Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice

Moolakkadath, Thasleem; Aqil, Mohd.; Ahad, Abdul; Imam, Syed Sarim; Praveen, Arshiya; Sultana, Yasmin; Mujeeb, Mohd; Iqbal, Zeenat

doi:10.1016/j.ijpharm.2019.01.067

Cited by 81 publications

(49 citation statements)

References 48 publications

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“…All topical novel formulations, such as the lipid carrier and vesicular systems, must have approved ingredients or GRAS materials [26][27][28][29][30][31]. Most excipients fall in the GRAS category or have been used in marketing products (Table 1) [7,9,13,[30][31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: History Of Lipid Carriers and Vesiclesmentioning

confidence: 99%

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

et al. 2021

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A selected active pharmaceutical ingredient must be incorporated into a cargo carrier in a particular manner so that it achieves its goal. An amalgamation of active pharmaceutical ingredients (APIs) should be conducted in such a manner that it is simple, professional, and more beneficial. Lipids/polymers that are known to be used in nanocarriers for APIs can be transformed into a vesicular formulation, which offers elegant solutions to many problems. Phospholipids with other ingredients, such as ethanol and water, form suitable vesicular carriers for many drugs, overcoming many problems related to poor bioavailability, poor solubility, etc. Ultraflexible liposomes are novel carriers and new frontiers of drug delivery for transdermal systems. Auxiliary advances in vesicular carrier research have been made, enabling polymer-coated ethanolic liposomes to avoid detection by the body’s immune system—specifically, the cells of the reticuloendothelial system. Ultraflexible liposomes act as a cargo system and a nanotherapeutic approach for the transport of therapeutic drugs and bioactive agents. Various applications of liposome derivatives in different diseases are emphasized in this review.

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Section: History Of Lipid Carriers and Vesiclesmentioning

confidence: 99%

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

et al. 2021

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“…Malignant melanoma is causative around 75% of deaths, which is associated with skin cancer. Fisetin has significant effect on production of free fatty acids, tumor incidence, IL‐1α, TNF‐α, and antioxidant enzymes (glutathione and catalase contents) in ultravoilet‐induced skin cancer rats (Moolakkadath et al., 2019). YB‐1 leads to cell proliferation and invasion through promoting epithelial‐to‐mesenchymal transition.…”

Section: Cancer Perspectivesmentioning

confidence: 99%

Fisetin: An anticancer perspective

Imran

Saeed

Gilani

et al. 2020

Food Science & Nutrition

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“…This is mainly due to the ethanol it contains, which could interfere with the orderly SC arrangement, contributing to better drug penetration across the SC barrier. Binary ethosome (BE) further enhances these properties by addition of other alcohols (such as propylene glycol (PG)), which is favorable to increase the drug solubility, improve the drug entrapment efficiency and stability of the formulation [7]. On the other hand, transethosome (TE) contains edge activator (e.g., surfactants) and/or penetration enhancers [8] to increase the drug penetration by modifying the drug thermodynamic activity, and helping to solubilize it in the SC lipids.…”

Section: Introductionmentioning

confidence: 99%

Dermal Targeting Delivery of Terbinafine Hydrochloride Using Novel Multi-Ethosomes: A New Approach to Fungal Infection Treatment

Zhang

Zhu

et al. 2020

Coatings

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This research aimed to develop and evaluate a novel multi-ethosome (ME) system for the dermal delivery of terbinafine hydrochloride (TH) as a new approach to fungal infection treatment. TH-loaded MEs were successfully prepared using cinnamaldehyde as a penetration enhancer. Mean diameter of ME was found as ~100 nm with monodispersed size distribution. Drug entrapment efficiency reached up to 86% ± 1.4%. MEs exhibited excellent colloid stability and no drug leakage after 2 months of storage. In contrast to a commercial Lamisil® cream, ME significantly improved the targeting efficiency by increasing the fluidity of stratum corneum layer, revealed by attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR). The dermal targeting effect was visualized using confocal microscopy. Moreover, skin irritation and allergy tests showed that ME was not irritating to the skin. The improved antifungal activity of ME was proved in vitro on Candida albicans strains by minimal inhibitory concentration (MIC) assay. This study paves the way towards design of MEs for dermal fungal infection treatment.

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Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice

Cited by 81 publications

References 48 publications

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

Ultraflexible Liposome Nanocargo as a Dermal and Transdermal Drug Delivery System

Fisetin: An anticancer perspective

Dermal Targeting Delivery of Terbinafine Hydrochloride Using Novel Multi-Ethosomes: A New Approach to Fungal Infection Treatment

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