-term toxicities, including potential Evidence suggests that artocarpin, a prenylated flavonoid isolated from an agricultural Artocarpus plant, has multiple pharmacological properties (e.g., anti-inflammatory, antioxidant, antibacterial, and anticancer properties). For example, artocarpin demonstrated potent anti-inflammatory effects at different stages of phagocytosis and was able to suppress human phagocyte response (Septama, Jantan, & Panichayupakaranant, 2018). In addition, studies have indicated that artocarpin possesses anticancer effects through various mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species

Lee

Ching

Chang

et al. 2018

Journal Cellular Physiology

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Osteosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. However, because of side effects and drug resistance in chemotherapy and the insufficiency of an effective adjuvant therapy for osteosarcoma, it is necessary to research novel treatments. This study was the first to investigate the anticancer effects of the flavonoid derivative artocarpin in osteosarcoma. Artocarpin induced cell apoptosis in three human osteosarcoma cell lines—U2OS, MG63, and HOS. Artocarpin was also associated with increased intracellular reactive oxygen species (ROS). Mitochondrial dysfunction was followed by the release of cytochrome c from mitochondria and accompanied by decreased antiapoptotic Bcl‐2 and Bcl‐xL and increased proapoptotic protein Bak and Bax. Artocarpin triggered endoplasmic reticulum (ER) stress, as indicated by changes in cytosol calcium levels and increased glucose‐regulated protein 78 and 94 expressions, and also increased calpains expression and activity. Animal studies revealed a dramatic 40% reduction in tumor volume after 18 days of treatment. This study demonstrated a novel anticancer activity of artocarpin against human osteosarcoma cells and in murine tumor models. In summary, artocarpin significantly induced cell apoptosis through ROS, ER stress, mitochondria, and the caspase pathway, and may thus be a novel anticancer treatment for osteosarcoma.

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Flavonoids ofArtocarpus heterophyllusLam. heartwood inhibit the innate immune responses of human phagocytes

Abstract: Artocarpanone and artocarpin were able to suppress strongly the phagocytosis of human phagocytes at different steps and have potential to be developed into potent anti-inflammatory agents.

Cited by 22 publications

References 42 publications

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

Artocarpus lakoocha Roxb. and Artocarpus heterophyllus Lam. Flowers: New Sources of Bioactive Compounds

In vitro Immunomodulatory Effect from Edible Green Seaweed of Caulerpa lentillifera Extracts on Nitric Oxide Production and Phagocytosis Activity of RAW 264.7 Murine Macrophage Cells

Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species

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