2004
DOI: 10.1086/421776
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First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

Abstract: Ivermectin is increasingly being used to treat scabies, especially crusted (Norwegian) scabies. However, treatment failures, recrudescence, and reinfection can occur, even after multiple doses. Ivermectin resistance has been documented for some intestinal helminths in animals with intensive ivermectin exposure. Ivermectin resistance has also been induced in arthropods in laboratory experiments but, to date, has not been documented among arthropods in nature. We report clinical and in vitro evidence of ivermect… Show more

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Cited by 258 publications
(162 citation statements)
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“…Intensive use of ivermectin can lead to resistance, it has been documented for some intestinal helminthes (Soutello et al, 2007) . The resistance also noted against mites (Clark et al, 1995;Currie et al, 2004). From this point of view, it seems that ivermectin need synergistic product for rapid treatment of animals ecto-parasites.…”
Section: Introductionmentioning
confidence: 95%
“…Intensive use of ivermectin can lead to resistance, it has been documented for some intestinal helminthes (Soutello et al, 2007) . The resistance also noted against mites (Clark et al, 1995;Currie et al, 2004). From this point of view, it seems that ivermectin need synergistic product for rapid treatment of animals ecto-parasites.…”
Section: Introductionmentioning
confidence: 95%
“…It has been reported that Sarcoptes scabiei has developed at least partial resistance to IV, 19 and IV has previously been used for the mass treatment of onchocerciasis in Senegal. 20 In addition, some authors have suggested low effectiveness in children, who constituted the majority of our sample, because excretion of IV is reduced in subjects with a low physiological rate of sebum production.…”
Section: Introductionmentioning
confidence: 99%
“…These secondary infections cause significant sequelae (cellulitis, septicemia, and post-streptococcal glomerulonephritis), and the increased community streptococcal burden contributes to extreme levels of acute rheumatic fever and rheumatic heart disease (4). Recently, it has been reported that treatment efficacy for scabies is decreasing (5,6), indicating that the development of novel control strategies is necessary.…”
mentioning
confidence: 99%