Effects of curcumin on Helicobacter pylori infection

Abstract

Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on Helicobacter pylori (H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pylori antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration.In addition, we evaluated the effects on biofilm production and antibacterial antibody response.Results: In all tests, one sample (Sabinsa) was consistently the most active.Conclusions: All curcumin samples showed some anti-H. pylori effects, but only some of the tested samples had significant activity.

Influence of N‐acylhomoserine lactonase silver nanoparticles on the quorum sensing system of Helicobacter pylori: A potential strategy to combat biofilm formation

“…Currently, different control strategies were examined to inhibit the biofilm formation to lower the recurrent H. pylori infections [39,40]. In the present investigation, we have showed that H. pylori can be controlled effectively by exposure to AiiA‐AgNPs.…”

Survival and Control of Campylobacter in Poultry Production Environment

“…To the best of our knowledge, the specific antimicrobial mechanism of curcumin against Campylobacter has not been investigated. The effect of curcumin against Helicobacter pylori, a highly relevant bacterium to Campylobacter, has been repeatedly confirmed in several studies (Di Mario et al, 2007;Zaidi et al, 2009;Sarkar et al, 2016;Vetvicka et al, 2016). One study of using a high-throughput screening of 5,000 chemical compounds discovered that the inhibition of H. pylori by curcumin was due to the inhibition of shikimate pathway (Han et al, 2006).…”

Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

“…Both pro-inflammatory NF-κB and the motogenic response in H. pylori -infected epithelial cells were inhibited by curcumin [60]. In recent trials, the addition of curcumin to triple therapy regimes ameliorated the oxidative stress and histopathologic changes in chronic gastritis-associated H. pylori infections [61,62,63]. All together, these studies suggest that curcumin can be a useful supplement to improve the gastric mucosal protection against chronic inflammation and may prevent the carcinogenic changes in patients with chronic gastritis associated with H. pylori (Figure 2).…”