Flavonoids from Physalis minima

Ser, Ng Ang

doi:10.1016/0031-9422(88)80810-0

Cited by 15 publications

(3 citation statements)

References 8 publications

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“…Other studies reported that aerial parts of P. minima contain withaferin A, withanolide A, stigmasterol, sitosterol, withanone, dihydroxyphysalin B2-4, isophysalin B, withaminimin, 3-O-gylcoside of kaempferol and quercetin, and phygrin [126,[128][129][130]. Another study reported the isolation of flavonoid compounds, namely, 5-methoxy-6,7-methylenedioxyflavone and 5,6,7-trimethoxyflavone [131].…”

Section: Phytochemistrymentioning

confidence: 99%

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia

Indradi

Muhaimin

Barliana

et al. 2023

Plants

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Resistance to antimalarial medicine remains a threat to the global effort for malaria eradication. The World Health Organization recently reported that artemisinin partial resistance, which was defined as delayed parasite clearance, was detected in Southeast Asia, particularly in the Greater Mekong subregion, and in Africa, particularly in Rwanda and Uganda. Therefore, the discovery of a potential new drug is important to overcome emerging drug resistance. Natural products have played an important role in drug development over the centuries, including the development of antimalarial drugs, with most of it influenced by traditional use. Recent research on traditional medicine used as an antimalarial treatment on Papua Island, Indonesia, reported that 72 plant species have been used as traditional medicine, with Alstonia scholaris, Carica papaya, Andrographis paniculata, and Physalis minima as the most frequently used medicinal plants. This review aimed to highlight the current research status of these plants for potential novel antiplasmodial development. In conclusion, A. paniculata has the highest potential to be developed as an antiplasmodial, and its extract and known bioactive isolate andrographolide posed strong activity both in vitro and in vivo. A. scholaris and C. papaya also have the potential to be further investigated as both have good potential for their antiplasmodial activities in vivo. However, P. minima is a less studied medicinal plant; nevertheless, it opens the opportunity to explore the potential of this plant.

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Section: Phytochemistrymentioning

confidence: 99%

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia

Indradi

Muhaimin

Barliana

et al. 2023

Plants

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“…angulata leaf water extract has a high antioxidant effect in vitro [12,16]. This might be due to the flavonoid content of P. angulata which are 5-Methoxy-6,7-methylenedioxyflavone and 5,6,7-trimethoxyflavone [56]. Flavonoids prevent tissue damage from free radicals through various mechanisms.…”

Section: Febianti Et Almentioning

confidence: 99%

Vasoprotective Effect of Physalis Angulata L. Leaf Water Extract on Kidney of Nω-Nitro-L-Arginine Methyl Ester-Induced Endothelial Dysfunction Rat Model

Febianti

Permatasari

Soeharto

2019

Asian J Pharm Clin Res

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Objective: This study was to investigate the effect of Physalis angulata L. leaf water extract on vascular rarefaction, oxidative stress, and inflammation on the kidney of Nω-nitro-L-arginine methyl ester (L-NAME)-induced male Wistar rats.Methods: A total of 25 male Wistar rats were divided into five equal groups (normal control: 40 mg/kg/day of normal saline; L-NAME group; and treatments I, II, and III: L-NAME plus P. angulata L. leaf water extract doses 500 mg/kg/day, 1500 mg/kg/day, and 2500 mg/kg/day, respectively). Endothelial dysfunction was induced by 40 mg/kg/day L-NAME intraperitoneally. The treatment lasts for 15 days. Vascular rarefaction was indicated by the decrease in vascular density, which considered as vascular number per high-power field in hematoxylin-eosin staining preparation. Kidney oxidative stress test was performed by measuring malondialdehyde (MDA) level with thiobarbituric acid reactive substances assay. The inflammatory marker was the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) expression which examined using an immunohistochemical method with an antibody against p65.Results: At the dose of 500 mg/kg/day and 1500 mg/kg/day, P. angulata leaf water extract supplementation increased the vascular density, decreased the MDA level, and decreased the NF-κB expression compared to the L-NAME group.Conclusion: The administration of P. angulata L. leaf water extract in particular concentration has a vasoprotective effect by preventing kidney vascular rarefaction, oxidative stress, and inflammation on L-NAME-induced male Wistar rat.

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“…This plant could be used as traditional Chinese medicine for treatment of prostatitis, tussis, pharyngalgia, dysentery, difficulty in micturition and jaundice [2]. Numerous bioactive components, such as steroids (physalins, neophysalin and withanolides) [3][4][5][6][7][8], sesquiterpenes and norsesquiterpenes [9,10], flavonoids [11,12] and alkaloids [13] were isolated from this genus, and some of which showed considerable anti-cancer [14,15], anti-inflammatory [16], inhibit diabetes [17], antioxidant [18], and antimicrobial activities [19]. Anti-inflammatory active constituents from this genus have been reported and caught our attention.…”

Section: Introductionmentioning

confidence: 99%

New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii

Zhang

Zhou

Li³

et al. 2020

Fitoterapia

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Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC 50 values of 3.22 ± 0.25, 6.35 ± 0.84, and 11.13 ± 1.47 μM, respectively. Optical rotation was acquired in CHCl 3 on Jasco P-1020 polarimeter at room temperature. UV (Ultraviolet) spectra were recorded on V-550 UV/vis spectrophotometer. IR (Infrared) spectra were determined by a

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Flavonoids from Physalis minima

Cited by 15 publications

References 8 publications

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia

Vasoprotective Effect of Physalis Angulata L. Leaf Water Extract on Kidney of Nω-Nitro-L-Arginine Methyl Ester-Induced Endothelial Dysfunction Rat Model

New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii

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