Flavonoid chemistry of Fallopia section Fallopia (Polygonaceae)

Kim, Min-Ha; Park, Jin Hee; Park, Chong-Wook

doi:10.1016/s0305-1978(99)00084-8

Cited by 19 publications

(18 citation statements)

References 6 publications

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“…Rutin, hyperoside, kaempferol, apigenin and luteolin were not identifi ed in any of the extracts tested, altrough they are mentioned in the literature [16]. Instead, we have shown the presence of free phenolic acids (chlorogenic acid, caffeic acid) in the tested extracts, a fi nding not previously reported.…”

Section: Discussioncontrasting

confidence: 56%

“…Th e chemical composition has been scarcely investigated and only the fl avonoid fraction has been characterized from a qualitative point of view, for taxonomic purposes; the aerial parts contained heterosides of kaempferol (3-Ogalactoside, 3-O-glucoside), quercetin (3-O-galactoside, 3-O-glucoside), apigenin (6-C-glucoside, 8-C-glucoside) and luteolin (8-C-glucoside) [16].…”

Section: Introductionmentioning

confidence: 99%

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Botanical Investigation of Fallopia Dumetorum (L.) Holub (Polygonaceae) and Qualitative and Quantitative Assessment of its Polyphenolic Compounds

Olaru

Ancuceanu

Anghel

et al. 2014

Acta Medica Marisiensis

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Background: Considering the continuous need to fi nd new sources of polyphenolic compounds, we performed a pharmacognostical examination of the species Fallopia dumetorum (L.) Holub sin. Polygonum dumetorum L. (Polygonaceae). The plant is common in the plain regions of Romania and has not been exploited therapeutically. Materials and method: Microscopic examination was performed on cross-sections, surface preparations and on powder obtained from the aerial parts of the fl owering plant. Qualitative chemical analysis was realized by phytochemical screening and thin layer chromatography (TLC). Phenolic compounds were assayed by spectrophotometric methods: fl avonoids expressed as rutin (with aluminium chloride), phenolcarboxylic acids expressed as chlorogenic acid (Arnow's method) and proanthocyanidins expressed as cyanidin chloride (in acidic medium, by conversion to anthocyanins). Results:The species has the following microscopic characters: anomocytic stomata, druses of calcium oxalate, sessile, pluricellular glandular hairs and pollen grains with smooth exine. Polysaccharides, reducing compounds, coumarins, sterols/triterpenes, phenol-carboxylic acids, fl avones, proanthocyanidins, tannins and carotenoids were identifi ed by phytochemical screening; chlorogenic acid, caffeic acid, quercetin and stigmasterol/beta-sitosterol were detected by TLC. F. dumetori herba has a content of 1.49 ± 0.105 g% polyphenol-carboxylic acids, 0.40 ± 0.087g% fl avonoids and 0.18 ± 0.002 g% proanthocyanidins. Conclusions:We have characterized pharmacognostically the native species F. dumentorum. Due to its content in phenolic compounds it might serve as a source of polyphenols.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Botanical Investigation of Fallopia Dumetorum (L.) Holub (Polygonaceae) and Qualitative and Quantitative Assessment of its Polyphenolic Compounds

Olaru

Ancuceanu

Anghel

et al. 2014

Acta Medica Marisiensis

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“…In F. aubertii, glycosides of quercetin, kaempferol, apigenin, luteolin, myricetin and several chromones structures have been identified (29,32,33). With the exception of rhamnetin, isorhamnetin and characteristic flavonoids, all other flavonoids have also been found in F. dumetorum (28).…”

Section: Introductionmentioning

confidence: 99%

“…These plants are invasive and can easily produce biomass and can therefore be introduced in crops (27) (25). Chemotaxonomic studies on the genus Fallopia have shown that all species contain flavonoids with a profile relatively uniform for all species and that quercetin glycosides are the major constituents (28,29). The flavonoid fraction of F. convolvulus consist of glycosides of quercetin, kaempferol, myricetin, apigenin, luteolin, rhamnetin and isorhamnetin (28,30).…”

Section: Introductionmentioning

confidence: 99%

“…Chemotaxonomic studies on the genus Fallopia have shown that all species contain flavonoids with a profile relatively uniform for all species and that quercetin glycosides are the major constituents (28,29). The flavonoid fraction of F. convolvulus consist of glycosides of quercetin, kaempferol, myricetin, apigenin, luteolin, rhamnetin and isorhamnetin (28,30). Three characteristic flavonoid structures have also been found in this species: falloconvolin A and B and quercetin-3-O-(2-E-esinapoxyl)-glucopyranoside (31).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer potential of selected Fallopia Adans species

et al. 2015

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Abstract. The aim of the present study was to determine the anticancer potential of three species belonging to the Fallopia genus (Polygonaceae): Fallopia convolvulus (F. convolvulus, Fallopia dumetorum (F. dumetorum) and Fallopia aubertii (F. aubertii). For this purpose, crude extracts were obtained and characterized for their phenolic and flavonoid total content and examined for their anticancer activity on three tumor cell lines: breast cancer (MCF7), colon carcinoma (Caco-2) and cervical cancer (HeLa) cells. The cytotoxic potential of the three species was assessed by MTT assay, cell cycle analysis and by the evaluation of mitochondrial membrane potential (MMP). The acute toxicity of the extracts was evaluated using one in vitro cell model (Vero cells, an African Green monkey kidney cell line) and two invertebrate in vivo models (Daphnia magna and Artemia salina). The highest total phenolic and flavonoid content was found in the F. aubertii flower extracts. The cytotoxic effects of the extracts from F. aubertii and F. convolvulus on all three cell lines were examined at concentrations ranging from 3 to 300 µg/ml. G2/M cell cycle arrest was induced by all the extracts, and a significant increase in the subG1 cell population was observed. The hydroethanolic extract from the flowers of F. aubertii induced cell apoptosis more rapidly than the other extracts. The MMP indicates the involvement of the mitochondria in the induction of apoptosis. A positive correlation between the total phenolic content of the extracts and the IC 50 values against the HeLa cells was also noted. None of the extracts exhibited significantly toxic effects. Considering the antitumor potential of F. aubertii and F. convolvulus, these two species may represent a good source of plant extracts with anticancer properties. IntroductionCancer is the main cause of mortality and morbidity in Europe following cardiovascular diseases and represents the uncontrolled growth and spread of cells that arises from a change in one single cell (1). Each year, millions of individuals are diagnosed with cancer. The disease accounts for the death of approximately 3.5 million individuals annually worldwide (2). It was estimated that only in Europe, in 2012, 3.45 million new cases of cancer were noted, excluding non-melanoma skin cancer, and 1.75 million deaths occurred from cancer (3).Throughout history, plant extracts and their purified active components have been the backbone of cancer chemotherapeutics (4). Additionally, structural analogues have been obtained by molecular modifications of the natural compounds and have reinforced the anticancer arsenal (5). It is estimated that over 70% of anticancer compounds are either natural products, or natural product-derived substances (6). The rich diversity of the chemical structures provided by natural resources offers valuable templates for exploring novel molecular scaffolds and is the most significant source of new drug developments (7).Over the past two decades, flavonoid-rich plant extracts and isolated flav...

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