Fixation of bioactive calcium alkali phosphate on Ti6Al4V implant material with femtosecond laser pulses

Symietz, Christian; Lehmann, E.; Gildenhaar, Renate; Koter, R.; Berger, Georg; Krüger, Jörg

doi:10.1016/j.apsusc.2010.10.046

Cited by 17 publications

(4 citation statements)

References 11 publications

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“…Recently, FSL was employed to modify surface chemicals on Ti implants to form calcium alkali phosphate layer. 33,34 Photochemical reaction could be induced on the surface when it was treated in solvent along with the removable optical physics substances. During the reaction, ions and particles in the solvent were activated to bond with the implant materials.…”

Section: ■ Introductionmentioning

confidence: 99%

“…By adopting FSL irradiation and ablation, different surface structures could be processed on various solid materials. ,− Our previous studies also showed the feasibility − that a variety of surface patterns such as stripes, grooves, pores, as well as nanoparticles were obtained on pure Ti and NiTi alloy. Recently, FSL was employed to modify surface chemicals on Ti implants to form calcium alkali phosphate layer. , Photochemical reaction could be induced on the surface when it was treated in solvent along with the removable optical physics substances. During the reaction, ions and particles in the solvent were activated to bond with the implant materials. − …”

Section: Introductionmentioning

confidence: 99%

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Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration

Liang

Wang

Yang

et al. 2013

ACS Appl. Mater. Interfaces

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Surface microstructure and chemical composition of the implant are very important for its osseointegration in vivo. In this paper, a hierarchical micropattern covered with calcium phosphate (Ca/P phase) was obtained on titanium (Ti) implant surface by femtosecond lasers (FSL) irradiation in hydroxyapatite suspension. The hierachical micropattern as well as Ca/P phase increased osteoblastic cell adhesion. Higher expression of osteogenic markers (osteocalcin, osteopontin, and runt related transcription factor-2) on the surface treated by FSL of 2.55 J/cm(2) indicated the favorable effect of laser treatment on cell differentiation. In vivo studies were carried out to evaluate the effect of laser treatment and Ca/P deposition on the osseointegration. It showed that the binding capacity between bone and FSL-treated Ti implants was obviously stronger than that between bone and polished or sand blasting and acid etching (SLA) Ti implants. Bone trabecula surrounded the FSL-treated implants without fibrous tissue after 8-week implantation. Also, higher bone mineral density was seen surrounding the FSL-treated implants. Our in vitro and in vivo studies demonstrated that the FSL induced micropattern and Ca/P phase had positive effects on the acceleration of early osseointegration of Ti implants with bone tissue.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration

Liang

Wang

Yang

et al. 2013

ACS Appl. Mater. Interfaces

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“…In the past few decades, some bioactive materials containing phosphate (P) element have been reported including calcium phosphate (Ca-P) biomaterials, such as hydroxyapatite, tricalcium phosphate and calcium phosphate cements, and P-containing bioglasses/bioceramics/cements 1 – 3 . These P-containing bioactive materials that exhibit excellent biocompatibility and bioactivity have been applied to bone repair and used as a bone substitute in the form of particles, blocks and coatings 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

Wang

Wei

et al. 2017

Sci Rep

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Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 °C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.

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“…Recently, the traditional methods of stabilising the prosthesis such as bone cement fixation are largely substituted by bioactive fixation, which can stabilise the prosthesis in a short period of time because of its bioactive nature. The bioactive fixation technology requires that the implants possess not only high biocompatibility, but also excellent bioactivity [10, 11]. The most effective method for improving the bioactivity of the polymer is to combine bioactive ceramics, such as hydroxyapatite (HA) or calcium phosphate with substrate materials [12].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterisation of functional gradient hydroxyapatite reinforced poly (ether ether ketone) biocomposites

Pan

Shen

Chen

2013

Micro & Nano Letters

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Biomaterials usually require simultaneous possession of excellent performances such as bioactivity, mechanical and bio-tribological properties to meet biomedical application requirements. In this reported work, the bioactive and mechanical properties of biocomposites were simultaneously optimised according to the functional gradient design idea. The functional gradient nano-hydroxyapatite reinforced polyetheretherketone (nano-HA/PEEK) biocomposites were fabricated through the layer-by-layer casting method and incorporation with thermal pressure moulding technology. The microstructure and morphology were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). The result of the XRD study verified that the crystallinity of the PEEK matrix obviously improved after heat treatment. The SEM observation revealed that the size of HA particles in the biocomposites was in the nanometre scale. Furthermore, two typical morphologies such as encapsulated-and dimple-like microstructures were observed by SEM. The FTIR study showed that the interaction between nano-HA particles and the PEEK molecule existed. Both the SEM and FTIR studies results revealed that the morphology and microstructure in the functional gradient HA/PEEK biocomposites were beneficial for the improvement of the mechanical properties of the gradient biocomposites.

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Fixation of bioactive calcium alkali phosphate on Ti6Al4V implant material with femtosecond laser pulses

Cited by 17 publications

References 11 publications

Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration

Femtosecond Laser-Induced Micropattern and Ca/P Deposition on Ti Implant Surface and Its Acceleration on Early Osseointegration

Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

Fabrication and characterisation of functional gradient hydroxyapatite reinforced poly (ether ether ketone) biocomposites

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