Flavonoids fromCirsium rhinoceros

Lee, Hwan Bae; Kwak, Jong Hwan; Zee, Ok Pyo; Yoo, Seung Jo

doi:10.1007/bf02980460

Cited by 20 publications

(8 citation statements)

References 7 publications

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“…In addition, compound 12 showed glucuronic acid signals (δ 72.2, 73.1, 73.9, 76.7, 99.7, 172.7) in the 13 C-NMR spectrum, and the 1 H-NMR spectrum of 12 revealed the presence of a methoxy (δ 3.82) and an anomeric proton (δ 5.07, d, J = 7.2 Hz) for a sugar moiety. Therefore, compounds 2 and 12 were identified as luteolin and chrysoeriol 7-glucuronide, respectively (Lee et al, 1994;Wagner et al, 1972;Fujii et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

et al. 2009

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Eight iridoid glycosides and four phenolic compounds were isolated from the EtOAc soluble fraction of Veronica peregrina MeOH extract as the radical scavengers for antioxidant activity. The compounds were identified as protocatechuic acid (1), luteolin (2), veronicoside (3), minecoside (4), specioside (5), amphicoside (6), catalposide (7), 6-O-cis-p-coumaroyl catalpol (8), p-hydroxy benzoic acid methyl ester (9), verproside (10), verminoside (11), and chrysoeriol 7-glucuronide (12) by spectroscopic analysis. All compounds except for 1 and 2 were isolated for the first time from this plant. The antioxidant activity was evaluated by the ORAC(Oxygen Radical Absorbance Capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2'-azobis (2-methoxypropion-amidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent. Compounds 2, 4, 5, 6, 8, and 12 exhibited potent antioxidant activity, and compounds 1, 11 had similar activity with trolox, whereas the other compounds showed weaker activity than trolox.

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Section: Resultsmentioning

confidence: 99%

Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

et al. 2009

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“…Compounds 2, 4, and 8-11 were identified by comparison of their spectral data with those published in the literature as scopoletin (Herz et al, 1970), kaempferol (Hong et al, 2008), luteolin (Lee et al, 1994), quercetin (Hong et al, 2008), apigenin (Lee et al, 1994), and chrysoeriol (Jung et al, 2001), respectively.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic phenolic compounds from Chionanthus retusus

et al. 2009

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Cytotoxicity-guided fractionation and purification of MeOH extract from Chionanthus retusus Lindl. et Paxton resulted in the isolation of compounds. Fourteen phenolic compounds were isolated from the EtOAc soluble fraction, and their structures were determined by spectroscopic analysis. Isolated compounds were identified as phillygenin (1), scopoletin (2), pinoresinol (3), kaempferol (4), aromadendrin (5), 2-(4-hydroxyphenyl)ethanol (6), 3,3',5,5',7-pentahydroxyflavanone (7), luteolin (8), quercetin (9), apigenin (10), chrysoeriol (11), phillyrin (12), oleuropein (13), (7R,8R)-guaiacylglycerol (14). All compounds except for 12 and 13 were isolated for the first time from this plant and genus Chionanthus. Anti-proliferative effect of isolated compounds were evaluated by the sulforhodamin B assay against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 4 and 8-10 were significantly active with ED50 values of 1.84-6.35 microg/mL. Also, compounds 1, 3, 5 and 7 revealed cytotoxic effects at concentrations below 30 microg/mL.

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“…Silymarin is an antioxidant component which results in enhancement of cellular antioxidant defense machinery thus increasing the antioxidant potential of cells as well as protection of the liver from toxic substance (Mourelle et al, 1989;Letteron et al, 1990;Mereish et al, 1991;Luper, 1998;Bhatia et al, 1999). A great heal of research has been conducted regarding the flavonoids harbored by thistles, and a variety of activities were exhibited by these species such as cytotoxic, antimicrobial activities as well as anti-haemorrhagic, antihypertensive, anti-hepatitis, and liver-enzyme-activating effects (Ishida et al, 1987;Lee et al, 1994Park et al, 1995Park et al, , 1997Park et al, , 2004Pezer et al, 2001;Nazaruk et al, 2005;Liu et al, 2006).…”

Section: Introductionmentioning

confidence: 97%

Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography

et al. 2011

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In order to facilitate the quality control of some selected Korean thistles (Cirsii Herb), Cirsium japonicum var ussuriense, C. japonium var spinosissimum, C. setidens, C. pendulum, C. nipponicum, Carduus crispus, and Breea segetum, a simple, accurate and reliable high performance liguid chromatography method was developed for the simultaneous determination of the six flavonoids: luteolin 5-O-glucoside (1), luteolin 7-O-glucoside (2), hispidulin 7-O-neohesperidoside (3), luteolin (4), pectolinarin (5), and apigenin (6), which were selected as the chemical markers of the thistles. Separation was achieved on an Agilent Eclipse XDB-C18 column with a gradient solvent system of 0.1% trifluoroacetic acid aqueous-methanol at a flow-rate of 1.0 mL/min and detected at 254 nm. All six calibration curves showed good linearity (R(2) > 0.991). The method was reproducible with intra- and inter-day variations of less than 6%. The recoveries were in the range of 90.01-100.05%. This analysis method was successfully utilized to quantify the six flavonoids in the 22 batches of the thistles. The results demonstrated that this method is simple, reliable and suitable for the quality control of this medicinal herb.

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Flavonoids fromCirsium rhinoceros

Cited by 20 publications

References 7 publications

Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

Cytotoxic phenolic compounds from Chionanthus retusus

Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography

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