Flavonoid Glycosides From The Leaves Of &lt;i&gt;Daniellia oliveri&lt;/i&gt;

Ahmadu, AA; Haruna, Abdurrashid; Garba, M.; Sule, MI; Pateh, U. U.; Ebeshi, Benjamin U.; Sarker, SD

doi:10.4314/njnpm.v8i1.11821

Cited by 3 publications

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“…Cyanogenic glycosides were absent in the qualitative analysis. This was in line with previous publications by Hassan et al [16], Muanda [17]; Boye et al [12], Ahmadu et al [18], Alain et al [19]. The result of the acute toxicity test of D. oliveri showed that the extract was not lethal even at the highest dosage (5000 mg/kg body weight) administered.…”

Section: Discussionsupporting

confidence: 92%

Pharmacognostic Screening and Antimalaria Activity of Methanol Bark Extract of Daniellia oliveri (ROLFE) Hutch. & Dalz. [Fabaceae] Extract on Plasmodium berghei Infected Mice

Theodora

Chidera²,

Estella³

et al. 2023

J. Pharm. Res. Int.

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Introduction: Malaria parasite infection has remained a global leading cause of death and disability in which about 50% of the world population is estimated to be at risk, especially in low and middle income countries. Aim: This research is designed to evaluate the pharmacognostic, phytochemical profile, and investigate its antimalarial activity by analysing different hematological indices of the methanolic bark extract of Daniellia oliveri, a plant belonging to the family of fabaceae. Methods: The barks of this plants were collected, cleared, dried, pulverized and sequentially extracted with petroleum ether, n-hexane, ethyl acetate, methanol and aqueous using the soxhlet extractor. Acute toxicity studies (LD50) for the methanol bark extract was studied using standard method. Phytochemical and pharmacognostic screening was carried out using standard methods, its hematological analysis were investigated using standard methods. The antimalarial activity of the methanol bark extract Daniellia oliveri, was evaluated at different doses of 100, 200 and 400mg/kg using in-vivo models. Results: The plant is a tall slender tree with a dark grey colour. The following extractive values were obtained petroleum ether (0.600±0.10), n-hexane (0.667±0.88), ethyl acetate (1.600±0.10), methanol (8.400±0.10) and aqueous (6.200±0.10).The methanol extract had the hightest extractive value and was found to be non-toxic at dose 5000mg/kg. The qualitative and quantitative phytochemical analyses reveals the presence of alkaloids (10.179±0.61), saponins (1.674±0.43), tannins (10.738±0.61), flavonoids (3.923±0.15), steroids (2.665±0.07), phenols (134.604±14.83), terpenoids (22.436±4.87), glycosides (14.485±0.08), reducing sugars (4.138±1.36), soluble carbohydrates but absence of cyanogenic glycosides The pharmacognostic parameters values were obtained as follows, total ash value (5.600±0.10), acid insoluble ash value (2.800±0.88), water soluble ash value (0.500±0.10), moisture content (13.933±0.12), bitterness value , foaming index (less than 100), swelling index (2.867±0.99). Conclusion: This result has shown that the hematological analysis carried out exhibited significant improvement in PCV, RBC and Hb when administered the plant extract compared to the standard group. It exhibited significant increase in platelet and lymphocyte while reduction in neutrophil compared to the standard group. The increased hematological indices indicate a better transportation capacity of the red blood cells and this should be attributed to the antimalarial properties of the extract. Also, the white blood differential count indicates a boost in the immune system of the treated P. berghei infected mice. This study justifies the ethno-medicinal use of D. oliveri in the management of malaria.

