Fitness Moderates Glycemic Responses to Sitting and Light Activity Breaks

McCarthy, Matthew; Edwardson, Charlotte L.; Davies, Melanie J.; Henson, Joseph; Bodicoat, Danielle H.; Khunti, Kamlesh; Dunstan, David W.; King, James A.; Yates, Thomas

doi:10.1249/mss.0000000000001338

Cited by 35 publications

(32 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aim of the intervention will be to promote and maintain at least a 60 min per day reduction in daily sitting time compared to usual practice at 24 months. Recent experimental evidence has demonstrated a reduction in glucose, insulin and blood pressure following regular standing and walking breaks (i.e., every 20–30 min), with total reductions in sitting varying from 28 min to 60 min across the course of a day [ 12 , 13 , 15 , 16 , 18 ]. Furthermore, using statistical modelling we have observed that interchanging 30 mins/day of sitting (measured with the activPAL) with standing and stepping is associated with favourable differences in insulin sensitivity [ 9 ] and inflammation [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers: study protocol

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundOffice-based workers typically spend 70–85% of working hours, and a large proportion of leisure time, sitting. High levels of sitting have been linked to poor health. There is a need for fully powered randomised controlled trials (RCTs) with long-term follow-up to test the effectiveness of interventions to reduce sitting. This paper describes the methodology of a three-arm cluster RCT designed to determine the effectiveness and cost-effectiveness of the SMART Work & Life intervention, delivered with and without a height-adjustable desk, for reducing daily sitting.Methods/designA three-arm cluster RCT of 33 clusters (660 council workers) will be conducted in three areas in England (Leicester; Manchester; Liverpool). Office groups (clusters) will be randomised to the SMART Work & Life intervention delivered with (group 1) or without (group 2) a height-adjustable desk or a control group (group 3). SMART Work & Life includes organisational (e.g., management buy-in, provision/support for standing meetings), environmental (e.g., relocating waste bins, printers), and group/individual (education, action planning, goal setting, addressing barriers, coaching, self-monitoring, social support) level behaviour change strategies, with strategies driven by workplace champions. Baseline, 3, 12 and 24 month measures will be taken. Primary outcome: Objectively measured daily sitting time (activPAL3). Secondary outcomes: objectively measured sitting, standing, stepping, prolonged sitting and moderate-to-vigorous physical activity time and number of steps at work and daily; objectively measured sleep (wrist accelerometry). Adiposity, blood pressure, fasting glucose, glycated haemoglobin, cholesterol (total, HDL, LDL) and triglycerides will be assessed from capillary blood samples. Questionnaires will examine dietary intake, fatigue, musculoskeletal issues, job performance and satisfaction, work engagement, occupational and general fatigue, stress, presenteeism, anxiety and depression and sickness absence (organisational records). Quality of life and resources used (e.g. GP visits, outpatient attendances) will also be assessed. We will conduct a full process evaluation and cost-effectiveness analysis.DiscussionThe results of this RCT will 1) help to understand how effective an important simple, yet relatively expensive environmental change is for reducing sitting, 2) provide evidence on changing behaviour across all waking hours, and 3) provide evidence for policy guidelines around population and workplace health and well-being.Trial registrationISRCTN11618007. Registered on 21 January 2018.

show abstract

Section: Methodsmentioning

confidence: 99%

A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers: study protocol

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…These links between sedentary behaviour and health and work related outcomes are important because the estimated costs of presenteeism and absenteeism in the United Kingdom are reported to be more than £30bn ($39bn; €34bn), with presenteeism costing over twice as much as absenteeism. 14 More positively, reductions in sitting and breaking up sitting through standing and walking in acute experimental settings have led to improvements in important cardiometabolic markers of health such as glucose and insulin levels and blood pressure, 15 16 17 18 19 20 21 22 and feelings of fatigue and vigour. 23 24 …”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial

