Evaluation of analgesic and anti-inflammatory effects of ethanol extract of <i>Ficus iteophylla</i> leaves in rodents

Abstract

This study was undertaken to investigate the leaf part of the plant for analgesic and anti-inflammatory. The ethanol extract of Ficus iteophylla leaves (100, 200, and 400mgkg -1 , i.p) was evaluated for analgesic and anti-inflammatory activities. The analgesic effect was studied using acetic acid-induced abdominal constriction and hot plate test in mice, while the antiinflammatory effect was investigated using carrageenan induced paw oedema in rats. The ethanol extract at 100mgkg-1 , and 400mgkg -1 significantly (P< 0.05) inhibited acetic acid induced writhes by 1.50 ± 0.43, 3.0 ± 0.82 and 1.0 ± 0.82 respectively. It also exhibited significantly (P< 0.05) anti-inflammatory by 0.11 ± 0.02, 0.11 ± 0.03, 0.08 ± 0.01 respectively. The preliminary phytochemical screening of the plant extract revealed the presence of flavonoids, steroids, tannins and saponins while the effect of flavonoids, steroids and tannins on analgesic and inflammatory has been reported. The intraperitoneal median lethal dose (LD 50 ) value of the extract was found to be 3807.8 mgkg -1 body weights. The result obtained from this study shows that the extract of Ficus iteophylla contained phytochemical constituents with analgesic and anti-inflammatory activities, therefore the leaf part of the plant could be used in the management of pain and inflammatory conditions.

Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata

“…Acetic acid induces the analgesic effect indirectly via endogenous mediators present in inflammatory processes such as bradykinin, serotonin, histamine, substance P and prostaglandins, which stimulate peripheral nociceptive neurons that respond to anti-inflammatory drugs [37,38]. Our hypothesis in the present study is that the antinociceptive action of the extract occurs through the peripheral reduction in prostaglandin synthesis, caused by the inhibition of cyclooxygenases as suggested by Abdulmalik et al [39] when verifying the antinociceptive effect with the same pain model in the Ficus iteophylla leaves extract.…”

Evaluation of analgesic activity of the methanol extract from the galls of Quercus infectoria alone and as an adjuvant in wistar rats

“…21,22 Studies have reported the role of tannin in providing antinociception. 23,24 Tannin has been suggested to inhibit prostaglandin synthesis. 25 Based on the observations made in our study, the probable mechanism of analgesia exhibited by tannin is spinally mediated.…”

Plants and Plant Constituents with Analgesic and Anti-inflammatory Activities: A Systematic Review

“…Additionally, the ethanolic extract has the ability to reduce carrageenan-induced paw edema in rats which confirm its antiphlogistic property. 34…”