Flavonoids from Dracocephalum moldavica

Ayaz, Sultan; Bahang,; Aisa, Haji Akber; Éshbakova, K. A.

doi:10.1007/s10600-008-9065-4

Cited by 48 publications

(27 citation statements)

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“…In the literature, there are also reports on the presence of additional phenolic compounds in D. moldavica plants, which, besides RA, can be responsible for the observed antioxidant activity. These include caffeic acid, chlorogenic acid (Kakasy et al 2006), phenylpropanoids and flavonoids (Sultan et al 2008). To identify the compounds in hairy roots of D. moldavica, further phytochemical analyses are needed.…”

Section: Resultsmentioning

confidence: 99%

“…D. moldavica is frequently used as a food ingredient and a carditonic agent, as well as for the treatment of stomach and liver disorders, and headache (Dastmalchi et al 2007a, b). There are also reports on anti-Helicobacter pylori activity (Ghanndi et al 2004) as well as sedative, analgesic and wound-healing properties of dragonhead extracts (Sultan et al 2008). Crude extracts of the aerial parts of D. moldavica contain a number of constituents with well-documented biological activity, including flavonoids (luteolin, 7-O-glucoside luteolin, apigenin), iridoids, essential oil components, ursolic and oleanolic acids as well as hydroxycinnamic acids with caffeic, ferulic and rosmarinic acids (Kakasy et al 2006;Popova et al 2008;Sultan et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential

et al. 2013

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Hairy roots of Dracocephalum moldavica L. were induced using Agrobacterium rhizogenes strain A4. Transformed roots were obtained from shoot explants with low transformation frequency of up to 3 %. The effects of different liquid media: Murashige and Skoog (MS), Gamborg et al. (B5) and Woody Plant (WP) with full-and half-strength ( MS, B5, WP), on biomass accumulation and rosmarinic acid (RA) content were investigated. The hairy roots were cultured in photoperiod (16 h light/8 h dark) and darkness. Biomass of D. moldavica hairy roots was the highest (7.23 g flask -1 of fresh weight and 0.89 g flask -1 of dry weight) in the cultures grown in WP medium under periodic light. Ultra performance liquid chromatography analysis revealed the highest RA content (78 mg g -1 dry wt) in roots cultured in B5 medium under photoperiod conditions. It was about tenfold higher compared to roots of field-grown mother plants. Antioxidant activities and total phenolic contents of methanolic extracts of D. moldavica hairy roots cultured in B5 and WP media under photoperiod and darkness and roots of field grown plants were compared. All extracts were investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging and phosphomolybdenum reduction assays. Total phenolic contents were estimated by the FolinCiocalteu method. The methanolic extract of D. moldavica hairy roots grown in B5 medium under photoperiod possessed the strongest effects on reducing Mo and DPPH radical scavenging. The activities were significantly higher (p B 0.05) than those of methanolic extract of roots of intact plants grown in the field. The most active methanolic extract of hairy roots was characterized by the highest level of rosmarinic acid and total content of phenolic compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential

et al. 2013

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“…Its aerial parts have been widely utilized in traditional medicine for the treatment of stomach and liver disorders as well as headache and toothache (Dastmalchi et al, 2007). Studies indicate that D. moldavica extracts have anti-Helicobacter pylori activity (Ghannadi et al, 2004) as well as sedative, analgesic and wound-healing properties (Sultan et al, 2008). The main substances responsible for the therapeutic effects of the D. moldavica aerial parts are phenolic acids (mainly rosmarinic, caffeic and ferulic acids), flavonoids and essential oil components (Kakasy et al, 2006;Popova et al, 2008;Sultan et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Studies indicate that D. moldavica extracts have anti-Helicobacter pylori activity (Ghannadi et al, 2004) as well as sedative, analgesic and wound-healing properties (Sultan et al, 2008). The main substances responsible for the therapeutic effects of the D. moldavica aerial parts are phenolic acids (mainly rosmarinic, caffeic and ferulic acids), flavonoids and essential oil components (Kakasy et al, 2006;Popova et al, 2008;Sultan et al, 2008). Flavonoids and phenolic acids are known to be beneficial to human health and disease prevention thanks to their strong antioxidant activity, capacity to scavenge free radicals and ability to neutralize reactive oxygen species (Saxena et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid Accumulation and Antioxidant Potential of Dracocephalum moldavica L. Cell Suspension Culture

