First use of inorganic copper silicate-transduced enzyme-free electrochemical immunosensor for carcinoembryonic antigen detection

Label-Free and Ultrasensitive Electrochemiluminescent Immunosensor Based on Novel Luminophores of Ce2Sn2O7 Nanocubes

“…Some available methods for CEA detection have been developed, such as fluorometry, amperometry, electrochemistry, and capillary electrophoresis . However, these analysis methods have some shortcomings, such as time-wasting, base-current interference, waste of materials, complicated instrumentation, etc.…”

“…6,7 Hence, highly selective and sensitive CEA detection in serum is of great prominence in clinical examination and pathological studies. Some available methods for CEA detection have been developed, such as fluorometry, 8 amperometry, 9 electrochemistry, 10 and capillary electrophoresis. 11 However, these analysis methods have some shortcomings, such as timewasting, base-current interference, waste of materials, complicated instrumentation, 12 etc.…”

Realizing the label-free sensitive detection of carcinoembryogenic antigen (CEA) in blood serum via a MNC-decorated flexible immunosensor

“…18 In this scenario, label-free electrochemical immunosensors can address the issues associated with labelled immunosensors, wherein, the analysis takes place by directly monitoring the reaction between the antigen–antibody immune complex, resulting in a shorter analysis time. 19 For label-free electrochemical immunosensors, effective and stable immobilization of the antibody on the electrode surface is the most critical step. 20 Therefore, the selection of a multifunctional substrate material for the effective immobilization of antibodies over the electrode surface is extremely desirable.…”

Label-free Electrochemical Impedance Spectroscopy Aptasensor for Ultrasensitive Detection of Lung Cancer Biomarker Carcinoembryonic Antigen

“…Disease detection is achieved by measuring the levels of biomarkers in blood, urine, and other body fluids. Carcinoembryonic antigen (CEA), an acidic glycoprotein with a relative molecular mass of 180 kDa, is of great importance for the development and monitoring of lung cancer ( Yang et al, 2018 ; Song et al, 2020 ). Usually, the CEA content in biological samples is very low, and the threshold value of CEA in human serum is 5.0 ng/ml.…”