volume 284, issue 49, P34413-34422 2009
DOI: 10.1074/jbc.m109.061911
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Simone A. Beckham, Sarah E. Boyd, Simone Reynolds, Charlene Willis, Masego Johnstone, Angela Mika, Pavla Simerská, Lakshmi C. Wijeyewickrema, A.Ian Smith, David J. Kemp, Robert N. Pike, Katja Fischer

Abstract: The scabies mite, Sarcoptes scabiei var. hominis, infests human skin, causing allergic reactions and facilitating bacterial infection by Streptococcus sp., with serious consequences such as rheumatic fever and rheumatic heart disease. To identify a possible drug target or vaccine candidate protein, we searched for homologues of the group 3 allergen of house dust mites, which we subsequently identified in a cDNA library. The native protein, designated Sar s 3, was shown to be present in the mite gut and excret…

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