Edwardson

Yates

Biddle

et al. 2018

BMJ

169

254

View full text Add to dashboard Cite

ObjectivesTo evaluate the impact of a multicomponent intervention (Stand More AT (SMArT) Work) designed to reduce sitting time on short (three months), medium (six months), and longer term (12 months) changes in occupational, daily, and prolonged sitting, standing, and physical activity, and physical, psychological, and work related health.DesignCluster two arm randomised controlled trial.SettingNational Health Service trust, England.Participants37 office clusters (146 participants) of desk based workers: 19 clusters (77 participants) were randomised to the intervention and 18 (69 participants) to control.InterventionsThe intervention group received a height adjustable workstation, a brief seminar with supporting leaflet, workstation instructions with sitting and standing targets, feedback on sitting and physical activity at three time points, posters, action planning and goal setting booklet, self monitoring and prompt tool, and coaching sessions (month 1 and every three months thereafter). The control group continued with usual practice.Main outcome measuresThe primary outcome was occupational sitting time (thigh worn accelerometer). Secondary outcomes were objectively measured daily sitting, prolonged sitting (≥30 minutes), and standing time, physical activity, musculoskeletal problems, self reported work related health (job performance, job satisfaction, work engagement, occupational fatigue, sickness presenteeism, and sickness absenteeism), cognitive function, and self reported psychological measures (mood and affective states, quality of life) assessed at 3, 6, and 12 months. Data were analysed using generalised estimating equation models, accounting for clustering.ResultsA significant difference between groups (in favour of the intervention group) was found in occupational sitting time at 12 months (−83.28 min/workday, 95% confidence interval −116.57 to −49.98, P=0.001). Differences between groups (in favour of the intervention group compared with control) were observed for occupational sitting time at three months (−50.62 min/workday, −78.71 to −22.54, P<0.001) and six months (−64.40 min/workday, −97.31 to −31.50, P<0.001) and daily sitting time at six months (−59.32 min/day, −88.40 to −30.25, P<0.001) and 12 months (−82.39 min/day, −114.54 to −50.26, P=0.001). Group differences (in favour of the intervention group compared with control) were found for prolonged sitting time, standing time, job performance, work engagement, occupational fatigue, sickness presenteeism, daily anxiety, and quality of life. No differences were seen for sickness absenteeism.ConclusionsSMArT Work successfully reduced sitting time over the short, medium, and longer term, and positive changes were observed in work related and psychological health.Trial registrationCurrent Controlled Trials ISRCTN10967042.

show abstract

“…Sitting is a typical way to relax and get efficient storage of energy in a short time 1 . As a common type of sitting behavior, sedentariness refers to any sitting behavior with an energy expenditure ≤1.5 metabolic equivalents 2 .…”

Section: Introductionmentioning

confidence: 99%

Sedentary behaviors and risk of depression: a meta-analysis of prospective studies

et al. 2020

View full text Add to dashboard Cite

Epidemiological evidence on the association between sedentary behaviors and the risk of depression is inconsistent. We conducted a meta-analysis of prospective studies to identify the impact of sedentary behaviors on the risk of depression. We systematically searched in the PubMed and Embase databases to June 2019 for prospective cohort studies investigating sedentary behaviors in relation to the risk of depression. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated with random-effect meta-analysis. In addition, meta-regression analyses, subgroup analyses, and sensitivity analyses were performed to explore the potential sources of heterogeneity. Twelve prospective studies involving 128,553 participants were identified. A significantly positive association between sedentary behavior and the risk of depression was observed (RR = 1.10, 95% CI 1.03-1.19, I 2 = 60.6%, P < 0.01). Subgroup analyses revealed that watching television was positively associated with the risk of depression (RR = 1.18, 95% CI 1.07-1.30), whereas using a computer was not (RR = 0.99, 95% CI 0.79-1.23). Mentally passive sedentary behaviors could increase the risk of depression (RR = 1.17, 95% CI 1.08-1.27), whereas the effect of mentally active sedentary behaviors were non-significant (RR = 0.98, 95% CI 0.83-1.15). Sedentary behaviors were positively related to depression defined by clinical diagnosis (RR = 1.08, 95% CI 1.03, 1.14), whereas the associations were statistically nonsignificant when depression was evaluated by the CES-D and the Prime-MD screening. The present study suggests that mentally passive sedentary behaviors, such as watching television, could increase the risk of depression. Interventions that reduce mentally passive sedentary behaviors may prevent depression.

show abstract

Fitness Moderates Glycemic Responses to Sitting and Light Activity Breaks

Abstract: Individuals with low CRF gained the most metabolic benefit from breaking prolonged sitting with regular bouts of light walking.

Cited by 35 publications

References 24 publications

A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers: study protocol

A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART Work & Life intervention for reducing daily sitting time in office workers: study protocol

Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial

Sedentary behaviors and risk of depression: a meta-analysis of prospective studies

Contact Info

Product

Resources

About