First‐trimester screening markers are altered in pregnancies conceived after IVF/ICSI

Gjerris, A.; Loft, Anne; Pinborg, Anja; Christiansen, Michael; Tabor, Ann

doi:10.1002/uog.6254

Cited by 74 publications

(73 citation statements)

References 53 publications

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“…The PAPP-A level was also reduced in the previous studies by Gjerris et al (10), Amor et al (11), and Kagan et al (12), which was the largest study to date. The study reported that the PAPP-A levels were reduced 10% in IVF pregnancies.…”

mentioning

confidence: 58%

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

Matilainen

Peuhkurinen

Laitinen

et al. 2011

Fertility and Sterility

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mentioning

confidence: 58%

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

Matilainen

Peuhkurinen

Laitinen

et al. 2011

Fertility and Sterility

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“…Therefore, our proposed ultrasound-based method of screening for T21 could be considered as an alternative to CST, either as routine antenatal care or under special circumstances, e.g. in centers without certified biochemical analyzers or in patients after assisted reproductive techniques who demonstrate higher FPRs from CST at a level of 10.7% due to the significantly lower serum levels of PAPP-A [22]. It can also be considered in all women suffering from chronic diseases, e.g.…”

Section: Discussionmentioning

confidence: 99%

How Effective Is First-Trimester Screening for Trisomy 21 Based on Ultrasound Only?

Wiechec¹,

Knafel²,

Nocun³

et al. 2015

Fetal Diagn Ther

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Objective: To evaluate the most common first-trimester ultrasound features of fetuses with trisomy 21 (T21) and to examine the screening performance for Down syndrome (DS) using only ultrasound-based protocols. To investigate whether maternal age (MA) has an impact on the efficacy of the ultrasound-based screening methods. Methods: In a prospective study, 6,265 patients were examined. Two ultrasound-based risk calculation protocols were applied: ‘NT' (based on nuchal translucency) and ‘NT+' (based on NT and secondary markers). Results: A total of 5,696 patients were enrolled for analysis; 84 subjects with T21 were identified. Combinations of abnormal ultrasound markers were observed in only 1.2% of euploid fetuses compared to 71.5% of fetuses with T21. Among 17.9% of DS cases with cardiac anomaly, 14.3% comprised atrioventricular septal defects. For a false-positive rate of 3%, the detection rates of T21 were 73.8 and 91.7% for the ‘NT' and ‘NT+' protocols, respectively. The efficacy of both methods was affected by MA. Conclusions: Most of the fetuses with DS demonstrate a combination of ultrasound markers of aneuploidy in the first trimester. The ‘NT+' protocol is efficient and provides comparable performance as a combined screening test. It is a valuable method, especially when the access to biochemical analysis is restricted.

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“…Most studies showed decreased PAPP-A levels in ART pregnancies combined with unaltered levels of fβ-hCG [9,13,14,16,17,20,21] increased fβ-HCG levels [12,22,23,24] or even decreased fβ-hCG levels [15,25]. Two studies reported only an increase in fβ-hCG levels [10,26], and some studies reported no changes in maternal serum values in ART pregnancies [11,18,19].…”

Section: Discussionmentioning

confidence: 99%

“…In ART pregnancies maternal serum marker levels change during the first trimester affecting the risk assessment for DS [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. Counseling for prenatal screening of women carrying an ART pregnancy is complicated due to contradictory reports in FTS performance in ART pregnancies.…”

Section: Introductionmentioning

confidence: 99%

“…Counseling for prenatal screening of women carrying an ART pregnancy is complicated due to contradictory reports in FTS performance in ART pregnancies. Several studies reported higher false-positive rate (FPR) compared to spontaneously conceived pregnancies [5,6,7,8,9,10,11], some studies found higher FPR even after correction for maternal age [12,13,14,15] and others reported similar FPR [16,17,18,19,20]. Whether the prevalence of fetal chromosomal abnormalities in ART pregnancies is different from naturally conceived pregnancies is however unclear.…”

Section: Introductionmentioning

confidence: 99%

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Validation of Correction Factors for Serum Markers for First-Trimester Down Syndrome Screening in Singleton Pregnancies Conceived with Assisted Reproduction

Engels¹,

Pajkrt

Groot³

et al. 2013

Fetal Diagn Ther

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Objective: To validate previously computed correction factors for free β-human chorionic gonadotrophin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies with hormone treatment and to determine the effect on false-positive rate (FPR). Methods: Retrospective study on 249 IVF and 250 ICSI cases and 20,190 controls. Correction factors 1.42 (PAPP-A), 1.17 (fβ-hCG) in IVF; 1.56 (PAPP-A) in ICSI were applied on the absolute serum concentrations. Analysis was done on log₁₀-transformed multiples of medians (MoMs). Results: In the controls, mean PAPP-A and fβ-hCG MoM were 1.004 and 1.062. Before correction, mean PAPP-A MoM was significantly lower in IVF (0.757; p < 0.001) and in ICSI (0.671; p < 0.001) and after correction comparable (1.071; p = 0.053 in IVF; 1.048; p = 0.178 in ICSI). Before correction, mean fβ-hCG MoM was comparable (1.054; p = 0.59 in IVF and 1.051; p = 0.56 in ICSI) and after correction significantly higher in IVF (1.241; p < 0.001). After correction the likelihood for receiving a false-positive result was 1.03 in IVF pregnancies (95% CI 0.98-1.09; p = 0.248) and 1.02 in ICSI pregnancies (95% CI 0.97-1.07; p = 0.448). Conclusions: After correction the FPR in IVF and ICSI pregnancies with hormone treatment reduces to the observed FPR in the controls.

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First‐trimester screening markers are altered in pregnancies conceived after IVF/ICSI

Abstract: Objectives

Cited by 74 publications

References 53 publications

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

In combined first-trimester Down syndrome screening, the false-positive rate is not higher in pregnancies conceived after assisted reproduction compared with spontaneous pregnancies

How Effective Is First-Trimester Screening for Trisomy 21 Based on Ultrasound Only?

Validation of Correction Factors for Serum Markers for First-Trimester Down Syndrome Screening in Singleton Pregnancies Conceived with Assisted Reproduction

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