Flavonoids from Tilia americana with anxiolytic activity in plus-maze test

Herrera-Ruíz, Maribel; Román-Ramos, Rubén; Zamilpa, Alejandro; Tortoriello, Jaime; Jiménez-Ferrer, Enrique

doi:10.1016/j.jep.2008.04.019

Cited by 84 publications

(70 citation statements)

References 17 publications

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“…mexicana collected from three different regions of Mexico produce anxiolytic and sedative-like effect equivalent to those of Tilia species previously reported and thus underline the medicinal properties accredited to the genus. 7,14,17,18 Moreover, no difference in the tranquilizing activity was found between Tilia leaves and inflorescences. These findings reinforce the medicinal properties mentioned for Tilia and provide evidence that leaves can also be used for therapeutic purposes.…”

Section: Discussionmentioning

confidence: 87%

“…7,9,17 In a preliminary study, quercetin was not detected in samples from Guerrero, Hidalgo and Veracruz, and rutin was absent in samples from Hidalgo. 7 Quercitrin, astragalin and kaempferol, previously reported in samples from other regions of Mexico, 7,17 were not detected in any of the studied samples. Our results are in agreement in that the presence of flavonoids differs depending also on the part of the plant and on the region of collection.…”

Section: Discussionmentioning

confidence: 92%

“…Previous studies reported that inflorescences of T. americana var. mexicana collected in different regions of Mexico such as Michoacan, 6 Estado de Mexico, 17 Guerrero, Hidalgo and Veracruz 7 produce anxiolytic and sedative-like effects on mice. These investigations agree with others from Latin American (T. tomentosa) and European (T. platyphyllos, T. rubra and T. argentea) species of Tilia 9,18,22 corroborating such therapeutic property of flowers and bracts.…”

Section: Discussionmentioning

confidence: 99%

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Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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“…The flavones chrysin and apigenin, obtained from medicinal plants, have shown an anxiolytic effect in rodents exposed to behavioral tests. Apparently, these compounds modulate the γ-aminobutyric acid (GABA) ergic system to produce the biological effect (Herrera-Ruiz et al, 2008). However, only a low content of flavonoids was found in this hydroethanolic extract.…”

Section: Correlation Among Anxiolytic Activity and Chemical Constituentsmentioning

confidence: 84%

Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic

Negri¹,

Santi²,

Tabach³

2010

Rev. bras. farmacogn.

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RESUMO:Humulus lupulus L., Cannabaceae, é usada como sedativo e ansiolítico na medicina popular. O método de HPLC-DAD-ESI-MS n representa uma ferramenta poderosa para a análise de produtos naturais, desde que ela fornece o espectro de UV e informações estruturais sobre os constituintes da mistura. O objetivo deste trabalho foi o de caracterizar os constituintes encontrados no extrato hidroalcoólico. Os constituintes 1-9 foram tentativamente caracterizados através do UV/DAD e ionização por electrospray (MS/MS) depois da separação usando fase reversa, tempo de retenção e dados da literatura. Os principais compostos fenólicos (baseados na área dos picos) foram caracterizados como ácido hulupínico (9), coulupona (8), dois alfaácidos amargos oxidados (principais constituintes), um deles sendo um derivado da coumulinona oxidada (5) e o outro um derivado da humulinona oxidada (7), junto com uma procianidina B (3) e os flavonoides rutina (4) e o canferol-7-O-rutinosídeo (6). Esta planta conhecida devido às suas propriedades ansiolíticas e por ser um componente da cerveja, mostrou derivados oxidados de alfa-ácidos, como principais constituintes do extrato hidroalcoólico. Unitermos: Humulus lupulus, flavonoides glicosídeos, derivados de alfa-ácidos amargos oxidados, HPLC/DAD/MS/MS.ABSTRACT: Humulus lupulus L., Cannabaceae, is commonly used as light sedative and anxiolytics in folk medicine. HPLC-DAD-ESI-MS n represents a powerful tool for the analysis of natural products, since it can simultaneously provide a UV chromatogram and significant structural information about compounds in complex mixture. The aim of this work was characterize the constituents present in hydroethanolic extract. Compounds 1-9 were tentatively characterized on the basis of UV, MS/MS, after reversed phase separation, retention time and literature data. The main phenolic compounds (based on peak area) were characterized as hulupinic acid (9), cohulupone (8), two oxidized hop alfa-bitter acids (principal constituents), one being a oxidized cohumulinone (5) and the other an oxidized humulinone (7) derivatives, together with a procyanidin dimer B (3), flavonoids rutin (4) and kaempferol-7-O-rutinoside (6). This plant known, due to anxiolytic property and beer flavoring, showed oxidized hop bitter acids, as principal constituents, in its hydroethanolic extract.

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“…Flavonoids have been shown to have effects on rodent behavior with anxiolytic potency comparable to that of typical BDZ agents. Beside this, unlike BDZ, the flavonoid anxiolytics did not induce sedation concurrent with their anti-anxiety activity (Herrera-Ruiz et al, 2008). Flavonoids glycosides, have been shown to exert CNS mediated activities, particularly as sedative-hypnotics, analgesics and anxiolytic (de Castro et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

Giorgetti¹,

Negri²

2011

Rev. bras. farmacogn.

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Abstract:In the beginning of the 19 th century, the first Brazilian scientific knowledge journal on medicinal plants the Gazetas Médicas was launch reporting Brazilian medicinal plants belonging to several botanical families. The aim of this study was research the Solanaceae species that were described as anxiolytics in the 19 th century's Brazilian Medical Gazettes and to make a revision about these species in literature. A taxonomic update, together a careful research about ethnopharmacological, pharmacological and phytochemical, patent process and reports of phytomedicines, was carried out for these Solanaceae species. In this research were found thirteen plants, but the taxonomic update reduced this number to six species. Among them, Physalis angulata L. and Solanum nigrum L. were studied and showed depressor activity on central nervous system (CNS) as described in Gazetas Médicas. This research showed that Solanaceae species reported in this study has potential as anxiolytic drugs and should be investigated more deeply.

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Flavonoids from Tilia americana with anxiolytic activity in plus-maze test

Cited by 84 publications

References 17 publications

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

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