Weremczuk-Jeżyna

Grzegorczyk-Karolak

Frydrych

et al. 2017

Not Bot Horti Agrobo

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Dracocephalum moldavica L. (Lamiaceae) is known for its medicinal properties; however greater yields can potentially be achieved by in vitro cultivation. A cell suspension culture of D. moldavica L. (Lamiaceae) derived from root-derived callus was established in liquid MS medium supplemented with 2,4-D 0.5 mg/l and BAP 0.2 mg/l. The biomass and rosmarinic acid (RA) content were analyzed during the 15-day growth cycle of the culture. The highest fresh and dry weight (14.29 g/flask and 1.14 g/flask, respectively) and RA level (27.2 mg/g DW) were reached at day 12 of culture. Methanolic extracts of the culture were assayed for total phenolic content using the Folin-Ciocalteau method, and antioxidant activities using three in vitro tests: ABTS radical scavenging, ferric ion reduction (FRAP) and lipid peroxidation (LPO). RA content and antioxidant potential were found to be higher in cell suspension culture than in root-derived callus. The cell suspension culture also exhibited higher concentrations of RA and ABTS radical scavenging activity than those of the aerial parts of six-month-old field-grown plants of D. moldavica. The overall results show a significant correlation between antioxidant activity, total phenolic content and RA content of the examined extracts. The study presents for the first time the use of cell cultures of D. moldavica for production of therapeutically-valuable metabolites. Our results suggest that the obtained culture could be considered as a potential source of rosmarinic acid, a compound known for its strong antioxidant activity.

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“…There are two common forms of dragonhead, with white and blue flowers, differing mainly in their flowering period. It flowers mainly in July and sets fruit in August, and contains flavones, terpenes, proteins, polypeptides and 16 amino acids, of which 8 are essential (Sultan et al, 2008). It is frequently consumed as food and drug additives.…”

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Physicochemical and grinding characteristics of dragonhead seeds

Dziki¹,

Miś²,

Gładyszewska³

et al. 2013

International Agrophysics

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A b s t r a c t. The results of investigations on the physicochemical and grinding characteristics of Moldavian dragonhead seeds are presented. The data obtained showed that the physical properties (average size, sphericity, surface area, 1 000 seed mass, dynamic angle of repose, coefficient of static friction, and bulk and true densities) of the white and blue form of dragonhead seeds were not significantly different. Both forms of dragonhead showed similar levels of protein (average of 21%), whereas the blue form of dragonhead had a lower fat content (average of 23.1%) and higher mucilage content (13.35%) in comparison to the blue form of seed (24.6 and 9.95%, respectively). Antioxidant capacity of dragonhead seeds was comparable for both forms and averaged about 40%, which corresponded to EC50 values of 0.12 and 0.13 mg ml -1 for the white and blue forms, respectively. The grinding material showed similar particle size distribution of ground material for both forms of dragonhead seeds. The lowest values of specific grinding energy were obtained for the white form of dragonhead seeds, those for the blue form were significantly higher. Grinding of dragonhead seeds using a screen 2.0 mm mesh size caused screen hole clogging. This problem did not occur when dragonhead seeds were mixed with wheat grain.K e y w o r d s: dragonhead, seed, physicochemical properties, grinding INTRODUCTIONThe plant Dracocephalum moldavica L. commonly known as Moldavian balm or Moldavian dragonhead is a perennial herb belonging to the Lamiaceae (Labiatae) family. It is native to central Asia and is naturalized in eastern and central Europe (Dastmalchi et al., 2007;Said-Al-Ahl and Abdou, 2009). It is also an introduced plant to the northeastern United States. There are two common forms of dragonhead, with white and blue flowers, differing mainly in their flowering period. It flowers mainly in July and sets fruit in August, and contains flavones, terpenes, proteins, polypeptides and 16 amino acids, of which 8 are essential (Sultan et al., 2008). It is frequently consumed as food and drug additives. Dragonhead seed yield is about 1 600 and 1 900 kg ha -1 for the white and blue form, respectively (Hanczakowski et al., 2009). Seeds are rich in fatty oil, whose content ranges from 18 to 29%. This oil is rich in unsaturated fatty acids (about 90%), principally the linolenic and linoleic acids (about 60 and 20%, respectively) which belong to essential fatty acids (Domokos et al., 1994). Apart from this, dragonhead seeds (DHS) contain about 21% of protein with beneficial amino acid composition and high biological value (Hanczakowski et al., 2009). DHS are an excellent source of mucilage with the soluble fraction of dietary fibres. These interesting properties categorise DHS into the group of raw materials suitable for nutraceuticals, food supplements, and functional food applications. However, information on its use in the food industry is rather scarce, possibly due to its limited application and lack of thorough scientific knowledge in this a...

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Flavonoids from Dracocephalum moldavica

Cited by 48 publications

References 3 publications

Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential

Hairy roots of Dracocephalum moldavica: rosmarinic acid content and antioxidant potential

Rosmarinic Acid Accumulation and Antioxidant Potential of Dracocephalum moldavica L. Cell Suspension Culture

Physicochemical and grinding characteristics of dragonhead seeds

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