Fisetin: An anticancer perspective

Imran, Muhammad; Saeed, Farhan; Gilani, Syed Amir; Shariati, Mohammad Ali; Imran, Ali; Afzaal, Muhammad; Atif, Muhammad; Tufail, Tabussam; Anjum, Faqir Muhammad

doi:10.1002/fsn3.1872

Cited by 70 publications

(47 citation statements)

References 106 publications

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“…Given the wide distribution of herbal resources, their inexpensive nature, and the low levels of toxicity associated with herbal medicine-based therapies, they hold great promise as advantageous means of treating disease. Fisetin (3,7,3,4-tetrahydroxyflavone) is a flavonoid present within a range of fruits and vegetables including apples, onions, grapes, strawberries, and cucumbers at doses of 2-160 μ g/g [ 12 , 13 ]. Fisetin has previously been shown to inhibit monoamine oxidase activity associated with the norepinephrine and serotonin systems, thus exerting antidepressant activity [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Fisetin on Allergic Contact Dermatitis via Regulating the Balance of Th17/Treg in Mice

Song

Shen

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Allergic contact dermatitis (ACD) is a form of chronic cutaneous inflammatory disease of immunological origin that has adverse impacts on patient quality of life, underscoring the need for the development of safe and effective therapeutic agents to treat affected individuals. Fisetin is a Chinese herbal preparation that reportedly exhibits antitumor, antioxidant, antimicrobial, anticoagulatory, and antimalarial activity. In the current report, the immunomodulatory activity of fisetin was appraised by assessing its impact on balance between regulatory T (Treg) and Th17 cells in an ACD model. Methods. BALB/c mice ( n = 60 ) were randomized into control, ACD model, CTX positive control (20 mg/kg), and fisetin treatment groups (three dose levels: 2, 4, or 8 mg/kg). ACD induction was achieved by sensitizing mice on the shaved ventral abdomen via the application of 5% DNFB (50 μL) on days 1 and 2, followed by rechallenge in the right ear with 5% DNFB (20 μL) on day 5. Beginning on day 1, immunized mice were intraperitoneally injected with the appropriate fisetin dose (in saline) once per day for 7 days. On day 7, ear swelling, transcription factor expression, Th17/Treg cell populations, and cytokine production were assessed in vivo. Results. Fisetin treatment significantly suppressed ear swelling and associated inflammatory cell infiltration, besides reducing the production of Th17 cytokines (IL-17, TNF-α, and IL-6) and the expression of the Th17 lineage transcription factor RORγt while simultaneously enhancing Treg-specific cytokine production (TGF-β and IL-10) and the expression of the Treg lineage transcription factor Foxp3, thereby restoring the Th17/Treg cell in ACD mice. Conclusions. These data indicate that fisetin exhibits immunomodulatory activity and can alter the Th17/Treg cell balance, highlighting its potential value as a treatment drug for ACD.

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Section: Introductionmentioning

confidence: 99%

Effects of Fisetin on Allergic Contact Dermatitis via Regulating the Balance of Th17/Treg in Mice

Song

Shen

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Fisetin is another wellknown flavonol that has excellent anti-Parkinson's, anticancer and antioxidant activity. Nutritional supplements exhibited several pharmacological effects, as well as antiinflammatory and antioxidant activity [96]. Novel water-soluble fisetin/β-and γcyclodextrin complexes and polymeric micelles have been developed for medical applications and food industry [97,98].…”

Section: Flavonols and Nutraceutical And Pharmacological Fieldmentioning

confidence: 99%

Biotechnological Applications and Health-Promoting Properties of Flavonols: An Updated View

Gervasi

Calderaro

Barreca

et al. 2022

IJMS

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Flavonols are a subclass of natural flavonoids characterized by a remarkable number of biotechnological applications and health-promoting properties. They attract researchers’ attention due to many epidemiological studies supporting their usage. They are phytochemicals commonly present in our diet, being ubiquitous in the plant kingdom and, in particular, relatively very abundant in fruits and vegetables. All these aspects make flavonols candidates of choice for the valorization of products, based on the presence of a remarkable number of different chemical structures, each one characterized by specific chemical features capable of influencing biological targets inside the living organisms in very different manners. In this review, we analyzed the biochemical and physiological characteristics of flavonols focalizing our attention on the most promising compounds to shed some light on their increasing utilization in biotechnological applications in processing industries, as well as their suitable employment to improve the overall wellness of the humankind.

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“…The fisetin is a natural flavonol that has demonstrated high anti-tumor activity and capacity in chemoprevention [ 155 , 156 ]. Fisetin mediates histone demethylation to induce DNA damage and impair progression of pancreatic tumor cells [ 157 ].…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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Fisetin: An anticancer perspective

Cited by 70 publications

References 106 publications

Effects of Fisetin on Allergic Contact Dermatitis via Regulating the Balance of Th17/Treg in Mice

Effects of Fisetin on Allergic Contact Dermatitis via Regulating the Balance of Th17/Treg in Mice

Biotechnological Applications and Health-Promoting Properties of Flavonols: An Updated View

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

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