First report of a novel goose astrovirus outbreak in Muscovy ducklings in China

Chen, Qinxi; Yu, Zhengli; Xu, Xin; Ji, Jun; Yao, Lunguang; Kan, Yunchao; Bi, Yanlan; Xie, Qingmei

doi:10.1016/j.psj.2021.101407

Cited by 23 publications

(17 citation statements)

References 23 publications

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“…Additionally, previous studies have demonstrated that genetic diversity allows AAstVs to infect a wide range of avian species deserves further attention, as do reports that AAstVs such as ANV, CAstV and TAstV‐1 can cause infection in other avian species (Johnson et al., 2017). GAstVs have also been detected in Peking ducklings, cherry valley ducklings, Muscovy ducklings and chickens with swollen kidneys and visceral gout symptoms, which suggests potential cross‐species transmission of novel GAstVs in avians (Chen et al., 2020a; Chen et al., 2021; Li et al., 2021; Wei et al., 2020b). One distinct feature identified in duck‐derived GAstVs is that 50 aa in the ORF1a N‐terminal domain has been lost, resulting in a truncated protein relative to the original protein (data not shown here).…”

Section: Discussionmentioning

confidence: 99%

Genomic and epidemiological characteristics provide insights into the phylogeographic spread of goose astrovirus in China

Wang

Zhu

et al. 2022

Transbounding Emerging Dis

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Goose astrovirus (GAstV) is an emerging pathogen with a wide distribution in China that causes visceral gout and leads to significant economic losses in the goose industry. Here, 10 GAstV strains were isolated from different farms in southeast China. We performed an integrated analysis of the full‐genome sequences of these new strains alongside comprehensive epidemiological surveillance information from the database. Interestingly, the results showed two distinct genotypes of GAstV, which were evolutionarily distant from each other. Group I GAstVs were closely related to DAstV IV, and group II strains were classified with duck astrovirus (DAstV) II and turkey astrovirus (TAstV) II. Further investigation showed that among the GAstV I strains, ZJC14 and AHDY differed from FLX. Comparative analysis of 58 available genomes clustered the GAstV II strains into two subgroups. We identified two major mutation sites, 456 (E/D) and 540 (L/Q), in the capsid protein, which were related to distinct subgroups according to evolution. GAstV II subgroup 1a strains are the predominant strains in the current prevalent epidemiology. Phylogeographic analysis based on 90 reported cases from 13 provinces revealed the complexity and severity of GAstV epidemics in China, within which Henan, Anhui and Jiangsu provinces have suffered great impacts. According to these phylogeographic investigations, following the initial introduction of GAstV from Hunan Province, the dispersal of GAstV with different subgenotypes on a nationwide scale may be explained by the live gosling trade. Our findings have important implications for the evolution and dispersal of GAstV and will contribute to understanding the potential risk of GAstV.

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Section: Discussionmentioning

confidence: 99%

Genomic and epidemiological characteristics provide insights into the phylogeographic spread of goose astrovirus in China

Wang

Zhu

et al. 2022

Transbounding Emerging Dis

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“…A highly acute disease characterized by visceral gout was reported in a Muscovy duck farm in Henan Province. After isolation and identification, the virus causing gout symptoms in Muscovy ducklings was revealed to be GAstV (HNNY0620 strain) [ 50 ]. Similar diseases have been described in commercial duck farms (SDTA strain) [ 51 ] and Cherry Valley ducklings (SDXT strain) [ 36 ] in Shandong Province, China.…”

Section: Gastv Transmission Route and Hostmentioning

confidence: 99%

A Review of Emerging Goose Astrovirus Causing Gout

Liu

Sun

Liao

2022

BioMed Research International

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In recent years, an infection in geese caused by goose astrovirus (GAstV) has repeatedly occurred in coastal areas of China and rapidly spread to inland provinces. The infection is characterized by joint and visceral gout and is fatal. The disease has caused huge economic losses to China’s goose industry. GAstV is a nonenveloped, single-stranded, positive-sense RNA virus. As it is a novel virus, there is no specific classification. Here, we review the current understanding of GAstV. The virus structure, isolation, diagnosis and detection, innate immune regulation, and transmission route are discussed. In addition, since GAstV can cause gout in goslings, the possible role of GAstV in gout formation and uric acid metabolism is discussed. We hope that this review will inform researchers to rapidly develop effective methods to prevent and treat this disease.

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“…Uric acid disposition on the surface of the liver, kidney, heart and in the ureter and articular cavity were also observed in dead goslings [ 14 , 51 , 52 ]. Moreover, in 2020, Muscovy ducklings infected with GoAstV presented visceral gout with a mortality rate of up to 61% [ 53 ]. GoAstV-1 and GoAstV-2 viruses have been verified to be the causative agent of goose gout [ 10 , 27 , 29 , 54 , 55 ].…”

Section: Visceral Gout Caused By the Avian Astrovirusesmentioning

confidence: 99%

A Review of the Emerging Poultry Visceral Gout Disease Linked to Avian Astrovirus Infection

Sun

Zhang

et al. 2022

IJMS

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Avian astroviruses, including chicken astrovirus (CAstV), avian nephritisvirus (ANV), and goose astrovirus (GoAstV), are ubiquitous enteric RNA viruses associated with enteric disorders in avian species. Recent research has found that infection of these astroviruses usually cause visceral gout in chicken, duckling and gosling. However, the underlying mechanism remains unknown. In the current article, we review recent discoveries of genetic diversity and variation of these astroviruses, as well as pathogenesis after astrovirus infection. In addition, we discuss the relation between avian astrovirus infection and visceral gout in poultry. Our aim is to review recent discoveries about the prevention and control of the consequential visceral gout diseases in poultry, along with the attempt to reveal the possible producing process of visceral gout diseases in poultry.

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First report of a novel goose astrovirus outbreak in Muscovy ducklings in China

Cited by 23 publications

References 23 publications

Genomic and epidemiological characteristics provide insights into the phylogeographic spread of goose astrovirus in China

Genomic and epidemiological characteristics provide insights into the phylogeographic spread of goose astrovirus in China

A Review of Emerging Goose Astrovirus Causing Gout

A Review of the Emerging Poultry Visceral Gout Disease Linked to Avian Astrovirus Infection

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