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Section: Discussionsupporting

confidence: 92%

Pharmacognostic Screening and Antimalaria Activity of Methanol Bark Extract of Daniellia oliveri (ROLFE) Hutch. & Dalz. [Fabaceae] Extract on Plasmodium berghei Infected Mice

Theodora

Chidera²,

Estella³

et al. 2023

J. Pharm. Res. Int.

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“…The leaf part was reported to have antibacterial activity (Ahmadu et al, 2006). Previous phytochemical studies on the leaf led to isolation of two furanocoumarines, psoralen and bergapten (Ahmadu et al, 2004), two flavonoid glycosides which are Kaempferol-3-o-rutinosides and Quercitin-3-o-rutinosides (Ahmadu et al, 2006). The present study to the best of our search is the first report to evaluate the leaf part of the plant for analgesic and inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of analgesic and anti-inflammatory effects of ethanol extract of <i>Ficus iteophylla</i> leaves in rodents

Sule²,

Am³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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This study was undertaken to investigate the leaf part of the plant for analgesic and anti-inflammatory. The ethanol extract of Ficus iteophylla leaves (100, 200, and 400mgkg -1 , i.p) was evaluated for analgesic and anti-inflammatory activities. The analgesic effect was studied using acetic acid-induced abdominal constriction and hot plate test in mice, while the antiinflammatory effect was investigated using carrageenan induced paw oedema in rats. The ethanol extract at 100mgkg-1 , and 400mgkg -1 significantly (P< 0.05) inhibited acetic acid induced writhes by 1.50 ± 0.43, 3.0 ± 0.82 and 1.0 ± 0.82 respectively. It also exhibited significantly (P< 0.05) anti-inflammatory by 0.11 ± 0.02, 0.11 ± 0.03, 0.08 ± 0.01 respectively. The preliminary phytochemical screening of the plant extract revealed the presence of flavonoids, steroids, tannins and saponins while the effect of flavonoids, steroids and tannins on analgesic and inflammatory has been reported. The intraperitoneal median lethal dose (LD 50 ) value of the extract was found to be 3807.8 mgkg -1 body weights. The result obtained from this study shows that the extract of Ficus iteophylla contained phytochemical constituents with analgesic and anti-inflammatory activities, therefore the leaf part of the plant could be used in the management of pain and inflammatory conditions.

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“…The MIC of the leaf extracts against C. albicans and T. rubrum (3.125 mg/ml) was lower compared to the stem bark suggestive of better activity Nigeria [ 24 ] Stem bark Aqueous (cold and hot), methanol, Ethanol, and acetone In vitro (broth dilution method and colony count) 6.25, 12.5, 25, 50 and 100 mg/ml The organic extracts are highly active at the lowest concentrations. The MIC of the aqueous (cold and hot) extracts was similar to the organic extracts, though cold aqueous extract was insensitive to E. faecalis , K. pneumonia Nigeria [ 61 ] Leaves Aqueous, ethanol, and n-butanol crude and fractions (A-D) In vitro NS All fractions showed good activity against S. aureus while the n-butanol and the four fractions revealed considerable activity against fungus Nigeria [ 49 , 59 ] Leaves and bark Ethanol In vitro (agar diffusion method) 0.84, 1.88, 3.75, 7.5, 15, 30 and 60 mg/ml The highest ZID was reported at 15 mm ( S. dysentariae ). Extracts are all active against tested microorganisms above 7.5 mg/ml indicating the antimicrobial potential.…”

Section: Results (Pharmacological and Safety Properties)mentioning

confidence: 99%

“…1 C), and quercimeritrin ( Fig. 1 D)] from the ethanolic fraction of the leaves have also been reported [ 49 ]. Similarly, two triterpenoids; a lupane and oleanane −9(11), 12-diene acid identified as Lup-20(29)-en-3-ol [Lupenol ( Fig.…”

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae)

Balogun,

Ajao,

Sabiu

2023

Heliyon

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Flavonoid Glycosides From The Leaves Of <i>Daniellia oliveri</i>

Cited by 3 publications

References 0 publications

Pharmacognostic Screening and Antimalaria Activity of Methanol Bark Extract of Daniellia oliveri (ROLFE) Hutch. & Dalz. [Fabaceae] Extract on Plasmodium berghei Infected Mice

Pharmacognostic Screening and Antimalaria Activity of Methanol Bark Extract of Daniellia oliveri (ROLFE) Hutch. & Dalz. [Fabaceae] Extract on Plasmodium berghei Infected Mice

Evaluation of analgesic and anti-inflammatory effects of ethanol extract of <i>Ficus iteophylla</i> leaves in rodents

A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae)

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