Flavonoid compounds isolated from Tibetan herbs, binding to GABAA receptor with anxiolytic property

Liu, Zenggen; Silva, Joshua; Shao, Amy S.; Liang, Jing; Wallner, Martín; Shao, Xuesi M.; Li, Mingzhu; Olsen, Richard W.

doi:10.1016/j.jep.2020.113630

Cited by 18 publications

(17 citation statements)

References 40 publications

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“…External symptoms were estimated through hole cross checks to complete the approval of anxiousness. Some studies have found that plant extracts rich in alkaloids, glycosides, and flavonoids have sedative, anxiolytic, and antiepileptic properties that interfere with their properties at the benzodiazepine site of the GABAergic complex structure or are immediate or aberrant modulators that are responsible for increases in GABA activity in the brain that cause drowsiness and facies [ 33 , 34 ]. It seems that the phytochemicals included in the extract of Polyalthia suberosa leaves contribute to the relaxing and sleep-inducing actions on the CNS, at least to a limited degree.…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological-Based Validation of Polyalthia suberosa Leaf Extract in Neurological, Hyperalgesic, and Hyperactive Gut Disorders Using Animal Models

Amin

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. The aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activities. For neurological studies, the hole cross, hole board, open field, and thiopental sodium-induced sleep duration measurement methodologies were used. The castor oil-induced diarrhea inhibition test was used to assess antidiarrheal action, and the acetic acid-induced writhing inhibition test was used to determine analgesic effectiveness. The extract was given in doses of 250 and 500 mg kg−1 body weight. As a standard drug, diazepam at a dosage of 3 mg kg−1 was used. The extract was also given to groups, and sleep time was measured and recorded. The onset of the anxiolytic effect of the extract at both doses was found to be significant ( p < 0.001), and sleep time increased to 273 minutes. For assessing analgesic activity, the extract along with standard diclofenac was administered and found to be 55.02 percent and 64.33 percent, respectively, for the extracts, and diclofenac was found to be 67.44 percent ( p < 0.001). For antidiarrheal activity, it was compared with the standard drug, loperamide. The decrease for plant extracts was 50.07 percent and 70.06 percent at 250 mg kg−1 and 500 mg kg−1, respectively, whereas it was 85.01 percent for loperamide (3 mg kg−1) ( p < 0.00). In this study, it was found that ethyl acetate extract of Polyalthia suberosa leaves had strong CNS depressant, analgesic, and antidiarrheal activities, which indicates that it may be used in contemporary medicine.

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacological-Based Validation of Polyalthia suberosa Leaf Extract in Neurological, Hyperalgesic, and Hyperactive Gut Disorders Using Animal Models

Amin

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Several plant flavones have been assessed based on their traditional uses to reduce anxiety (Liu et al. 2021 ). In a study by Malathi and Ravindran ( 2015 ), the antidepressant and anxiolytic activities of the methanolic extract of its flower were evaluated.…”

Section: Discussionmentioning

confidence: 99%

New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca : an in vivo and in silico approach

Pushpa

Jayanthi

Rashmi

et al. 2022

Pharmaceutical Biology

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Context Michelia champaca L. (Magnoliaceae) has been known since ancient times for its rich medicinal properties. Objective The ethanol extract of Michelia champaca leaves (EEMC) was evaluated on depression and anxiety using in vivo and in silico studies Materials and methods Swiss albino mice were divided into control, standard, 100 and 200 mg/kg b.w. EEMC groups and for drug administration using oral gavage. The antidepressant activity was evaluated using forced swim test (FST) and tail suspension test (TST) whereas the anxiolytic activity through elevated plus maze and light and dark tests. The in silico studies included molecular docking against human potassium channel KCSA-FAB and human serotonin transporter, and ADME/T analysis. Results Open arm duration and entries were comparable between 200 mg/kg b.w. group (184.45 ± 1.00 s and 6.25 ± 1.11, respectively) and that of diazepam treated group (180.02 s ± 0.40 and 6.10 ± 0.05, respectively). Time spent in the light cubicle was higher (46.86 ± 0.03%), similar to that of diazepam (44.33 ± 0.64%), suggesting its potent anxiolytic activity. A delayed onset of immobility and lowered immobility time was seen at both the treatment doses (FST: 93.7 ± 1.70 and 89.1 ± 0.40 s; TST: 35.05 ± 2.75 and 38.50 ± 4.10 s) and the standard drug imipramine (FST: 72.7 ± 3.72 and TST: 30.01 ± 2.99 s), indicative of its antidepressant ability. In silico studies predicted doripenem to induce anxiolytic and antidepressant activity by inhibiting human potassium channel KCSA-FAB and human serotonin transporter proteins, respectively. Conclusions EEMC is a rich source of bioactive compounds with strong antidepressant and anxiolytic properties.

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“…Flavonoids are polyphenols found in many natural products such as medicinal plant families and obtained from leaves, stems, roots or barks. Consumption of these parts known to be rich in flavonoids has been reported to result in anti-anxiety effect [24,25]. In addition to the anxiolytic effect, flavonoids were shown to prevent neuro-degeneration [26].…”

Section: Discussionmentioning

confidence: 99%

Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission

Ngaibi¹,

Taïwé²,

Njapdounke³

et al. 2021

GSC Biol. and Pharm. Sci.

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Ethnopharmacological relevance: The leaves and stems of Lippia multiflora Moldenke (Verbenaceae) are used in traditional medicine to treat depression, anxiety and epilepsy. Aim of the study: The present study investigated the anxiolytic-like effects of Lippia multiflora aqueous extracts in experimental models of anxiety. Materials and methods: Elevated plus maze and open field tests were used to evaluate anxiety and exploratory behaviour. The possible mechanism of action of Lippia multiflora were investigated after pretreatment of animal with agonist and antagonist of serotonin receptors, such as: mCPP, a partial agonist at the 5-HT2C receptors; Way-100635, a selective 5-HT1A receptors antagonist; and DOI, the 5-HT2A/2C receptors agonist. The levels of monoamine neurotransmitters were evaluated in the brain. Results: In the elevated plus maze, Lippia multiflora increased the number of entries into and percentage of time in open arms, and reduced rearing, head dipping, and percentage of time in closed arms. These effects were blocked with the agonist and antagonist of serotonin receptors. In the open field, Lippia multiflora increased crossing and reduced rearing and defecation. The endogenous levels of noradrenaline, dopamine and serotonin in the brain homogenates remain comparable to that distilled water-treated animals. Conclusion: It could be concluded that Lippia multiflora aqueous extracts, used in traditional medicine in Cameroon for the treatment of depression, anxiety and epilepsy seemed to possess anxiolytic properties in mice. These effects might be mediated by serotonin receptors, but not by modulation of the levels of monoamine neurotransmitters when the extract is administered once after one hour.

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Flavonoid compounds isolated from Tibetan herbs, binding to GABAA receptor with anxiolytic property

Cited by 18 publications

References 40 publications

Ethnopharmacological-Based Validation of Polyalthia suberosa Leaf Extract in Neurological, Hyperalgesic, and Hyperactive Gut Disorders Using Animal Models

Ethnopharmacological-Based Validation of Polyalthia suberosa Leaf Extract in Neurological, Hyperalgesic, and Hyperactive Gut Disorders Using Animal Models

New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca : an in vivo and in silico approach

Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission

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