Flavonoid Glycosides of Polygonum capitatum Protect against Inflammation Associated with Helicobacter pylori Infection

Abstract

The antibacterial and anti-inflammatory activities, and protective effects of extracts (flavonoid glycosides) of Polygonum capitatum were investigated to detect the evidence for the utilization of the herb in the clinical therapy of gastritis caused by H. pylori. A mouse gastritis model was established using H. pylori. According to treating methods, model mice were random assigned into a model group (MG group), a triple antibiotics group (TG group, clarithromycin, omeprazole and amoxicillin), low/middle/high concentrations of flavonoid glycosides groups (LF, MF and HF groups) and low/middle/high concentrations of flavonoid glycosides and amoxicillin groups (LFA, MFA and HFA groups). A group with pathogen-free mice was regarded as a control group (CG group). The eradicate rates of H. pylori were 100%, 93%, 89% in TG, MFA and HF groups. The serum levels of IFN-gamma and gastrin were higher in a MG group than those from all other groups (P < 0.05). The serum levels of IFN-gamma and gastrin were reduced significantly in LF, MF and HF groups (P < 0.05) while little changes were observed in LFA, MFA and HFA groups. In contrast, the serum levels of IL-4 were lower and higher in MG and CG groups compared with other groups (P<0.05). The serum levels of IL-4 were increased significantly in LF, MF and HF groups (P < 0.05) while little changes were found in LFA, MFA and HFA groups. According to pathological scores, flavonoid glycosides therapy showed better protection for gastric injuries than the combination of flavonoid glycoside and amoxicillin (P < 0.05). The results suggested that flavonoid glycoside has repairing functions for gastric injuries. The results suggest that the plant can treat gastritis and protect against gastric injuries. The flavonoid glycosides from Polygonum capitatum should be developed as a potential drug for the therapy of gastritis caused by H. pylori.

Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach

“…Acacetin and rosmarinic acid were the major components of A. rugosa [ 11 , 45 ] and were associated with eight and four gastritis-related genes, respectively. Acacetin, calycosin, diosmetin, and luteolin were classified as flavonoids, which are known to have protective effects against inflammation [ 46 ]. Flavonoid-rich fractions showed greater anti-gastritis activity than anti-ulcer drugs through modulation of the NF-κB signaling pathway in stomach tissues in gastritis-induced mice [ 47 ].…”

Effects of curcumin on Helicobacter pylori infection

“…Serum levels of IFN-γ, IL-4, gastrin, and somatostatin were determined using an ELISA assay as described by Zhang et al (20). Anti-IFN-γ and IL-4 Quantikine ELISA kits were purchased from B&D Systems (Minneapolis, MN, USA), anti-somatostatin ELISA kit was purchased from LSBio (Seattle, WA, USA), and anti-gastrin ELISA kit from Sigma.…”

A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine

“…e results showed that Wei Bi Mei granules is effective and safe in the treatment of H. pylori infection, and further evaluation regarding its anti-H. pylori activity is warranted. Tinospora [36][37][38]. ese observations not only indicated the direct anti-H. pylori activity of TCM but also highlighted its potential effects in the treatment of H. pylori-associated GPL.…”