First and second derivative spectrophotometric determination of cefoperazone and sulbactam in injections

Voltammetric studies on the antibiotic drug cefoperazone

“…The clear supernatant layer was filtrated through a 0.45 m milli-pore filter to produce a proteinfree human serum spiked with various concentrations of cefoperazone. (iv) Series of a Britton-Robinson (B-R) universal (pH [2][3][4][5][6][7][8][9][10][11] and an acetate (pH 3.6-5.5) buffers as supporting electrolytes were prepared.…”

“…These include spectrophotometry [2][3][4][5][6], spectrofluorimetry [7,8], colorimetry [9], capillary zone electrophoresis [10], high-performance liquid chromatography [11][12][13][14][15], and voltammetry [16][17][18].…”

Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC

“…The LLOQ for clavulanic acid in plasma was 1 g/ml and the precision (n = 6) at this concentration was 15.23%. The LLOQ for cefatrizine in plasma was 2 g/ml and the precision (n = 6) at this concentration was 18.22%, thus acceptable [28,29]. …”

“…The measured concentration of the proposed LLOQ should lie between 80 and 120% of its theoretical concentration and the R.S.D. should be less than 20% on a day-to-day basis [28,29]. LLOD and LLOQ were derived from multiple measurements in the low concentration range and were determined based on the signal-to-noise approach [30].…”

Quick bioanalytical method of quantification and validation of sulbactam in plasma using high performance liquid chromatography

“…Sulbactam analysis has been carried out in oral and injection pharmaceutical preparations using spectrophotometric, chemiluminescence, and fluorescent methods [8][9][10][11] and by capillary electrophoresis [12,13]. Many methods of analysis of sulbactam in biological fluids and pharmaceutical formulations using high performance liquid chromatography have been developed [15][16][17][18].…”